Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Appswe ps1de9"'
Publikováno v:
Journal of Alzheimer's disease 81(3), 855-869 (2021). doi:10.3233/JAD-201540
Transgenic mouse models serve a better understanding of Alzheimer’s disease (AD) pathogenesis and its consequences on neuronal function. Well-known and broadly used AD models are APPswe/PS1dE9 mice, which are able to reproduce features of amyloid-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0dd3887f529c43011add2eb332d29c
https://doi.org/10.3233/jad-201540
https://doi.org/10.3233/jad-201540
Background Accumulating evidence has indicated that inflammatory damage plays a vital role in the pathogenesis of Alzheimer’s disease (AD) and represents one of the therapeutic targets. Z-Guggulsterone (Z-GS) is an active component extracted from m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c51a8fe25b9161587160e304326eaba6
https://doi.org/10.21203/rs.3.rs-763008/v1
https://doi.org/10.21203/rs.3.rs-763008/v1
Autor:
Smitha Karunakaran
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience
Frontiers in Neuroscience
Mild behavioral deficits, which are part of normal aging, can be early indicators of an impending Alzheimer's disease. Using the APPswe/PS1dE9 (APP/PS1) mouse model of Alzheimer's disease, we utilized the Morris water maze spatial learning paradigm t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3d9b62d538593d5648260c0cf31ccc
https://pubmed.ncbi.nlm.nih.gov/33384577
https://pubmed.ncbi.nlm.nih.gov/33384577
Autor:
Yingkun He, Jing Shi, Yingxue Rao, Huili Feng, Peng Wei, Jinzhou Tian, Pengwen Wang, Fang Chen
Publikováno v:
Journal of Traditional Chinese Medical Sciences, Vol 7, Iss 3, Pp 333-334 (2020)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da7fb47d0ace25c2ca7261928a9f780
http://www.sciencedirect.com/science/article/pii/S2095754820300867
http://www.sciencedirect.com/science/article/pii/S2095754820300867
Publikováno v:
Behavioural Neurology, Vol 2020 (2020)
Behavioural Neurology
Behavioural Neurology
Objectives. Retina abnormalities are related to cognitive disorders in patients with Alzheimer’s disease (AD). Retinal amyloid beta (Aβ) can be labeled by curcumin. We measured Aβ content in the cerebrum and retina of APPswe/PS1dE9 (APP) transgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f947288cf7d44623dc68c7cf626fe1
https://doaj.org/article/603789472b0b4497960eb08d2cd6726a
https://doaj.org/article/603789472b0b4497960eb08d2cd6726a
Autor:
Sonia Abad, Antoni Camins, David Pubill, Carla Ramon-Duaso, Raúl López-Arnau, Jaume Folch, Elena Escubedo, Jordi Camarasa
Publikováno v:
Journal of psychopharmacology (Oxford, England). 33(9)
Background: 3,4-Methylenedioxymethamphetamine (MDMA) is still one of the most consumed drugs by adolescents. Its abuse is related with cognitive impairment, which seems due to maladaptive plasticity and neural stress. In turn, new hypotheses suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd861021324a80bba2caff0e31661ec8
https://pubmed.ncbi.nlm.nih.gov/31219369
https://pubmed.ncbi.nlm.nih.gov/31219369
Publikováno v:
Behavioural Brain Research. 313:71-81
Performance was examined on three variants of the spontaneous object recognition (SOR) task, in 5-month old APPswe/PS1dE9 mice and wild-type littermate controls. A deficit was observed in an object-in-place (OIP) task, in which mice are preexposed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c2828f23d28894a1ec7380cc48bd66
https://doi.org/10.1016/j.bbr.2016.07.008
https://doi.org/10.1016/j.bbr.2016.07.008
Autor:
Bart P. F. Rutten, Annerieke S.R. Sierksma, Fred W. van Leeuwen, Laurence de Nijs, Jos Prickaerts, Govert Hoogland, Tim Vanmierlo, Harry W.M. Steinbusch, Daniel L.A. van den Hove
Publikováno v:
Journal of Alzheimer's Disease, 51(3), 677-682. IOS Press
Treatment of Alzheimer's disease (AD) patients with the antidepressant fluoxetine is known to improve memory and cognitive function. However, the mechanisms underlying these effects are largely unknown. To unravel these mechanisms, we aimed to treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6171b831a3b9d29bbf2858ba9e9acc96
https://doi.org/10.3233/jad-151066
https://doi.org/10.3233/jad-151066
Autor:
Xuerong Sun, Shicheng Li, Yaxin Sun, Xiaoshuang Zhang, Ping Zhong, Jingyu Xiong, Zhizhang Dong
Publikováno v:
Biology of Sport, Vol 32, Iss 4, Pp 295-300 (2015)
Biology of Sport
Biology of Sport
Increasing evidence suggests that physical activity could delay or attenuate the symptoms of Alzheimer's disease (AD). But the underlying mechanisms are still not fully understood. To investigate the effect of long-term treadmill exercise on the spat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0770ae587daa98543e56d9a32e878415
http://www.termedia.pl/Long-term-treadmill-exercise-improves-spatial-memory-of-male-appswe-ps1de9-mice-by-regulation-of-BDNF-expression-and-microglia-activation,78,26183,1,1.html
http://www.termedia.pl/Long-term-treadmill-exercise-improves-spatial-memory-of-male-appswe-ps1de9-mice-by-regulation-of-BDNF-expression-and-microglia-activation,78,26183,1,1.html
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