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pro vyhledávání: '"April N. Le"'
Autor:
Sofia Bouhlal, April N. Le, Mehdi Farokhnia, Lorenzo Leggio, Erick Singley, Mikela B. Sheskier, Timmy Ton, Zhen Zhao, Mary R. Lee
Publikováno v:
Neuropharmacology. 137:230-239
Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the nervous system, plays an important role in biobehavioral processes that regulate alcohol seeking, food intake, and stress response. The metabotropic GABA-B receptor has been
Autor:
April N. Le, Lorenzo Leggio, Lisa A. Farinelli, Enoch Cobbina, Jenica D. Tapocik, Fatemeh Akhlaghi, Mwlod Ghareeb, Mehdi Farokhnia, Alexandra A. Dias, Markus Heilig, Mary R. Lee, Melanie L. Schwandt, Sofia Bouhlal
Publikováno v:
Molecular psychiatry
Rodent studies indicate that ghrelin receptor blockade reduces alcohol consumption. However, no ghrelin receptor blockers have been administered to heavy alcohol drinking individuals. Therefore, we evaluated the safety, tolerability, pharmacokinetic