Correction: Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography.

Autor: Krogager ML, Skals RK, Appel EVR, Schnurr TM, Engelbrechtsen L, Have CT, Pedersen O, Engstrøm T, Roden DM, Gislason G, Poulsen HE, Køber L, Stender S, Hansen T, Grarup N, Andersson C, Torp-Pedersen C, Weeke PE

Publikováno v: PloS one [PLoS One] 2023 Oct 26; Vol. 18 (10), pp. e0293765. Date of Electronic Publication: 2023 Oct 26 (Print Publication: 2023).

The trans-ancestral genomic architecture of glycemic traits.

Autor: Chen J; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, USA., Marenne G; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.; Inserm, Univ Brest, EFS, UMR 1078, GGB, Brest, France., Varshney A; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Corbin LJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Willems SM; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Zhang X; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Biostatistics, School of Public Health, Shandong University, Jinan, China., Horikoshi M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Laboratory for Genomics of Diabetes and Metabolism, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan., Boutin TS; Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, Edinburgh, UK., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Waage J; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Chan KHK; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA.; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China.; Department of Electrical Engineering, City University of Hong Kong, Hong Kong SAR, China., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Anasanti MD; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Chu AY; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Claringbould A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Heikkinen J; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Hong J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Hottenga JJ; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Huo S; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Kaakinen MA; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Section of Statistical Multi-omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, UK., Louie T; Department of Biostatistics, University of Washington, Seattle, WA, USA., März W; SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria.; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany., Moreno-Macias H; Department of Economics, Metropolitan Autonomous University, Mexico City, Mexico., Ndungu A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Nelson SC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., North KE; CVD Genetic Epidemiology Computational Laboratory, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Raulerson CK; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Ray D; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Rohde R; CVD Genetic Epidemiology Computational Laboratory, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; HPI Digital Health Center, Digital Health and Personalized Medicine, Hasso Plattner Institute, Potsdam, Germany., Sim X; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Southam L; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Stewart ID; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wang CA; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, New South Wales, Australia., Wang Y; CVD Genetic Epidemiology Computational Laboratory, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Wu P; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK., Ahluwalia TS; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Appel EVR; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Brody JA; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Burtt NP; Metabolism Program, Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Cabrera CP; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Cade BE; Department of Medicine, Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Sleep Medicine, Harvard Medical School, Boston, MA, USA., Chai JF; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore., Chai X; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore., Chang LC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen BH; Department of Epidemiology, The Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA., Chitrala KN; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Chiu YF; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan., de Haan HG; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany., Demirkan A; Section of Statistical Multi-omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, UK.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Duan Q; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Statistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Engmann J; Institute of Cardiovascular Science, University College London, London, UK., Fatumo SA; Uganda Medical Informatics Centre (UMIC), MRC/UVRI and London School of Hygiene & Tropical Medicine (Uganda Research Unit), Entebbe, Uganda.; London School of Hygiene & Tropical Medicine, London, UK.; H3Africa Bioinformatics Network (H3ABioNet) Node, Centre for Genomics Research and Innovation, NABDA/FMST, Abuja, Nigeria., Gayán J; Bioinfosol, Sevilla, Spain., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gong JH; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA., Gustafsson S; Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Hai Y; Department of Statistics, The University of Auckland, Science Center, Auckland, New Zealand., Hartwig FP; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., He J; Department of Medicine, Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Heianza Y; Department of Epidemiology, Tulane University Obesity Research Center, Tulane University, New Orleans, LA, USA., Huang T; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China., Huerta-Chagoya A; Molecular Biology and Genomic Medicine Unit, National Council for Science and Technology, Mexico City, Mexico.; Molecular Biology and Genomic Medicine Unit, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico., Hwang MY; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Jensen RA; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kentistou KA; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany., Kooner IK; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK., Lai S; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA., Lange LA; Department of Medicine, Divison of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA., Langefeld CD; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA., Lauzon M; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Li M; Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA., Ligthart S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Liu J; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Lyssenko V; Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmo, Sweden., Mangino M; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK., Marzi C; Institute of Epidemiology, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Montasser ME; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA., Nag A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Nakatochi M; Public Health Informatics Unit, Department of Integrated Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Noce D; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Pistis G; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Raffield L; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Robertson NR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Ryan K; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA., Sanna S; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy., Saxena R; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Schraut KE; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Sennblad B; Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Setoh K; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Icelandic Heart Association, Kopavogur, Iceland., Sparsø T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Strawbridge RJ; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.; Department of Medicine Solna, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden., Takeuchi F; National Center for Global Health and Medicine, Tokyo, Japan., Tan J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., van den Akker E; Department of Biomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, the Netherlands.; Department of Biomedical Data Sciences, Leiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Genomics PLC, Oxford, UK., Vogel M; Center of Pediatric Research, University Children's Hospital Leipzig, University of Leipzig Medical Center, Leipzig, Germany., Wang H; Department of Medicine, Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Sleep Medicine, Harvard Medical School, Boston, MA, USA., Wang C; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Wang N; Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; University of Southern California Diabetes and Obesity Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Warren HR; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, UIT the Arctic University of Norway, Tromsø, Norway., Wong A; MRC Unit for Lifelong Health and Ageing at University College London, London, UK., Wood AR; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Xie T; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zafarmand MH; Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Zhao JH; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Amin N; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Arzumanyan Z; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Astrup A; Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Bakker SJL; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Baldassarre D; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.; Centro Cardiologico Monzino, IRCCS, Milan, Italy., Beekman M; Department of Biomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bertoni A; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Blüher M; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institues of Health, Bethesda, MD, USA., Bornstein SR; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Cai Q; Department of Medicine, Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Chang YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan., de Geus EJC; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Dehghan A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Du S; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Farmaki AE; Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK.; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece., Frånberg M; Department of Medicine Solna, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden., Fuchsberger C; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Gao Y; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China., Gjesing AP; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Han S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Hartman CA; Department of Psychiatry, Interdisciplinary Center Psychopathy and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Herder C; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Düsseldorf, Germany., Hicks AA; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Hsieh CH; Internal Medicine, Endocrine and Metabolism, Tri-Service General Hospital, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Hsueh WA; Internal Medicine, Endocrinology, Diabetes and Metabolism, Diabetes and Metabolism Research Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan., Igase M; Department of Anti-aging Medicine, Ehime University Graduate School of Medicine, Toon, Japan., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Johnson WC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Jørgensen ME; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; National Institute of Public Health, University of Southern Denmark, Odense, Denmark., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Kalyani RR; Department of Medicine, Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kandeel FR; Clinical Diabetes, Endocrinology and Metabolism, Translational Research and Cellular Therapeutics, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Kiess W; Center of Pediatric Research, University Children's Hospital Leipzig, University of Leipzig Medical Center, Leipzig, Germany., Kolcic I; Department of Public Health, University of Split School of Medicine, Split, Croatia., Kuulasmaa T; Institute of Biomedicine, Bioinformatics Center, Univeristy of Eastern Finland, Kuopio, Finland., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Läll K; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Lam K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Lawlor DA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Lee NR; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, the Philippines.; Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, the Philippines., Lemaitre RN; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Li H; State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Lin SY; Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan.; National Defense Medical Center, National Yang-Ming University, Taipei, Taiwan., Lindström J; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Lorenzo C; Department of Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA., Matsubara T; Department of Internal Medicine, Aichi Gakuin University School of Dentistry, Nagoya, Japan., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Mingrone G; Department of Diabetes, Diabetes, and Nutritional Sciences, James Black Centre, King's College London, London, UK., Mooijaart S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Moon S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan., Nadkarni GN; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nadler JL; Department of Medicine and Pharmacology, New York Medical College School of Medicine, Valhalla, NY, USA., Nelis M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Neville MJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Norris JM; Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Ohyagi Y; Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Toon, Japan., Peters A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians University Munich, Munich, Germany., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Polasek O; Department of Public Health, University of Split School of Medicine, Split, Croatia.; Gen-Info, Zagreb, Croatia., Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Raven D; Department of Psychiatry, Interdisciplinary Center Psychopathy and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Reilly DF; Genetics and Pharmacogenomics, Merck Sharp & Dohme, Kenilworth, NJ, USA., Reiner A; Department of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Rivideneira F; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Roll K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rudan I; Centre for Global Health, The Usher Institute, University of Edinburgh, Edinburgh, UK., Sabanayagam C; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Sandow K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Sattar N; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Schürmann A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Shi J; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Academy of Science & Technology (SAST), Shanghai, China., Stringham HM; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Teslovich TM; Sarepta Therapeutics, Cambridge, MA, USA., Thuesen B; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Timmers PRHJ; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Tremoli E; Centro Cardiologico Monzino, IRCCS, Milan, Italy., Tsai MY; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Uitterlinden A; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., van Dam RM; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Nutrition, Harvard T. H. 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Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Zemunik T; Department of Human Biology, University of Split School of Medicine, Split, Croatia., Abecasis GR; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Aguilar-Salinas CA; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.; Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición and Tec Salud, Mexico City, Mexico.; Instituto Tecnológico y de Estudios Superiores de Monterrey Tec Salud, Monterrey, Mexico., Alarcón-Riquelme ME; Department of Medical Genomics, Pfizer/University of Granada/Andalusian Government Center for Genomics and Oncological Research (GENYO), Granada, Spain.; Institute for Environmental Medicine, Chronic Inflammatory Diseases, Karolinska Institutet, Solna, Sweden., An P; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA., Aviles-Santa L; Clinical and Health Services Research, National Institute on Minority Health and Health Disparities, Bethesda, MD, USA., Becker DM; Department of Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Beilin LJ; Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Western Australia, Australia., Bergmann S; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Black C; Aberdeen Centre for Health Data Science, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK., Boehnke M; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Boerwinkle E; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Böhm BO; Division of Endocrinology and Diabetes, Graduate School of Molecular Endocrinology and Diabetes, University of Ulm, Ulm, Germany.; LKC School of Medicine, Nanyang Technological University, Singapore and Imperial College London, UK, Singapore, Singapore., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Boomsma DI; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Digital Health Center, Hasso Plattner Institut, University Potsdam, Potsdam, Germany., Buchanan TA; University of Southern California Diabetes and Obesity Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; Department of Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; Department of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Canouil M; 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Department of Clinical Sciences, Lund University, Malmö, Sweden., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Ferrannini E; CNR Institute of Clinical Physiology, Pisa, Italy., Ferrucci L; Intramural Research Program, National Institute of Aging, Baltimore, MD, USA., Florez JC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Franks PW; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmo, Sweden.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Frayling TM; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Froguel P; 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Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Leander K; Institute of Environmental Medicine, Cardiovascular and Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden., Li H; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Lin X; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Lind L; Department of Medical Sciences, University of Uppsala, Uppsala, Sweden., Lindgren C; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK., Liu S; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Magnusson PKE; Department of Medical Epidemiology and Biostatistics and the Swedish Twin Registry, Karolinska Institutet, Stockholm, Sweden., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Metspalu A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Mook-Kanamori DO; 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MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Palmer CNA; Division of Population Health and Genomics, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pennell CE; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, New South Wales, Australia., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Pramstaller PP; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Province MA; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA., Psaty BM; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Qi L; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Raffel LJ; Department of Pediatrics, Genetic and Genomic Medicine, University of California, Irvine, Irvine, CA, USA., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Redline S; Department of Medicine, Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Sleep Medicine, Harvard Medical School, Boston, MA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Havard Medical School, Boston, MA, USA., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Saaristo TE; Tampere, Finnish Diabetes Association, Tampere, Finland.; Pirkanmaa Hospital District, Tampere, Finland., Sandhu M; Department of Medicine, University of Cambridge, Cambridge, UK., Saramies J; South Karelia Central Hospital, Lappeenranta, Finland., Schneiderman N; Department of Psychology, University of Miami, Miami, FL, USA., Schwarz P; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich, University Hospital and Faculty of Medicine, Dresden, Germany., Scott LJ; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Selvin E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Sever P; National Heart and Lung Institute, Imperial College London, London, UK., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Slagboom PE; Department of Biomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Small KS; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK., Smith BH; Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Sofer T; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Sørensen TIA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Spector TD; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK., Stanton A; Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., Steves CJ; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.; Department of Ageing and Health, Guy's and St Thomas' NHS Foundation Trust, London, UK., Stumvoll M; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Sun L; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Tai ES; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Cardiovascular and Metabolic Disease Signature Research Program, Duke-NUS Medical School, Singapore, Singapore., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Tönjes A; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Tuomilehto J; Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Tusie T; Molecular Biology and Genomic Medicine Unit, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico.; Department of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., van der Harst P; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., van Duijn C; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Vitart V; Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Vrijkotte TGM; Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Wagenknecht LE; Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Walker M; Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Wang YX; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; University of Southern California Diabetes and Obesity Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; Department of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wei WB; Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Willemsen G; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wong TY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Xiang AH; Department of Research and Evaluation, Kaiser Permanente of Southern California, Pasadena, CA, USA., Yanek LR; Department of Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yengo L; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia., Yokota M; Kurume University School of Medicine, Kurume, Japan., Zeggini E; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Gloyn AL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Meigs JB; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Scott RA; 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Publikováno v: Nature genetics [Nat Genet] 2021 Jun; Vol. 53 (6), pp. 840-860. Date of Electronic Publication: 2021 May 31.

Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes.

Autor: Miguel-Escalada I; Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, London, UK.; Regulatory Genomics and Diabetes, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Madrid, Spain.; Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain., Bonàs-Guarch S; Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, London, UK.; Regulatory Genomics and Diabetes, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Madrid, Spain.; Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain., Cebola I; Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, London, UK., Ponsa-Cobas J; Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, London, UK., Mendieta-Esteban J; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain., Atla G; Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, London, UK.; Regulatory Genomics and Diabetes, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Madrid, Spain.; Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain., Javierre BM; Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK.; Josep Carreras Leukaemia Research Institute, Campus ICO-Germans Trias i Pujol, Barcelona, Spain., Rolando DMY; Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, London, UK., Farabella I; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain., Morgan CC; Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research Imperial Biomedical Research Centre, Imperial College London, London, UK.; Regulatory Genomics and Diabetes, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain., García-Hurtado J; Regulatory Genomics and Diabetes, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Madrid, Spain.; 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Publikováno v: Nature genetics [Nat Genet] 2019 Jul; Vol. 51 (7), pp. 1137-1148. Date of Electronic Publication: 2019 Jun 28.

Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography.

Autor: Lukács Krogager M; Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark., Skals RK; Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark., Appel EVR; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Schnurr TM; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Engelbrechtsen L; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Have CT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Engstrøm T; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Roden DM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., Gislason G; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Hellerup, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Danish Heart Foundation, Copenhagen, Denmark.; The National Institute of Public Health, University of Southern Denmark, Odense, Denmark., Poulsen HE; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Laboratory of Clinical Pharmacology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Køber L; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Stender S; Department of Nutrition, Exercize and Sports, Copenhagen University, Frederiksberg, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Andersson C; Department of Cardiology, Herlev and Gentofte Hospital, Hellerup, Denmark., Torp-Pedersen C; Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Weeke PE; Department of Cardiology, Bispebjerg and Frederiksberg Hospital, Denmark.

Publikováno v: PloS one [PLoS One] 2018 Dec 19; Vol. 13 (12), pp. e0208645. Date of Electronic Publication: 2018 Dec 19 (Print Publication: 2018).

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.

Autor: Gilly A; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom., Suveges D; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom., Kuchenbaecker K; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Division of Psychiatry, University College of London, London, W1T 7NF, United Kingdom.; UCL Genetics Institute, University College London, London, WC1E 6BT, United Kingdom., Pollard M; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, United Kingdom., Southam L; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom., Hatzikotoulas K; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany., Farmaki AE; Department of Health Sciences, College of Life Sciences, University of Leicester, Leicester, LE1 6TP, United Kingdom.; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, 176-71, Greece., Bjornland T; Department of Mathematical Sciences, Norwegian Institute of Science and Technology, Trondheim, 7491, Norway., Waples R; The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, 2200, Denmark., Appel EVR; Section for Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, 2200, Denmark., Casalone E; Human Genetics Foundation, University of Torino, Torino, IT-10126, Italy., Melloni G; Department of Biomedical Informatics, Harvard Medical School, Boston, 02115, MA, USA., Kilian B; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom., Rayner NW; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Old Road, Headington, Oxford, OX3 7LE, United Kingdom., Ntalla I; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, United Kingdom., Kundu K; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Department of Haematology, Cambridge Biomedical Campus, University of Cambridge, Long Road, Cambridge, CB2 0PT, United Kingdom., Walter K; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom., Danesh J; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, University of Cambridge, Cambridge, CB1 8RN, United Kingdom.; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Wort's Causeway, University of Cambridge, Strangeways Research Laboratory, Cambridge, CB1 8RN, United Kingdom., Butterworth A; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, University of Cambridge, Cambridge, CB1 8RN, United Kingdom.; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Wort's Causeway, University of Cambridge, Strangeways Research Laboratory, Cambridge, CB1 8RN, United Kingdom.; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom., Barroso I; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom., Tsafantakis E; Anogia Medical Centre, Anogia, 740 51, Greece., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, 176-71, Greece., Moltke I; The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, 2200, Denmark., Zeggini E; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom. Eleftheria@sanger.ac.uk.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany. Eleftheria@sanger.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2018 Nov 07; Vol. 9 (1), pp. 4674. Date of Electronic Publication: 2018 Nov 07.