Zobrazeno 1 - 10
of 13
pro vyhledávání: '"April L. Lukowski"'
Autor:
Jianxin Liu, Jiayi Tian, Christopher Perry, April L. Lukowski, Tzanko I. Doukov, Alison R. H. Narayan, Jennifer Bridwell-Rabb
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
SxtT and GxtA are Rieske oxygenases that are involved in paralytic shellfish toxin biosynthesis and catalyze monohydroxylation reactions at different positions on the toxin scaffold. Here, the authors present crystal structures of SxtT and GxtA with
Externí odkaz:
https://doaj.org/article/773880ec53e14bf7b68655975633a375
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Rieske oxygenases are iron-dependent enzymes that catalyse C–H mono- and dihydroxylation reactions. Here, the authors characterise two cyanobacterial Rieske oxygenases, SxtT and GxtA that are involved in the biosynthesis of paralytic shellfish toxi
Externí odkaz:
https://doaj.org/article/b69e299e06b4475ab6229373dc78b546
Publikováno v:
J Nat Prod
The implementation of ortho-quinone methide (o-QM) intermediates in complex molecule assembly represents a remarkably efficient strategy designed by Nature and utilized by synthetic chemists. o-QMs have been taken advantage of in biomimetic syntheses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78b979e1de3ddb4ebd07beea5c83189
https://doi.org/10.1021/acs.jnatprod.1c01026
https://doi.org/10.1021/acs.jnatprod.1c01026
Autor:
Meagan E. Hinze, April L. Lukowski, Joshua B. Pyser, Markos Koutmos, Alison R. H. Narayan, Leena Mallik, Duncan C. Ellinwood, Brian M Carlson
Publikováno v:
ACS Chem Biol
Secondary metabolites are assembled by enzymes that often perform reactions with high selectivity and specificity. Many of these enzymes also tolerate variations in substrate structure, exhibiting promiscuity that enables various applications of a gi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd56be80f49a26e2361927b83d94650
https://doi.org/10.1021/acschembio.9b00964
https://doi.org/10.1021/acschembio.9b00964
Autor:
Lara E. Zetzsche, Jessica A. Yazarians, Suman Chakrabarty, Meagan E. Hinze, Lauren A. M. Murray, April L. Lukowski, Leo A. Joyce, Alison R. H. Narayan
Publikováno v:
Nature
Despite their varied purposes, many indispensable molecules in medicine, materials, and asymmetric catalysis share a biaryl core. The necessity of joining arene building blocks to access these valuable compounds has inspired multiple approaches for b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4209cb376a35410b11e60f2438696057
https://doi.org/10.33774/chemrxiv-2021-v0bv6-v2
https://doi.org/10.33774/chemrxiv-2021-v0bv6-v2
Autor:
Jianxin Liu, Jiayi Tian, Christopher Perry, April L. Lukowski, Tzanko I. Doukov, Alison R. H. Narayan, Jennifer Bridwell-Rabb
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Rieske oxygenases exploit the reactivity of iron to perform chemically challenging C–H bond functionalization reactions. Thus far, only a handful of Rieske oxygenases have been structurally characterized and remarkably little information exists reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17559689d124e8f32a4c89ca1f594fbd
https://pubmed.ncbi.nlm.nih.gov/35017498
https://pubmed.ncbi.nlm.nih.gov/35017498
Autor:
April L. Lukowski, Suman Chakrabarty, Jessica Yazarians, Lara Zetzsche, Alison R. H. Narayan, Meagan E. Hinze, Leo A. Joyce
Biocatalysis offers compelling advantages in synthesis, often becoming the method of choice based on sustainability, safety, and selectivity considerations. Despite these advantages, enzymes in synthesis are typically dedicated to functional group in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a30ecf1072e929b0b19d977efd9853b8
https://doi.org/10.33774/chemrxiv-2021-v0bv6
https://doi.org/10.33774/chemrxiv-2021-v0bv6
Publikováno v:
Chembiochem
Natural product biosynthetic pathways are composed of enzymes that use powerful chemistry to assemble complex molecules. Small molecule neurotoxins are examples of natural products with intricate scaffolds which often have high affinities for their b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9938ac4ca3210e226e6dd3dc1280855f
https://doi.org/10.1002/cbic.201800754
https://doi.org/10.1002/cbic.201800754
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Biocatalysts that perform C–H hydroxylation exhibit exceptional substrate specificity and site-selectivity, often through the use of high valent oxidants to activate these inert bonds. Rieske oxygenases are examples of enzymes with the ability to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ac0d2567ab7df5872a0504c075a9f6
https://doi.org/10.1038/s41467-020-16729-0
https://doi.org/10.1038/s41467-020-16729-0
Publikováno v:
Nature chemistry
Biocatalytic transformations employed by chemists are often restricted to simple functional group interconversions. In contrast, Nature has developed complexity-generating biocatalytic reactions within natural product pathways. These sophisticated ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfd5918b24c56be9593502c94f3cd90
https://doi.org/10.1038/nchem.2879
https://doi.org/10.1038/nchem.2879