Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer

Autor: M. Rufaik Farook, Zack Croxford, Steffan Morgan, Anthony D. Horlock, Amy K. Holt, April Rees, Benjamin J. Jenkins, Carmen Tse, Emma Stanton, D. Mark Davies, Catherine A. Thornton, Nicholas Jones, I. Martin Sheldon, Emma E. Vincent, James G. Cronin

Publikováno v: Molecular Metabolism, Vol 81, Iss , Pp 101900- (2024)

The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients

Externí odkaz: https://doaj.org/article/3288d1dd7df84df79eb03d5700edacb0

Macrophage Plasticity in Reproduction and Environmental Influences on Their Function

Autor: Megan Chambers, April Rees, James G. Cronin, Manju Nair, Nicholas Jones, Catherine A. Thornton

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Macrophages are key components of the innate immune system and exhibit extensive plasticity and heterogeneity. They play a significant role in the non-pregnant cycling uterus and throughout gestation they contribute to various processes underpinning

Externí odkaz: https://doaj.org/article/e07fc9a780dc474e81eb9343a9d5d7a7

Maternal body mass index is associated with an altered immunological profile at 28 weeks of gestation

Autor: April Rees, Oliver Richards, Anastasia Allen-Kormylo, Nicholas Jones, Catherine A Thornton

Publikováno v: Clin Exp Immunol

Healthy pregnancy is accompanied by various immunological and metabolic adaptations. Maternal obesity has been implicated in adverse pregnancy outcomes such as miscarriage, preeclampsia, and gestational diabetes mellitus (GDM), while posing a risk to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f832b3fec6ad41f89d74348370084b06
https://doi.org/10.1093/cei/uxac023

Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

Autor: Emma E. Vincent, Diana Moreira, Caroline J. Bull, Julianna Blagih, Gareth W. Jones, Benjamin Jenkins, Nicholas Jones, Catherine A. Thornton, Karen H. Vousden, April Rees, David K. Finlay, Fabio Zani, David Hill, James G. Cronin, Daniele Avancini, Azari I. M. Bantan

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Jones, N, Hill, D G, Bull, C J, Jones, G, Vincent, E E, Thornton, C A & et al. 2021, ' Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation. ', Nature Communications, vol. 12, no. 1, 1209 (2021) . https://doi.org/10.1038/s41467-021-21461-4
Jones, N, Blagih, J, Zani, F, Rees, A, Hill, D G, Jenkins, B, Bull, C J, Moreira, D, Bantan, A, Cronin, J G, Avancini, D, Jones, G, Finlay, D K, Vousden, K, Vincent, E E & Thornton, C 2021, ' Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation ', Nature Communications, vol. 12, no. 1, 1209 (2021) . https://doi.org/10.1038/s41467-021-21461-4
Nature Communications

Fructose intake has increased substantially throughout the developed world and is associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our understanding of the metabolic and mechanistic implications for immune ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f8eaab8fcedce9276e8c1b655ebd5a
https://doaj.org/article/e704cf7cb7a0484a9ad0d96a44d08b6a

Canagliflozin Impairs T-Cell Effector Function via Metabolic Suppression in Autoimmunity

Autor: Benjamin J. Jenkins, Julianna Blagih, Simon Eastham, David Hill, Fernando M. Ponce-Garcia, Megan M. Hanlon, Eric Ma, Emma Bishop, Caroline J. Bull, April Rees, James G. Cronin, Elizabeth C. Jury, Sarah Dimeloe, Douglas J. Veale, Catherine A. Thornton, Karen H. Vousden, David Finlay, Ursula Fearon, Linda V. Sinclair, Gareth W. Jones, Emma E. Vincent, Nick Jones

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1a1a8e4bcdbf226e1df215106ef0e92
https://doi.org/10.2139/ssrn.4187261