A Phase II trial of Higher RadiOtherapy Dose In The Eradication of early rectal cancer (APHRODITE): protocol for a multicentre, open-label randomised controlled trial

Autor: Hudson, EM, Noutch, S, Brown, S, Adapala, R, Bach, SP, Burnett, C, Burrage, A, Gilbert, A, Hawkins, M, Howard, D, Jefford, M, Kochhar, R, Saunders, M, Seligmann, J, Smith, A, Teo, M, Webb, EJ, Webster, A, West, N, Sebag-Montefiore, D, Gollins, S, Appelt, AL

Publikováno v: BMJ Open. 12:e049119

IntroductionThe standard of care for patients with localised rectal cancer is radical surgery, often combined with preoperative neoadjuvant (chemo)radiotherapy. While oncologically effective, this treatment strategy is associated with operative morta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258ac595ef808ac3936b357f849377fb
https://doi.org/10.1136/bmjopen-2021-049119

Prognostic Value of Serum NPY Hypermethylation in Neoadjuvant Chemoradiotherapy for Rectal Cancer: Secondary Analysis of a Randomized Trial

Autor: Appelt, AL, Andersen, RF, Lindebjerg, J, Jakobsen, A

Objectives: Long-term prevention of metastatic disease remains a challenge in locally advanced rectal cancer, and robust pretreatment prognostic factors for metastatic progression are lacking. We hypothesized that detecting circulating tumor-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::6f0afdc8bb87aadbea74ea70045f6fe4

Reirradiation - still navigating uncharted waters?

Autor: Andratschke N; Department of Radiation Oncology, University Hospital of Zurich, University of Zurich, Switzerland., Willmann J; Department of Radiation Oncology, University Hospital of Zurich, University of Zurich, Switzerland., Appelt AL; Leeds Institute of Medical Research at St James's, University of Leeds, UK.; Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, UK., Day M; Department of Radiation Oncology, University Hospital of Zurich, University of Zurich, Switzerland., Kronborg C; Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Massaccesi M; Department of Radiology, Radiation Oncology and Hematology, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy., Ozsahin M; Hôpital Riviera-Chablais, Rennaz, Switzerland., Pasquier D; Academic Department of Radiation Oncology, Centre O Lambret, Lille, France.; University of Lille, Centrale Lille, CNRS, CRIStAL UMR 9189, Lille, France., Petric P; Department of Radiation Oncology, University Hospital of Zurich, University of Zurich, Switzerland., Riesterer O; Cantonal Hospital Aarau, Aarau, Switzerland., De Ruysscher D; Maastricht University Medical Center+, Department of Radiation Oncology (Maastro), GROW School and Erasmus MC Cancer Institute, University Medical Center Rotterdam, the Netherlands., M Van der Velden J; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Guckenberger M; Department of Radiation Oncology, University Hospital of Zurich, University of Zurich, Switzerland.

Publikováno v: Clinical and translational radiation oncology [Clin Transl Radiat Oncol] 2024 Oct 02; Vol. 49, pp. 100871. Date of Electronic Publication: 2024 Oct 02 (Print Publication: 2024).

Multi-centre evaluation of variation in cumulative dose assessment in reirradiation scenarios.

Autor: Hardcastle N; Physical Sciences, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia. Electronic address: nick.hardcastle@petermac.org., Vasquez Osorio E; Division of Cancer Sciences, The University of Manchester, Manchester, UK., Jackson A; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mayo C; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Aarberg AE; Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway., Ayadi M; Department of Radiation Oncology, Physics Unit, Centre Léon Bérard, Lyon, France., Belosi F; Department of Radiation Oncology, University Hospital and University of Zurich, Zurich, Switzerland., Ceylan C; Department of Radiation Oncology, Istanbul Oncology Hospital, Istanbul, Turkey; Department of Medical Physics, University of Yeditepe, Istanbul, Turkey., Davey A; Division of Cancer Sciences, The University of Manchester, Manchester, UK., Dupuis P; Department of Radiation Oncology, Physics Unit, Centre Léon Bérard, Lyon, France., Handley JC; The Christie NHS Foundation Trust, Manchester, UK., Hemminger T; Brainlab Corporate Services GmbH, Munich, Germany., Hoffmann L; Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark., Kelly C; St Luke's Radiation Oncology Network, Dublin, Ireland., Michailidou C; Department of Medical Physics, German Oncology Center, Limassol, Cyprus., Muscat S; Department of Medical Physics, Portsmouth Hospitals University NHS Trust, Portsmouth, UK., Murrell DH; Department of Oncology, Western University, London, Ontario, Canada; London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada., Pérez-Alija J; Servei de Radiofísica i Radioprotecció, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Palmer C; Department of Radiotherapy Physics, Norfolk and Norwich University Hospitals, NHS Foundation Trust, UK., Placidi L; Department of Radiology, Radiation Oncology and Hematology, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy., Popovic M; Department of Medical Physics, McGill University Health Centre, Montreal, Quebec, Canada., Rønde HS; Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark., Selby A; South West Wales Cancer Centre, Swansea, Wales, UK., Skopidou T; Guy's and St Thomas' NHS Foundation Trust, London, UK., Solomou N; Department of Radiotherapy Physics, Norfolk and Norwich University Hospitals, NHS Foundation Trust, UK., Stroom J; Department of Radiation Oncology, Champalimaud Centre for the Unknown, Lisbon, Portugal., Thompson C; Department of Medical Physics, Leeds Teaching Hospitals NHS Trust, Leeds, UK., West NS; Northern Centre for Cancer Care, Newcastle upon Tyne, UK., Zaila A; Biomedical Physics Department, King Faisal Specialist Hospital and Research Center (KFSHRC), Riyadh, Saudi Arabia., Appelt AL; Department of Medical Physics, Leeds Teaching Hospitals NHS Trust, Leeds, UK; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.

Publikováno v: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2024 May; Vol. 194, pp. 110184. Date of Electronic Publication: 2024 Mar 05.

Early radiologic and metabolic tumour response assessment during combined chemo-radiotherapy for locally advanced NSCLC.

Autor: Tvilum M; Department of Oncology, Aarhus University Hospital, Denmark.; Danish Center for Particle Therapy, Aarhus University Hospital, Denmark., Knap MM; Department of Oncology, Aarhus University Hospital, Denmark., Hoffmann L; Department of Oncology, Aarhus University Hospital, Denmark.; Department of Clinical Medicine, Faculty of Health Sciences, Aarhus University, Denmark., Khalil AA; Department of Oncology, Aarhus University Hospital, Denmark., Appelt AL; Leeds Institute of Medical Research at St James's, University of Leeds, United Kingdom.; Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom., Haraldsen A; Department of Nuclear Medicine and PET-centre, Aarhus University Hospital, Denmark., Alber M; Department of Radiation Oncology, Heidelberg University Hospital, Germany.; Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg University Hospital, Germany., Grau C; Danish Center for Particle Therapy, Aarhus University Hospital, Denmark., Schmidt HH; Department of Oncology, Aarhus University Hospital, Denmark., Kandi M; Department of Oncology, Aarhus University Hospital, Denmark., Holt MI; Department of Clinical Genetics, Sygehus Lillebaelt, Vejle, Denmark., Lutz CM; Department of Oncology, Aarhus University Hospital, Denmark., Møller DS; Department of Oncology, Aarhus University Hospital, Denmark.; Department of Clinical Medicine, Faculty of Health Sciences, Aarhus University, Denmark.

Publikováno v: Clinical and translational radiation oncology [Clin Transl Radiat Oncol] 2024 Jan 23; Vol. 45, pp. 100737. Date of Electronic Publication: 2024 Jan 23 (Print Publication: 2024).