First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody

Autor: Negar Omidvari, Terry Jones, Pat M Price, April L Ferre, Jacqueline Lu, Yasser G Abdelhafez, Fatma Sen, Stuart H Cohen, Kristin Schmiedehausen, Ramsey D Badawi, Barbara L Shacklett, Ian Wilson, Simon R Cherry

Publikováno v: medRxiv

With the majority of CD8+T cells residing and functioning in tissue, not blood, developing noninvasive methods forin vivoquantification of their biodistribution and kinetics in humans offers the means for studying their key role in adaptive immune re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53144233dbffb2ea0e913f42b477e6aa
https://doi.org/10.1101/2023.03.14.23287121

Cryopreservation of Human Mucosal Leukocytes.

Autor: Sean M Hughes, Zhiquan Shu, Claire N Levy, April L Ferre, Heather Hartig, Cifeng Fang, Gretchen Lentz, Michael Fialkow, Anna C Kirby, Kristina M Adams Waldorf, Ronald S Veazey, Anja Germann, Hagen von Briesen, M Juliana McElrath, Charlene S Dezzutti, Elizabeth Sinclair, Chris A R Baker, Barbara L Shacklett, Dayong Gao, Florian Hladik

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0156293 (2016)

BACKGROUND:Understanding how leukocytes in the cervicovaginal and colorectal mucosae respond to pathogens, and how medical interventions affect these responses, is important for developing better tools to prevent HIV and other sexually transmitted in

Externí odkaz: https://doaj.org/article/4562d3e4b3f14ff5b023327e2f0b32ee

HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.

Autor: Sergio Serrano-Villar, Talia Sainz, Sulggi A Lee, Peter W Hunt, Elizabeth Sinclair, Barbara L Shacklett, April L Ferre, Timothy L Hayes, Ma Somsouk, Priscilla Y Hsue, Mark L Van Natta, Curtis L Meinert, Michael M Lederman, Hiroyu Hatano, Vivek Jain, Yong Huang, Frederick M Hecht, Jeffrey N Martin, Joseph M McCune, Santiago Moreno, Steven G Deeks

Publikováno v: PLoS Pathogens, Vol 10, Iss 5, p e1004078 (2014)

A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) fails to normalize this ratio, even after they achieve normal

Externí odkaz: https://doaj.org/article/34190c80ee49467aaee778896123b3f0

Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.

Autor: Hiroyu Hatano, Steven A Yukl, April L Ferre, Erin H Graf, Ma Somsouk, Elizabeth Sinclair, Mohamed Abdel-Mohsen, Teri Liegler, Kara Harvill, Rebecca Hoh, Sarah Palmer, Peter Bacchetti, Peter W Hunt, Jeffrey N Martin, Joseph M McCune, Russell P Tracy, Michael P Busch, Una O'Doherty, Barbara L Shacklett, Joseph K Wong, Steven G Deeks

Publikováno v: PLoS Pathogens, Vol 9, Iss 10, p e1003691 (2013)

The study of HIV-infected "controllers" who are able to maintain low levels of plasma HIV RNA in the absence of antiretroviral therapy (ART) may provide insights for HIV cure and vaccine strategies. Despite maintaining very low levels of plasma virem

Externí odkaz: https://doaj.org/article/ae214c2d29d74180b2ebe7f3177f70c3

Cryopreservation of human mucosal tissues

Autor: Dayong Gao, April L. Ferre, Barbara L. Shacklett, Peter L. Anderson, Gretchen M. Lentz, Michael F. Fialkow, Anna C Kirby, Chris A. R. Baker, Charlene S. Dezzutti, Claire N. Levy, Elizabeth Sinclair, Florian Hladik, Fernanda Calienes, Rena D. Astronomo, Sean M. Hughes, Cory Shetler, M. Juliana McElrath, Lisa C. Rohan, Zhiquan Shu, Sarah E Yandura

Publikováno v: Hughes, SM; Ferre, AL; Yandura, SE; Shetler, C; Baker, CAR; Calienes, F; et al.(2018). Cryopreservation of human mucosal tissues. PLoS ONE, 13(7). doi: 10.1371/journal.pone.0200653. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/5hb228b7
PloS one, vol 13, iss 7
PLoS ONE, Vol 13, Iss 7, p e0200653 (2018)
PLoS ONE

© 2018 Hughes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21a93feae942f3d913f556df683b615
http://www.escholarship.org/uc/item/5hb228b7