Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Appl1"'
Autor:
Chunyu Zhao, Jianing Li
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract Background Hypoxia/reoxygenation (H/R) induces cardiomyocyte ferroptosis, a core remodeling event in myocardial ischemia/reperfusion injury. Methyltransferase-like 14 (METTL14) emerges as a writer of N6-methyladenosine (m6A) modification. Th
Externí odkaz:
https://doaj.org/article/c414905c708c4a10bce1a68dcd8586e5
Autor:
Haigang Cao, Tianning Du, Chenchen Li, Lingling Wu, Jieming Liu, Yuan Guo, Xiao Li, Gongshe Yang, Jianjun Jin, Xin’e Shi
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Skeletal muscle is the largest tissue in the body, and it affects motion, metabolism and homeostasis. Skeletal muscle development comprises myoblast proliferation, fusion and differentiation to form myotubes, which subsequently fo
Externí odkaz:
https://doaj.org/article/24fd31c1240f480e8fe10b0a42a6e6e2
Autor:
Sandip Mukherjee, Molee Chakraborty, Eliwaza N. Msengi, Jake Haubner, Jinsong Zhang, Matthew J. Jellinek, Haley L. Carlson, Kelly Pyles, Barbara Ulmasov, Andrew J. Lutkewitte, Danielle Carpenter, Kyle S. McCommis, David A. Ford, Brian N. Finck, Brent A. Neuschwander-Tetri, Anutosh Chakraborty
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101767- (2023)
Objective: Defining the regulators of cell metabolism and signaling is essential to design new therapeutic strategies in obesity and NAFLD/NASH. E3 ubiquitin ligases control diverse cellular functions by ubiquitination-mediated regulation of protein
Externí odkaz:
https://doaj.org/article/b2642d46704a4c24822cb884661aab61
Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Megalin/LRP2 is the primary multiligand receptor for the re-absorption of low molecular weight proteins in the proximal renal tubule. Its function is significantly dependent on its endosomal trafficking. Megalin recycling from endosomal compartments
Externí odkaz:
https://doaj.org/article/045af641660a4c55bdc466d912f883c3
Publikováno v:
The Ukrainian Biochemical Journal, Vol 92, Iss 5, Pp 33-40 (2020)
Diabetes is a chronic disease and a public health problem globally. L-Carnitine is synthesized in the liver, promotes fatty acids oxidation and currently is used as a supplement against weight gain. Carnitine level is found to be reduced in diabetic
Externí odkaz:
https://doaj.org/article/69a8f22fee3f4c3589c1db058d0cf88e
Akademický článek
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Autor:
Silvia Sposini, Francesco De Pascali, Rachel Richardson, Niamh S. Sayers, David Perrais, Henry N. Yu, Stephen Palmer, Selva Nataraja, Eric Reiter, Aylin C. Hanyaloglu
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor (GPCR) with pivotal roles in reproduction. One key mechanism dictating the signal activity of GPCRs is membrane trafficking. After binding its hormone FSH, FSHR undergoes in
Externí odkaz:
https://doaj.org/article/e23f5dba43fd4c0eb3ef91dc52330195
Akademický článek
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Publikováno v:
The Ukrainian Biochemical Journal, Vol 89, Iss 6, Pp 48-55 (2017)
Diabetes is considered as a metabolic disease in which insulin secretion and functions are disturbed and characterized by hyperglycemia. L-carnitine is synthesized in most mammals and plays critical role in fatty acid oxidation and energy production.
Externí odkaz:
https://doaj.org/article/34637b19378243dfab96c87ea65e4fb6