Výsledky vyhledávání - "April L. Risinger"

Akademický článek

429 Eribulin Synergizes with STING Agonists by Enhancing Type 1 Interferon Expression and Improves Antitumor Efficacy as Combination Treatment

Autor: Leila Takahashi-Ruiz, Charles S. Fermaintt, Nancy Wilkinson, Peter Y. Chan, Susan L. Mooberry, April L. Risinger

Publikováno v: Journal of Clinical and Translational Science, Vol 7, Pp 128-128 (2023)

OBJECTIVES/GOALS: Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks effective targeted treatment options. TNBC's greater degree of immunogenicity than other breast tumors makes immunotherapy a viable strategy. Strategies t

Externí odkaz: https://doaj.org/article/b311f428910d47a6a3efcf9a48ce57be

Zobrazit plný text záznamu

Akademický článek

Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach

Autor: Lin Du, Samantha S. Yee, Karthik Ramachandran, April L. Risinger

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Taccalonolide microtubule stabilizers covalently bind β-tubulin and overcome taxane resistance mechanisms. Here, the authors synthesized fluorogenic taccalonolide probes and investigated the specificity of taccalonolide binding to β-tubulin and the

Externí odkaz: https://doaj.org/article/c2f5d7e5ec534b638cfd953643d55b03

Zobrazit plný text záznamu

Akademický článek

In Vivo Evaluation of (−)-Zampanolide Demonstrates Potent and Persistent Antitumor Efficacy When Targeted to the Tumor Site

Autor: Leila Takahashi-Ruiz, Joseph D. Morris, Phillip Crews, Tyler A. Johnson, April L. Risinger

Publikováno v: Molecules, Vol 27, Iss 13, p 4244 (2022)

Microtubule-stabilizing agents (MSAs) are a class of compounds used in the treatment of triple-negative breast cancer (TNBC), a subtype of breast cancer where chemotherapy remains the standard-of-care for patients. Taxanes like paclitaxel and docetax

Externí odkaz: https://doaj.org/article/57fba5c4dbac438ab33d49197c1958c1

Zobrazit plný text záznamu

Akademický článek

Efficacy of a Covalent Microtubule Stabilizer in Taxane-Resistant Ovarian Cancer Models

Autor: Samantha S. Yee, April L. Risinger

Publikováno v: Molecules, Vol 26, Iss 13, p 4077 (2021)

Ovarian cancer often has a poor clinical prognosis because of late detection, frequently after metastatic progression, as well as acquired resistance to taxane-based therapy. Herein, we evaluate a novel class of covalent microtubule stabilizers, the

Externí odkaz: https://doaj.org/article/c75dac68ba154c44bf29a60f6faca56c

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Didemnaketals F and G, New Bioactive Spiroketals from a Red Sea Ascidian Didemnum Species

Autor: Lamiaa A. Shaala, Diaa T.A. Youssef, Sabrin R.M. Ibrahim, Gamal A. Mohamed, Jihan M. Badr, April L. Risinger, Susan L. Mooberry

Publikováno v: Marine Drugs, Vol 12, Iss 9, Pp 5021-5034 (2014)

In continuation of our ongoing efforts to identify bioactive compounds from Red Sea marine organisms, a new collection of the ascidian Didemnum species was investigated. Chromatographic fractionation and HPLC purification of the CH2Cl2 fraction of an

Externí odkaz: https://doaj.org/article/f38ac2874b824911aabab01da209620d

Zobrazit plný text záznamu

Akademický článek

Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

Autor: Cristina C. Rohena, April L. Risinger, Ravi Kumar Vyas Devambatla, Nicholas F. Dybdal-Hargreaves, Roma Kaul, Shruti Choudhary, Aleem Gangjee, Susan L. Mooberry

Publikováno v: Molecules, Vol 21, Iss 12, p 1661 (2016)

While evaluating a large library of compounds designed to inhibit microtubule polymerization, we identified four compounds that have unique effects on microtubules. These compounds cause mixed effects reminiscent of both microtubule depolymerizers an

Externí odkaz: https://doaj.org/article/6703b455e5c74eb4bb7c78024318e1ec

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání