Development of an adipose-tropic AAV capsid ablating liver tropism

Autor: Huang, Wei, Bates, Rhiannon, Appana, Bhavya, Mohammed, Tawfiq, Cao, Lei

Publikováno v: In iScience 18 October 2024 27(10)

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Visceral adipose tissue-directed FGF21 gene therapy improves metabolic and immune health in BTBR mice.

Autor: Queen NJ; Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA., Bates R; Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA., Huang W; Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA., Xiao R; Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA., Appana B; Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA., Cao L; Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2020 Dec 25; Vol. 20, pp. 409-422. Date of Electronic Publication: 2020 Dec 25 (Print Publication: 2021).