Zobrazeno 1 - 8
of 8
pro vyhledávání: '"April Nettesheim"'
Autor:
Angela Dixon, Myoung Sup Shim, April Nettesheim, Aislyn Coyne, Chien-Chia Su, Haiyan Gong, Paloma B. Liton
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
ABSTRACTGlaucoma encompasses a spectrum of disorders characterized by the chronic degeneration of retinal ganglion cell (RGC) axons and the progressive loss of RGCs, resulting in visual impairment. In this study, we investigated the effect of autopha
Externí odkaz:
https://doaj.org/article/868fae2bf19d49f1a28a82eb56a4edb1
Autor:
Angela Dixon, Myoung Sup Shim, April Nettesheim, Aislyn Coyne, Chien-Chia Su, Haiyan Gong, Paloma B. Liton
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-11 (2023)
Abstract Glaucoma is a group of diseases that leads to chronic degeneration of retinal ganglion cell (RGC) axons and progressive loss of RGCs, resulting in vision loss. While aging and elevated intraocular pressure (IOP) have been identified as the m
Externí odkaz:
https://doaj.org/article/1844fe9532ee42fba89bf6ef50cd893c
Autor:
Myoung Sup Shim, Angela Dixon, April Nettesheim, Kristin M. Perkumas, W. Daniel Stamer, Yang Sun, Paloma B. Liton
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
The Schlemm’s canal (SC) is a circular, lymphatic-like vessel located at the limbus of the eye that participates in the regulation of aqueous humor drainage to control intraocular pressure (IOP). Circumferential flow of aqueous humor within the SC
Externí odkaz:
https://doaj.org/article/cd2fe6229e094a40850af0a1bdc074d3
Publikováno v:
Autophagy
The trabecular meshwork (TM) is a key regulatory tissue of intraocular pressure (IOP) in the anterior chamber of eye. Dysfunction of the TM causes resistance to outflow of aqueous humor, which in turn leads to elevated IOP, a main risk factor of glau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af097255c3488f65f056a0987db86a1
https://doi.org/10.1080/15548627.2019.1662584
https://doi.org/10.1080/15548627.2019.1662584
Publikováno v:
Proc Natl Acad Sci U S A
Activation of autophagy is one of the responses elicited by high intraocular pressure (IOP) and mechanical stretch in trabecular meshwork (TM) cells. However, the mechanosensor and the molecular mechanisms by which autophagy is induced by mechanical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e3cc7e7b9d2d11ffa13271dfbe52be
https://europepmc.org/articles/PMC8020776/
https://europepmc.org/articles/PMC8020776/
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
The trabecular meshwork (TM) is a specialized ocular tissue, which is responsible, together with the Schlemm’s canal (SC), for maintaining appropriate levels of intraocular pressure. Dysfunction of these tissues leads to ocular hypertension and inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81a5ef255696fad487de24f5d1827b5
http://europepmc.org/articles/PMC6834604
http://europepmc.org/articles/PMC6834604
Autor:
Urmimala Raychaudhuri, Paloma B. Liton, Angela Dixon, April Nettesheim, Haiyan Gong, Myoung Sup Shim
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 78, p 78 (2021)
Journal of Clinical Medicine
Volume 10
Issue 1
Journal of Clinical Medicine
Volume 10
Issue 1
Extracellular matrix (ECM) deposition in the trabecular meshwork (TM) is one of the hallmarks of glaucoma, a group of human diseases and leading cause of permanent blindness. The molecular mechanisms underlying ECM deposition in the glaucomatous TM a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf25ef62dad3fcb7c5029ec32b59d82
https://doi.org/10.3390/jcm10010078
https://doi.org/10.3390/jcm10010078
Autor:
April Nettesheim, Myoung Sup Shim, Paloma B. Liton, Aislyn Coyne, Angela Dixon, Molly M. Walsh
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To investigate autophagy in the outflow pathway and ganglion cell layer in the aging and ocular hypertensive mouse. Methods Both 4-month-old and 18-month-old C57BL/6J and GFP-LC3 mice were subjected to unilateral injection of hypertonic salin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ec2b8046981b2014b38c796d379d73
https://doi.org/10.1167/iovs.61.10.31
https://doi.org/10.1167/iovs.61.10.31