Zobrazeno 1 - 10
of 22
pro vyhledávání: '"April Lo"'
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Alternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently caused by somatic splice site mutations or somatic mutations of splicing factor genes. However
Externí odkaz:
https://doaj.org/article/37b055328bd444adb4bdac801f188e35
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sen
Externí odkaz:
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
Autor:
Alexis M Thornton, Lishan Fang, April Lo, Maria McSharry, David Haan, Casey O'Brien, Alice H Berger, Marios Giannakis, Angela N Brooks
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009132 (2021)
While advancements in genome sequencing have identified millions of somatic mutations in cancer, their functional impact is poorly understood. We previously developed the expression-based variant impact phenotyping (eVIP) method to use gene expressio
Externí odkaz:
https://doaj.org/article/dd3122e631b94c459cfeb06f2dc62a6e
Autor:
Noushin Niknafs, Yi Zhong, John Alec Moral, Lance Zhang, Melody Xiaoshan Shao, April Lo, Alvin Makohon-Moore, Christine A. Iacobuzio-Donahue, Rachel Karchin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
In pancreatic cancer the Kras and Trp53 transgene driven KPC mouse model is used to experimentally study disease processes. Here, the authors analyse tumour evolution within the KPC model, finding both linear and branched evolution and highlighting t
Externí odkaz:
https://doaj.org/article/e07d8d5dc22044ab8c8f6ab2bcc5fd75
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Natasha Rekhtman, Athea Vichas, Robert K. Bradley, Jacqueline Watson, John K. Lee, Austin M. Gabel, Marina K. Baine, Amanda K. Riley, Shriya Kamlapurkar, Federica Piccioni, James D. Thomas, Iris Fung, Naomi T. Nkinsi, Emily M. Hatch, Jennifer Chen, Marc Ladanyi, Matthew G. Rees, Fujiko Duke, April Lo, Phoebe C. R. Parrish, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
CRISPR-based cancer dependency maps are accelerating advances in cancer precision medicine, but adequate functional maps are limited to the most common oncogenes. To identify opportunities for therapeutic intervention in other rarer subsets of cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13965f9f552d8b88b893eeabc031c85b
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
Autor:
Filip Mundt, Jacqueline Watson, Steven A. Carr, Sitapriya Moorthi, April Lo, Iris Fung, Shriya Kamlapurkar, Kristin D. Holmes, Alice H. Berger, Shaunt Fereshetian, Philipp Mertins
Publikováno v:
Sci Signal
Aberrant activation of the RAS family of guanosine triphosphatases (GTPases) is prevalent in lung adenocarcinoma, with somatic mutation of KRAS occurring in ~30% of tumors. We previously identified somatic mutations and amplifications of the gene enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93c167ee44cf3c4a0450d63a61a882f
https://doi.org/10.1126/scisignal.abc4520
https://doi.org/10.1126/scisignal.abc4520
Autor:
Oana Ursu, James T. Neal, Emily Shea, Pratiksha I. Thakore, Livnat Jerby-Arnon, Lan Nguyen, Danielle Dionne, Celeste Diaz, Julia Bauman, Mariam Mounir Mosaad, Christian Fagre, April Lo, Maria McSharry, Andrew O. Giacomelli, Seav Huong Ly, Orit Rozenblatt-Rosen, William C. Hahn, Andrew J. Aguirre, Alice H. Berger, Aviv Regev, Jesse S. Boehm
Publikováno v:
Nature Biotechnology. 40:1691-1691
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0406621b477fae1ad8d1cbdbf885db05
https://doi.org/10.1038/s41587-022-01495-9
https://doi.org/10.1038/s41587-022-01495-9
Autor:
John Alec Moral, Alvin Makohon-Moore, April Lo, Melody Xiaoshan Shao, Yi Zhong, Christine A. Iacobuzio-Donahue, Noushin Niknafs, Lance Zhang, Rachel Karchin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
The KPC mouse model, driven by the Kras and Trp53 transgenes, is well regarded for faithful recapitulation of human pancreatic cancer biology. However, the extent that this model recapitulates the subclonal evolution of this tumor type is unknown. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a20e39ebacafd1a7737f9f00a8cc947
http://link.springer.com/article/10.1038/s41467-019-13100-w
http://link.springer.com/article/10.1038/s41467-019-13100-w
Publikováno v:
Cancer Research. 82:778-778
Alternative mRNA splicing is dysregulated in many cancers including lung adenocarcinoma. These aberrant splicing events can sometimes be explained by mutations in splice sites or splicing factors. However, the majority of mis-splicing in cancers rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::414f4aee808c76fca3206f1bdc4fb366
https://doi.org/10.1158/1538-7445.am2022-778
https://doi.org/10.1158/1538-7445.am2022-778
Autor:
Sai Rithin Punjala, MD, April Logan, MS, Jing Han, MD, Ayato Obana, MD, Ashley J. Limkemann, MD, Austin D. Schenk, MD, William K. Washburn, MD
Publikováno v:
Transplantation Direct, Vol 10, Iss 6, p e1650 (2024)
Background. Variation in donation after circulatory death (DCD) organ recovery and liver transplant practices exist among transplant centers. This study aimed to evaluate these practices among centers in the United States. Methods. Scientific Registr
Externí odkaz:
https://doaj.org/article/e41b0258d2de4effa5ea70f3c290d697