Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Apostolos Gkazepis"'
1
Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1
Autor: Karin Mengele, Fred C.G.J. Sweep, Apostolos Gkazepis, Manfred Schmitt, Rudolf Napieralski, Ute Reuning, Nils Brünner, John A. Foekens, Nadia Harbeck, Viktor Magdolen
Publikováno v: Expert Review of Molecular Diagnosis, 10(8), 1051-1067. Taylor & Francis Ltd
Expert Review of Molecular Diagnostics, 10, 1051-67
Expert Review of Molecular Diagnostics, 10, 8, pp. 1051-67
Item does not contain fulltext The prognostic and/or predictive value of the cancer biomarkers, urokinase-type plasminogen activator (uPA) and its inhibitor (plasminogen activator inhibitor [PAI]-1), determined by ELISA in tumor-tissue extracts, was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22de4925770a2be6145bead4ab0bcf31
https://doi.org/10.1586/erm.10.71
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2
Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1
Autor: John A. Foekens, Karin Mengele, Fred C.G.J. Sweep, Viktor Magdolen, Nadia Harbeck, Manfred Schmitt, Rudolf Napieralski, Ute Reuning, Nils Brünner, Apostolos Gkazepis
Publikováno v: Expert Review of Molecular Diagnosis, 10(7), 947-962. Taylor & Francis Ltd
Expert Review of Molecular Diagnostics, 10, 947-62
Expert Review of Molecular Diagnostics, 10, 7, pp. 947-62
Item does not contain fulltext In cancer, the serine protease urokinase-type plasminogen activator, its inhibitor (plasminogen activator inhibitor type-1) and the receptor (CD87), among other proteolytic factors, are involved in tumor cell disseminat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab22b7a5c3207292fb9b296acf5258e4
https://hdl.handle.net/2066/87856
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3
Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines
Autor: Cecylia Giersig, Christina Yfanti, Daniela Hellmann, Gregor Weirich, Anita Welk, Wen-Liang Kuo, Marsha Rich Rosner, Apostolos Gkazepis, Karin Mengele, Wei-Jen Tang, Manfred Schmitt
Publikováno v: bchm. 389:1441-1445
Immunohistochemical evidence of ubiquitous distribution of the metalloprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cells is presented. Immunohistochemical staining was performed on a multi-organ tissue m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad069169b3e273b89d3c2457e93f5370
https://doi.org/10.1515/bc.2008.157
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4
Clinical value of protein expression of kallikrein-related peptidase 7 (KLK7) in ovarian cancer
Autor: Manfred Schmitt, Eleftherios P. Diamandis, Matthias Kotzsch, Katharina Mayer, Viktor Magdolen, Apostolos Gkazepis, Marion Kiechle, Corinna Propping, Marcus Kremer, Karin Mengele, Julia Dorn
Publikováno v: Biological chemistry. 395(1)
Expression of the kallikrein-related peptidase 7 (KLK7) is dysregulated in ovarian cancer. We assessed KLK7 expression by ELISA and quantitative immunohistochemistry and analyzed its association with clinicopathological parameters and patients’ out
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79a323a185ff4e42683da1267c0aa3a
https://pubmed.ncbi.nlm.nih.gov/23999494
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5
Somatic copy number changes in DPYD are associated with lower risk of recurrence in triple-negative breast cancers
Autor: Alfons Meindl, C. Meul, Nicolai Grebenchtchikov, Apostolos Gkazepis, M. Schmitt, S. Raab, Stephanie Avril, Michaela Aubele, Eva Gross, A. B. P. Van Kuilenburg, Tibor Schuster, Raymon Vijzelaar, Judith Meijer, Marion Kiechle, Corinna Propping
Publikováno v: British journal of cancer, 109(9), 2347-2355. Nature Publishing Group
Br. J. Cancer 109, 2347-2355 (2013)
British Journal of Cancer
Background: Genomic rearrangements at the fragile site FRA1E may disrupt the dihydropyrimidine dehydrogenase gene (DPYD) which is involved in 5-fluorouracil (5-FU) catabolism. In triple-negative breast cancer (TNBC), a subtype of breast cancer freque
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6617b15a1f2311f0dbad1bf4cadaa3
https://pure.amc.nl/en/publications/somatic-copy-number-changes-in-dpyd-are-associated-with-lower-risk-of-recurrence-in-triplenegative-breast-cancers(aaad56b7-99c6-4dc0-b85c-f876001ff39d).html
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6
Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients
Autor: Barbara Schmalfeldt, Manfred Schmitt, Rupert Langer, Nicolai Grebenchtchikov, Viktor Magdolen, Jane Bayani, Marion Kiechle, Matthias Kotzsch, Fred C.G.J. Sweep, Apostolos Gkazepis, Lina Seiz, Julia Dorn, Axel Walch, Eleftherios P. Diamandis
Publikováno v: Biological Chemistry, 393, 391-401
Biological Chemistry, 393, 5, pp. 391-401
Seiz, Lina; Dorn, Julia; Kotzsch, Matthias; Walch, Axel; Grebenchtchikov, Nicolai I; Gkazepis, Apostolos; Schmalfeldt, Barbara; Kiechle, Marion; Bayani, Jane; Diamandis, Eleftherios P; Langer, Rupert; Sweep, Fred C G J; Schmitt, Manfred; Magdolen, Viktor (2012). Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients. Biological chemistry, 393(5), pp. 391-401. Berlin: De Gruyter 10.1515/hsz-2011-0264
Several members of the human kallikrein-related peptidase family, including KLK6, are up-regulated in ovarian cancer. High KLK6 mRNA or protein expression, measured by quantitative polymerase chain reaction and enzyme-linked immunoassay, respectively
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08868110a4cf8c15a5f7368e094cd36
https://doi.org/10.1515/hsz-2011-0264
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7
Impact of expression differences of kallikrein-related peptidases and of uPA and PAI-1 between primary tumor and omentum metastasis in advanced ovarian cancer
Autor: Barbara Schmalfeldt, Ronald E. Kates, Apostolos Gkazepis, Marion Kiechle, Eleftherios P. Diamandis, Nadia Harbeck, Manfred Schmitt, Andreas Scorilas, Julia Dorn, Antoninus Soosaipillai
Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 22(4)
Primary tumor levels of serine proteases of the kallikrein-related peptidases (KLK) family as well as urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 impact disease course in ovarian cancer. The changes in levels of these factors f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fbfd0c7ebb51fbf84c5953ae15c45d
https://pubmed.ncbi.nlm.nih.gov/20924077
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8
Assessment of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in Breast Cancer Tissue: Historical Aspects and Future Prospects
Autor: Rudolf Napieralski, Manfred Schmitt, Karin Mengele, Viktor Magdolen, Nadia Harbeck, Ute Reuning, Apostolos Gkazepis
Publikováno v: Breast care (Basel, Switzerland). 3(s2)
centration of tPA in plasma amounts to 5–10 ng/ml, but varies strongly under different physiological and pathological conditions. Although it was already known before 1970 that plasminogen activator activity may be increased in tumour tissues over
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9d1d26e4e056a6ea9dd8e0ae47facb
https://pubmed.ncbi.nlm.nih.gov/20824007
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