Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Apostolos Gkatzionis"'
Autor:
Ruth E Mitchell, April E Hartley, Venexia M Walker, Apostolos Gkatzionis, James Yarmolinsky, Joshua A Bell, Amanda H W Chong, Lavinia Paternoster, Kate Tilling, George Davey Smith
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010596 (2023)
Genetic studies of disease progression can be used to identify factors that may influence survival or prognosis, which may differ from factors that influence on disease susceptibility. Studies of disease progression feed directly into therapeutics fo
Externí odkaz:
https://doaj.org/article/373805b430d748c78a601514eae3f3a2
Autor:
Opeyemi Soremekun, Ville Karhunen, Yiyan He, Skanda Rajasundaram, Bowen Liu, Apostolos Gkatzionis, Chisom Soremekun, Brenda Udosen, Hanan Musa, Sarah Silva, Christopher Kintu, Richard Mayanja, Mariam Nakabuye, Tafadzwa Machipisa, Amy Mason, Marijana Vujkovic, Verena Zuber, Mahmoud Soliman, Joseph Mugisha, Oyekanmi Nash, Pontiano Kaleebu, Moffat Nyirenda, Tinashe Chikowore, Dorothea Nitsch, Stephen Burgess, Dipender Gill, Segun Fatumo
Publikováno v:
EBioMedicine, Vol 78, Iss , Pp 103953- (2022)
Summary: Background: Dyslipidaemia is highly prevalent in individuals with type 2 diabetes mellitus (T2DM). Numerous studies have sought to disentangle the causal relationship between dyslipidaemia and T2DM liability. However, conventional observatio
Externí odkaz:
https://doaj.org/article/8da632d3429846caadce373d935afae1
Autor:
Dipender Gill, Marios K. Georgakis, Venexia M. Walker, A. Floriaan Schmidt, Apostolos Gkatzionis, Daniel F. Freitag, Chris Finan, Aroon D. Hingorani, Joanna M.M. Howson, Stephen Burgess, Daniel I. Swerdlow, George Davey Smith, Michael V. Holmes, Martin Dichgans, Robert A Scott, Jie Zheng, Bruce M. Psaty, Neil M. Davies
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that encode drug targets can be u
Externí odkaz:
https://doaj.org/article/94d121c8d8d24f8ebd46a86697702bce
Autor:
Stephen Burgess, Amy M. Mason, Andrew J. Grant, Eric A.W. Slob, Apostolos Gkatzionis, Verena Zuber, Ashish Patel, Haodong Tian, Cunhao Liu, William G. Haynes, G. Kees Hovingh, Lotte Bjerre Knudsen, John C. Whittaker, Dipender Gill
Publikováno v:
American journal of human genetics. 110(2):195-214
Evidence on the validity of drug targets from randomized trials is reliable but typically expensive and slow to obtain. In contrast, evidence from conventional observational epidemiological studies is less reliable because of the potential for bias f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24c391d41cbb6c76d403e7b379eec23
https://doi.org/10.1016/j.ajhg.2022.12.017
https://doi.org/10.1016/j.ajhg.2022.12.017
Autor:
Michael Lawton, Yoav Ben-Shlomo, Apostolos Gkatzionis, Michele T. Hu, Donald Grosset, Kate Tilling
Identifying factors that are causes of disease progression, especially in neurodegenerative diseases, is of considerable interest. Disease progression can be described as a trajectory of outcome over time - for example, a linear trajectory having bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f1fc677eb807f90631d37bbe3f9b31
https://doi.org/10.1101/2023.04.27.23289203
https://doi.org/10.1101/2023.04.27.23289203
Observational studies are rarely representative of their target population, because there are known and unknown factors that affect an individual’s choice to participate (known as the selection mechanism). Selection can cause bias in a given analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c4e38d91e6ace04856d9bab7f528297
https://doi.org/10.1101/2023.04.04.23288120
https://doi.org/10.1101/2023.04.04.23288120
Autor:
Ruth E. Mitchell, April E. Hartley, Venexia M. Walker, Apostolos Gkatzionis, James Yarmolinsky, Joshua A. Bell, Amanda H. W. Chong, Lavinia Paternoster, Kate Tilling, George Davey Smith
Genetic studies of disease progression can be used to identify factors that may influence survival or prognosis, which may differ from factors which influence on disease susceptibility. Studies of disease progression feed directly into therapeutics f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284d332c2f7788460531ee02165c518f
https://doi.org/10.1101/2022.04.22.22274166
https://doi.org/10.1101/2022.04.22.22274166
Autor:
J. M. Tyrrell, Grace M. Power, G Davey Smith, Si Fang, Jon Heron, Tom G. Richardson, Apostolos Gkatzionis
Background Weight change is a major indicator of adverse health outcomes. This study aims to examine factors contributing to weight change over a one-year interval in midlife. Methods Observational and one-sample Mendelian randomisation (MR) analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcfa31668fbf6c19b1e8e87176df5f41
https://doi.org/10.1101/2021.07.21.21260895
https://doi.org/10.1101/2021.07.21.21260895
Autor:
Verena Zuber, Simon Jones, Mark J. Ponsford, Cristen J. Willer, Amy M. Mason, Luke S. P. Moore, Robyn E Wootton, Bjørn Olav Åsvold, Ben Michael Brumpton, Neil M Davies, Tormod Rogne, Erik Solligård, Humaira Rasheed, Kristian Hveem, Jan Kristian Damås, Dipender Gill, Stephen Burgess, Andrew J. Grant, Apostolos Gkatzionis, Venexia M Walker, Segun Fatumo
Publikováno v:
Ponsford, M, Gkatzionis, A, Walker, V M, Grant, A, Wootton, R, Moore, L, Fatumo, S, Mason, A, Zuber, V, Willer, C, Rasheed, H, Brumpton, B, Hveem, K, Damas, J K, Davies, N M, Asvold, B O, Jones, S, Burgess, S, Rogne, T & Gill, D 2020, ' Cardiometabolic traits, sepsis and severe covid-19 : a Mendelian randomization investigation ', Circulation, vol. 142, no. 18, pp. 1791–1793 . https://doi.org/10.1161/CIRCULATIONAHA.120.050753
[No Abstract]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c9cfd47cbefd85f81980459327e6ef
https://doi.org/10.1161/circulationaha.120.050753
https://doi.org/10.1161/circulationaha.120.050753
Autor:
Venexia M Walker, Jie Zheng, A. Floriaan Schmidt, George Davey Smith, Daniel I. Swerdlow, Dipender Gill, Neil M Davies, Michael V. Holmes, Apostolos Gkatzionis, Robert A. Scott, Martin Dichgans, Daniel F. Freitag, Bruce M. Psaty, Marios K. Georgakis, Aroon D. Hingorani, Joanna M M Howson, Stephen Burgess, Chris Finan
Publikováno v:
Wellcome Open Research
Gill, D, Georgakis, M K, Walker, V M, Schmidt, A F, Gkatzionis, A, Freitag, D F, Finan, C, Hingorani, A D, Howson, J M M, Burgess, S, Swerdlow, D I, Davey Smith, G, Psaty, B M & Davies, N M 2021, ' Mendelian randomization for studying the effects of perturbing drug targets ', Wellcome Open Research, vol. 6, 16 . https://doi.org/10.12688/wellcomeopenres.16544.2
Gill, D, Georgakis, M K, Walker, V M, Schmidt, A F, Gkatzionis, A, Freitag, D F, Finan, C, Hingorani, A D, Howson, J M M, Burgess, S, Swerdlow, D I, Davey Smith, G, Psaty, B M & Davies, N M 2021, ' Mendelian randomization for studying the effects of perturbing drug targets ', Wellcome Open Research, vol. 6, 16 . https://doi.org/10.12688/wellcomeopenres.16544.2
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that encode drug targets can be u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6800d380ef162c233049a5551cdc4800