Zobrazeno 1 - 10
of 34
pro vyhledávání: '"April L, Darling"'
Autor:
Marangelie Criado-Marrero, Danielle M. Blazier, Lauren A. Gould, Niat T. Gebru, Santiago Rodriguez Ospina, Debra S. Armendariz, April L. Darling, David Beaulieu-Abdelahad, Laura J. Blair
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Tau accumulation and progressive loss of neurons are associated with Alzheimer’s disease (AD). Aggregation of tau has been associated with endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR). While E
Externí odkaz:
https://doaj.org/article/64dff707852e4d75bac6a3dfb818855a
Autor:
Leslie A. Sandusky-Beltran, Andrii Kovalenko, Chao Ma, John Ivan T. Calahatian, Devon S. Placides, Mallory D. Watler, Jerry B. Hunt, April L. Darling, Jeremy D. Baker, Laura J. Blair, Mackenzie D. Martin, Sarah N. Fontaine, Chad A. Dickey, April L. Lussier, Edwin J. Weeber, Maj-Linda B. Selenica, Kevin R. Nash, Marcia N. Gordon, Dave Morgan, Daniel C. Lee
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-24 (2019)
Abstract Background Tau stabilizes microtubules; however, in Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. Our group recently uncovered a unique interaction between polyamine m
Externí odkaz:
https://doaj.org/article/f6fdfce93d6549e184299e4d7d512e9b
Autor:
Shannon E. Hill, David Beaulieu-Abdelahad, Andrea Lemus, Jack M. Webster, Santiago Rodriguez Ospina, April L. Darling, Mackenzie D. Martin, Shreya Patel, Liznair Bridenstine, Ronald Swonger, Steven Paul, Roy Blackburn, Laurent Calcul, Chad A. Dickey, James W. Leahy, Laura J. Blair
Publikováno v:
ACS Chemical Biology. 18:1124-1135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6129a08167a81c8a896513b79849deb0
https://doi.org/10.1021/acschembio.2c00919
https://doi.org/10.1021/acschembio.2c00919
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Misfolding, aggregation, and aberrant accumulation of proteins are central components in the progression of neurodegenerative disease. Cellular molecular chaperone systems modulate proteostasis, and, therefore, are primed to influence aberrant protei
Externí odkaz:
https://doaj.org/article/bfc987c1a76f4ac69bb8f196b12d8a14
Autor:
Iuliia A. Antifeeva, Hirofumi Arakawa, Graciela Lidia Boccaccio, Solomiia Boyko, Stefania Brocca, April L. Darling, Nathalie A. Djaja, Anna S. Fefilova, Ana Julia Fernández-Alvarez, Luisa A. Ferreira, Alexander V. Fonin, Laura R. Ganser, Jimena Giudice, Rita Grandori, Raza Haider, Helen Greenwood Hansma, Nikolay Ilyinsky, Pavel Ivanov, Brett Janis, Hao Jiang, Ashish Joshi, Irina M. Kuznetsova, David S. Libich, Sonia Longhi, Michael A. Menze, Yakov I. Mokin, Samrat Mukhopadhyay, Sua Myong, Niharika Nag, Semen Nesterov, Woei Shyuan Ng, Nobuo N. Noda, George L. Parra, Sunita Pathak, Swastik G. Pattanashetty, Giulia Pesce, Andrea Putnam, Claire L. Riggs, Santanu Sasidharan, Prakash Saudagar, Geraldine Seydoux, Hendrik Sielaff, Sergey A. Silonov, Evan Spruijt, Lucia C. Strader, Witold K. Surewicz, María Gabriela Thomas, P. Todd Stukenberg, Timir Tripathi, Konstantin K. Turoverov, Vladimir N. Uversky, Anuja Walimbe, Boris Y. Zaslavsky, Ziqing Winston Zhao
Publikováno v:
Droplets of Life ISBN: 9780128239674
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf67933525e86a2be8efc0768456a94
https://doi.org/10.1016/b978-0-12-823967-4.01002-2
https://doi.org/10.1016/b978-0-12-823967-4.01002-2
Autor:
April L. Darling, Vladimir N. Uversky
Publikováno v:
Droplets of Life ISBN: 9780128239674
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94dc302b20a824e92f7671b4d61c0654
https://doi.org/10.1016/b978-0-12-823967-4.00002-6
https://doi.org/10.1016/b978-0-12-823967-4.00002-6
Autor:
Jack M. Webster, April L. Darling, Taylor A. Sanders, Danielle M. Blazier, Yamile Vidal-Aguiar, David Beaulieu-Abdelahad, Drew G. Plemmons, Shannon E. Hill, Vladimir N. Uversky, Paula C. Bickford, Chad A. Dickey, Laura J. Blair
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5442 (2020)
Misfolding, aggregation and accumulation of proteins are toxic elements in the progression of a broad range of neurodegenerative diseases. Molecular chaperones enable a cellular defense by reducing or compartmentalizing these insults. Small heat shoc
Externí odkaz:
https://doaj.org/article/51184ddcd7b0414e803ab2c509eb21a3
Autor:
April L. Darling, Vladimir N. Uversky
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) are functional proteins and domains that devoid stable secondary and/or tertiary structure. IDPs/IDPRs are abundantly present in various proteomes, where th
Externí odkaz:
https://doaj.org/article/c1281725a1a2402bab4b7cda62921d32
Autor:
Chad A. Dickey, Stefan G Creodore, April L. Darling, Laura J. Blair, Vladimir N. Uversky, Jan Dahrendorff
Publikováno v:
Protein Sci
Alzheimer's disease is a progressive fatal neurodegenerative disease with no cure or effective treatments. The hallmarks of disease include extracellular plaques and intracellular tangles of aggregated protein. The intracellular tangles consist of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f700f12734401f8e4407c393ca1210
https://doi.org/10.1002/pro.4060
https://doi.org/10.1002/pro.4060
Publikováno v:
Polymers, Vol 11, Iss 6, p 990 (2019)
The visible outcome of liquid-liquid phase transitions (LLPTs) in cells is the formation and disintegration of various proteinaceous membrane-less organelles (PMLOs). Although LLPTs and related PMLOs have been observed in living cells for over 200 ye
Externí odkaz:
https://doaj.org/article/94083596587b417eb22f82e0a3510d28