Zobrazeno 1 - 10
of 15
pro vyhledávání: '"April Haller"'
Autor:
Belen Rivero-Gutierrez, April Haller, Jenna Holland, Emily Yates, Radha Khrisna, Kirk Habegger, Richard Dimarchi, David D'Alessio, Diego Perez-Tilve
Publikováno v:
Molecular Metabolism, Vol 17, Iss , Pp 28-38 (2018)
Objective: Mice with congenital loss of the glucagon receptor gene (Gcgr−/− mice) remain normoglycemic in insulinopenic conditions, suggesting that unopposed glucagon action is the driving force for hyperglycemia in Type-1 Diabetes Mellitus (T1DM
Externí odkaz:
https://doaj.org/article/ad4c8df431c547afbdea34e422f6c6ea
Autor:
Anja Jaeschke, April Haller, James G. Cash, Christopher Nam, Emily Igel, Anton J.M. Roebroek, David Y. Hui
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100012- (2021)
The impairment of LDL receptor-related protein-1 (LRP1) in numerous cell types is associated with obesity, diabetes, and fatty liver disease. Here, we compared the metabolic phenotype of C57BL/6J wild-type and LRP1 knock-in mice carrying an inactivat
Externí odkaz:
https://doaj.org/article/c679df6c5e8843a8acdf5da2571f9bd9
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Background and objective: Apolipoprotein E Receptor-2 (apoER2) is a type I transmembrane receptor in the LDL receptor family and is expressed in vascular smooth muscle cells (VSMC), endothelium, and macrophages. An apoER2 mutation referred to as ApoE
Autor:
Hui-Ping Lin, Bhupesh Singla, WonMo Ahn, Pushpankur Ghoshal, Maria Blahove, Mary Cherian-Shaw, Alex Chen, April Haller, David Y. Hui, Kunzhe Dong, Jiliang Zhou, Joseph White, Alexis M. Stranahan, Agnieszka Jasztal, Rudolf Lucas, Brian K. Stansfield, David Fulton, Stefan Chlopicki, Gábor Csányi
Accumulation of lipid-laden foam cells in the arterial wall plays a central role in atherosclerotic lesion development, plaque progression, and late-stage complications of atherosclerosis. However, there are still fundamental gaps in our knowledge of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0730db1d5205d1dc021afe04ea3a01a9
https://ruj.uj.edu.pl/xmlui/handle/item/304211
https://ruj.uj.edu.pl/xmlui/handle/item/304211
Autor:
Emily Igel, Patrick R. Wolfkiel, Anja Jaeschke, David Y. Hui, April Haller, Melissa A. Orr-Asman
Publikováno v:
The Journal of Biological Chemistry
Polymorphisms in the apolipoprotein E (apoE) gene are risk factors for chronic inflammatory diseases including atherosclerosis. The gene product apoE is synthesized in many cell types and has both lipid transport-dependent and lipid transport-indepen
Autor:
Karen J. Roelofs, Darleen A. Sandoval, Chelsea R. Hutch, Kyle Leix, Thomas Klein, April Haller, David D. D’Alessio, Robert Augustin, Randy J. Seeley, Joyce Sorrell
Publikováno v:
Diabetologia
AIMS/HYPOTHESIS: Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two peptides that function to promote insulin secretion. Dipeptidyl peptidase-4 (DPP-4) inhibitors increase the bioavailability of both GLP-1
Publikováno v:
BMC Medical Genetics
Background Autosomal dominant familial hypercholesterolemia (ADH; MIM#143890) is one of the most common monogenic disorders characterized by elevated circulatory LDL cholesterol. Initial studies in humans with ADH identified a potential relationship
Autor:
Jenna Holland, Belen Rivero-Gutierrez, Diego Perez-Tilve, Radha Khrisna, April Haller, David A. D'Alessio, Emily Yates, Richard D. DiMarchi, Kirk M. Habegger
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 17, Iss, Pp 28-38 (2018)
Molecular Metabolism, Vol 17, Iss, Pp 28-38 (2018)
Objective Mice with congenital loss of the glucagon receptor gene (Gcgr−/− mice) remain normoglycemic in insulinopenic conditions, suggesting that unopposed glucagon action is the driving force for hyperglycemia in Type-1 Diabetes Mellitus (T1DM)
Autor:
April Haller, Rohit Kohli, Adam P. Chambers, Denovan P. Begg, Randy J. Seeley, Kris A. Steinbrecher, Stephen C. Woods, Joram D. Mul, Mitchell B. Cohen
Publikováno v:
Diabetes
Uroguanylin is a gastrointestinal hormone primarily involved in fluid and electrolyte handling. It has recently been reported that prouroguanylin, secreted postprandially, is converted to uroguanylin in the brain and activates the receptor guanylate
Autor:
Joyce Sorrell, Patrick Tso, April Haller, Darleen A. Sandoval, Josh W. Pressler, Randy J. Seeley, Fei Wang
Publikováno v:
Diabetes
Bariatric surgery is the most successful strategy for treating obesity, yet the mechanisms for this success are not clearly understood. Clinical literature suggests that plasma levels of apolipoprotein A-IV (apoA-IV) rise with Roux-en-Y gastric bypas