Zobrazeno 1 - 7
of 7
pro vyhledávání: '"April P. Kelly"'
Autor:
Rosemary G. Clarke, Linda V. Sinclair, Maria Deak, April P. Kelly, Dario R. Alessi, David K. Finlay, Doreen A. Cantrell
Publikováno v:
The Journal of Immunology. 185:5973-5982
This study uses two independent genetic strategies to explore the requirement for phosphoinositide-dependent kinase-1 (PDK1) in the development of mature T cell populations from CD4/CD8 double-positive thymocytes. The data show that CD4/CD8 double-po
Publikováno v:
Febs Letters
Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases. Hence, in PD
Autor:
Doreen A. Cantrell, April P. Kelly, Rosie G Clarke, Freddy Radtke, David K. Finlay, Emma Fiorini, Heather J. Hinton
Publikováno v:
The EMBO Journal
EMBO Journal, vol. 26, no. 14, pp. 3441-50
EMBO Journal, vol. 26, no. 14, pp. 3441-50
Phosphoinositide-dependent kinase l (PDK1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Ribosomal S6 kinase (S6K) and p90Ribosomal S6 kinase (RSK). PDK1 is required for thymocyte differentiation and p
Publikováno v:
FEBS Letters. 580:2135-2140
In the present study, we have explored the impact of deleting a single allele of PDK1 in T cell progenitors on alpha/beta and gamma/delta T cell development. The data show that deleting a single allele of PDK1 allows differentiation of alpha/beta T c
Autor:
Edouard G. Stanley, Wei He, Ora Bernard, Joan Massagué, Mark Shannon, Victoria C. Foletta, Mei Ann Lim, April P. Kelly, Juliana Soosairajah, Supratik Das
Publikováno v:
The Journal of Cell Biology
Bone morphogenetic proteins (BMPs) regulate multiple cellular processes, including cell differentiation and migration. Their signals are transduced by the kinase receptors BMPR-I and BMPR-II, leading to Smad transcription factor activation via BMPR-I
Publikováno v:
Journal of Biological Chemistry. 276:32115-32121
PAK4 is the most recently identified member of the PAK family of serine/threonine kinases. PAK4 differs from other members of the PAK family in sequence and in many of its functions. Previously, we have shown that an important function of this kinase
Publikováno v:
The Journal of Immunology. 182:84.20-84.20
Phosphoinositide dependent kinase 1 (PDK1) is a serine/threonine kinase that phosphorylates and activates protein kinase B (PKB/Akt) and the p90 ribosomal S6 kinase (RSK). Naïve T-cells lacking PDK1 are viable in a thymic environment, show normal e