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Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology.

Autor: Ramesh S; Department of Medicine, University of Chicago, Chicago, IL, USA., Dyer E; Department of Medicine, University of Chicago, Chicago, IL, USA., Pomaville M; Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Doytcheva K; Anatomic Pathology Department of Oklahoma University Medical Center, Oklahoma City, OK, USA., Dolezal J; Geisinger Cancer Institute, Danville, PA, USA., Kochanny S; Department of Medicine, University of Chicago, Chicago, IL, USA., Terhaar R; Pritzker School of Medicine, University of Chicago, Chicago, IL, USA., Mehrhoff CJ; Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA., Patel K; Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, WA, USA.; Division of Hematology/Oncology and Bone Marrow Transplant, Department of Pediatrics, University of Washington, Seattle, WA, USA., Brewer J; Applied Data Science Program, University of Chicago, Chicago, IL, USA., Kusswurm B; Applied Data Science Program, University of Chicago, Chicago, IL, USA., Naranjo A; Children's Oncology Group Statistics and Data Center, Department of Biostatistics, University of Florida, Gainesville, FL, USA., Shimada H; Department of Pathology and Pediatrics, Stanford University, Stanford, CA, USA., Cipriani NA; Department of Pathology, University of Chicago, Chicago, IL, USA., Husain AN; Department of Pathology, University of Chicago, Chicago, IL, USA., Pytel P; Department of Pathology, University of Chicago, Chicago, IL, USA., Sokol EA; Division of Hematology, Oncology, and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Cohn SL; Department of Pediatrics, University of Chicago, Chicago, IL, USA., George RE; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Pearson AT; Department of Medicine, University of Chicago, Chicago, IL, USA., Applebaum MA; Department of Pediatrics, University of Chicago, Chicago, IL, USA. mapplebaum@bsd.uchicago.edu.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2024 Nov 08; Vol. 8 (1), pp. 255. Date of Electronic Publication: 2024 Nov 08.

Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation.

Autor: Pomaville M; Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA., Chennakesavalu M; Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA., Wang P; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA., Jiang Z; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA., Sun HL; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA., Ren P; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA., Borchert R; Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA., Gupta V; Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA., Ye C; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA., Ge R; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA., Zhu Z; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA., Brodnik M; Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA., Zhong Y; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA., Moore K; Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA., Salwen H; Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA., George RE; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Krajewska M; School of Biochemistry and Cell Biology, Biosciences Institute, University College Cork, Cork, Ireland., Chlenski A; Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA., Applebaum MA; Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA., He C; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, University of Chicago, Chicago, Il 60637 USA., Cohn SL; Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA. Electronic address: scohn@bsd.uchicago.edu.

Publikováno v: Cell reports [Cell Rep] 2024 May 28; Vol. 43 (5), pp. 114165. Date of Electronic Publication: 2024 Apr 30.

5-Hydroxymethylcytosine Profiling of Cell-Free DNA Identifies Bivalent Genes That Are Prognostic of Survival in High-Risk Neuroblastoma.

Autor: Chennakesavalu M; Department of Pediatrics, University of Chicago, Chicago, IL., Moore K; Department of Pediatrics, University of Chicago, Chicago, IL., Chaves G; Department of Pediatrics, University of Chicago, Chicago, IL., Veeravalli S; Department of Pediatrics, University of Chicago, Chicago, IL., TerHaar R; Department of Pediatrics, University of Chicago, Chicago, IL., Wu T; Department of Chemistry, University of Chicago, Chicago, IL., Lyu R; Department of Chemistry, University of Chicago, Chicago, IL., Chlenski A; Department of Pediatrics, University of Chicago, Chicago, IL., He C; Department of Chemistry, University of Chicago, Chicago, IL.; Howard Hughes Medical Institute, University of Chicago, Chicago, IL., Piunti A; Department of Pediatrics, University of Chicago, Chicago, IL., Applebaum MA; Department of Pediatrics, University of Chicago, Chicago, IL.

Publikováno v: JCO precision oncology [JCO Precis Oncol] 2024 Jan; Vol. 8, pp. e2300297.

Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma.

Autor: Vayani OR; Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, USA., Kaufman ME; Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, USA., Moore K; Department of Pediatrics, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois, USA., Chennakesavalu M; Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, USA., TerHaar R; Department of Pediatrics, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois, USA., Chaves G; Department of Pediatrics, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois, USA., Chlenski A; Department of Pediatrics, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois, USA., He C; Department of Chemistry, The University of Chicago, Chicago, Illinois, USA., Cohn SL; Department of Pediatrics, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois, USA., Applebaum MA; Department of Pediatrics, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois, USA.

Publikováno v: Pediatric blood & cancer [Pediatr Blood Cancer] 2024 Jan; Vol. 71 (1), pp. e30735. Date of Electronic Publication: 2023 Oct 20.