Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Apple Long"'
Autor:
Mitsuteru Natsuizaka, Kelly A. Whelan, Shingo Kagawa, Koji Tanaka, Veronique Giroux, Prasanna M. Chandramouleeswaran, Apple Long, Varun Sahu, Douglas S. Darling, Jianwen Que, Yizeng Yang, Jonathan P. Katz, E. Paul Wileyto, Devraj Basu, Yoshiaki Kita, Shoji Natsugoe, Seiji Naganuma, Andres J. Klein-Szanto, J. Alan Diehl, Adam J. Bass, Kwok-Kin Wong, Anil K. Rustgi, Hiroshi Nakagawa
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Notch receptors can exert different roles in cancer. In this manuscript, the authors reveal that Notch1 activation and EMT promote tumor initiation and cancer cell heterogeneity in squamous cell carcinoma, while the repression of Notch3 by ZEB1 limit
Externí odkaz:
https://doaj.org/article/6f8691ad6d324ab0a967f60181be89c5
Autor:
Apple Long, Melissa Magrath, Meredith Mihalopoulos, Jody A. Rule, Deepak Agrawal, Robert Haley, Kurt Kleinschmidt, William M. Lee
Publikováno v:
The American journal of gastroenterology. 117(8)
Acetaminophen (APAP) toxicity is the main cause of acute liver failure in the United States. A prior series (1992-1995) identified 71 hospitalized adults with APAP toxicity through the International Statistical Classification of Disease and Related H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50eef2b4ef303e5adbf035ecba7ce6f4
https://pubmed.ncbi.nlm.nih.gov/35926495
https://pubmed.ncbi.nlm.nih.gov/35926495
Autor:
Monal Shah, Fred P. Cerise, Kristin S. Alvarez, Apple Long, Christopher J. Madden, Jillian Smartt, Kavita Bhavan, Trish M. Perl, Sheryl Mathew
Publikováno v:
Health Equity
Purpose: Influenza/pneumonia is the eighth leading cause of death in the United States. The 2020-2021 influenza season is predicted to be further impacted by COVID-19 infections. Historical data reflect disproportionate morbidity and mortality rates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b863c9491535809cc37f115efc3af4
https://pubmed.ncbi.nlm.nih.gov/34084986
https://pubmed.ncbi.nlm.nih.gov/34084986
Publikováno v:
Current Colorectal Cancer Reports. 13:341-351
Colorectal cancer (CRC) is the fourth most common cancer in both men and women in the United States, resulting in over 55,000 deaths annually. Environmental and genetic factors influence the development of CRC, and inflammation is a critical hallmark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e76780090d0d1e319884c369089fb93
https://doi.org/10.1007/s11888-017-0373-6
https://doi.org/10.1007/s11888-017-0373-6
Autor:
Ashley A. Lento, Hiroshi Nakagawa, Kensuke Suzuki, Qiaosi Tang, Mirazul Islam, Adam J. Bass, Anil K. Rustgi, Veronique Giroux, Gizem Efe, Apple Long, E. Paul Wileyto, Tatiana A. Karakasheva, Andres J. Klein-Szanto
Publikováno v:
EMBO Rep
Esophageal squamous cell carcinoma (ESCC) is the most common subtype of esophageal cancer worldwide. The most commonly mutated gene in ESCC is TP53. Using a combinatorial genetic and carcinogenic approach, we generate a novel mouse model of ESCC expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e513b1d2f53077ca2455b53464a03094
https://pubmed.ncbi.nlm.nih.gov/33403789
https://pubmed.ncbi.nlm.nih.gov/33403789
Publikováno v:
Oncogene
Retrograde signaling is a mechanism by which mitochondrial dysfunction is communicated to the nucleus for inducing a metabolic shift essential for cell survival. Previously, we showed that partial mitochondrial DNA (mtDNA) depletion in different cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf902f70cb9fef312c90209d52fd07ad
http://europepmc.org/articles/PMC5192009
http://europepmc.org/articles/PMC5192009
Autor:
Kathryn E. Hamilton, Koji Tanaka, Veronique Giroux, Hiroshi Nakagawa, Marie Pier Tetreault, Ju Seog Lee, Apple Long, Andres J. Klein-Szanto, Anil K. Rustgi, Kelly A. Whelan
Publikováno v:
Carcinogenesis. 36:598-606
Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53 mutation can invade into the extracellular matrix when grown in 3D-organotypic cultures (OTC) and mimic early invasion in esophageal squamous cell carcinoma (ESCC). We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9985f4cb9bb4316f2af942aa6a38303
https://doi.org/10.1093/carcin/bgv025
https://doi.org/10.1093/carcin/bgv025
Autor:
Hideaki Kinugasa, Apple Long, Kazuhide Yamamoto, Shingo Kagawa, Sanders Chang, Satish Srinivasan, J A Diehl, Narayan G. Avadhani, D.K. St. Clair, Koji Tanaka, Mitsuteru Natsuizaka, Manti Guha, Hiroshi Nakagawa, Kelly A. Whelan, Andy Guo
Publikováno v:
Oncogene
Epithelial-mesenchymal transition (EMT) promotes cancer cell invasion, metastasis and treatment failure. EMT may be activated in cancer cells by reactive oxygen species (ROS). EMT may promote conversion of a subset of cancer cells from a CD44(low)-CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208e8e0c8af8ded87638b621f692c214
https://doi.org/10.1038/onc.2014.449
https://doi.org/10.1038/onc.2014.449
Autor:
Veronique Giroux, Morgan Sammons, Ashley A. Lento, Andres J. Klein-Szanto, Anil K. Rustgi, Apple Long, Qiaosi Tang, Shelly Berger
Publikováno v:
Cancer Research. 77:2578-2578
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer characterized by a high rate of metastasis, limited therapeutic options, and a poor prognosis. However, there is limited information regarding the molecular mechanisms underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::650e02d206b3f99fb09459e2245a6e0b
https://doi.org/10.1158/1538-7445.am2017-2578
https://doi.org/10.1158/1538-7445.am2017-2578
Autor:
Shelley L. Berger, Jiajun Zhu, Anil K. Rustgi, Sponsor: Irving Nachamkin, Apple Long, Veronique Giroux
Publikováno v:
American Journal of Clinical Pathology. 143:A050-A050
Wild-type TP53 , a potent tumor suppressor gene, is responsible for initiating appropriate responses to a variety of cellular stresses and is the most commonly mutated gene in human cancers. Strikingly, most TP53 mutations are missense mutations with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21ce4e0a107d4aa5533173eaf360b94d
https://doi.org/10.1093/ajcp/143.suppl1.051
https://doi.org/10.1093/ajcp/143.suppl1.051