Loss of epigenetic information as a cause of mammalian aging.

Autor: Yang JH; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA. Electronic address: jae-hyun_yang@hms.harvard.edu., Hayano M; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA; Department of Ophthalmology, Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan., Griffin PT; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Amorim JA; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA; IIIUC-Institute of Interdisciplinary Research, University of Coimbra, Coimbra, Portugal., Bonkowski MS; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Apostolides JK; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA., Salfati EL; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Blanchette M; Cantata/Dovetail Genomics, Scotts Valley, CA, USA., Munding EM; Cantata/Dovetail Genomics, Scotts Valley, CA, USA., Bhakta M; Cantata/Dovetail Genomics, Scotts Valley, CA, USA., Chew YC; Zymo Research Corporation, Irvine, CA, USA., Guo W; Zymo Research Corporation, Irvine, CA, USA., Yang X; Zymo Research Corporation, Irvine, CA, USA., Maybury-Lewis S; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Tian X; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Ross JM; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Coppotelli G; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Meer MV; Department of Medicine, Brigham and Women's Hospital, HMS, Boston, MA, USA., Rogers-Hammond R; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Vera DL; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Lu YR; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Pippin JW; Division of Nephrology, University of Washington, Seattle, WA, USA., Creswell ML; Division of Nephrology, University of Washington, Seattle, WA, USA; Georgetown University School of Medicine, Washington, DC, USA., Dou Z; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Xu C; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Mitchell SJ; Experimental Gerontology Section, NIA/NIH, Baltimore, MD, USA., Das A; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA; Department of Pharmacology, UNSW, Sydney, NSW, Australia., O'Connell BL; Department of Biomolecular Engineering, UCSC, Santa Cruz, CA, USA., Thakur S; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Kane AE; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Su Q; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA., Mohri Y; Department of Stem Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan., Nishimura EK; Department of Stem Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan., Schaevitz L; Vium, San Mateo, CA, USA., Garg N; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Balta AM; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Rego MA; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Gregory-Ksander M; Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, HMS, Boston, MA, USA., Jakobs TC; Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, HMS, Boston, MA, USA., Zhong L; The Massachusetts General Hospital Cancer Center, HMS, Boston, MA, USA., Wakimoto H; Department of Genetics, HMS, Boston, MA, USA., El Andari J; Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, BioQuant, Heidelberg, Germany., Grimm D; Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, BioQuant, Heidelberg, Germany., Mostoslavsky R; The Massachusetts General Hospital Cancer Center, HMS, Boston, MA, USA., Wagers AJ; Paul F. Glenn Center for Biology of Aging Research, Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; Joslin Diabetes Center, Boston, MA, USA., Tsubota K; Department of Ophthalmology, Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan., Bonasera SJ; Division of Geriatrics, University of Nebraska Medical Center, Durham Research Center II, Omaha, NE, USA., Palmeira CM; Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal., Seidman JG; Department of Genetics, HMS, Boston, MA, USA., Seidman CE; Department of Genetics, HMS, Boston, MA, USA., Wolf NS; Department of Pathology, University of Washington, Seattle, WA, USA., Kreiling JA; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA., Sedivy JM; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA., Murphy GF; Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Green RE; Department of Biomolecular Engineering, UCSC, Santa Cruz, CA, USA., Garcia BA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Berger SL; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA., Oberdoerffer P; Laboratory of Receptor Biology and Gene Expression, NCI, NIH, Bethesda, MD, USA., Shankland SJ; Division of Nephrology, University of Washington, Seattle, WA, USA., Gladyshev VN; Department of Medicine, Brigham and Women's Hospital, HMS, Boston, MA, USA., Ksander BR; Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, HMS, Boston, MA, USA., Pfenning AR; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA., Rajman LA; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA., Sinclair DA; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA. Electronic address: david_sinclair@hms.harvard.edu.

Publikováno v: Cell [Cell] 2023 Jan 19; Vol. 186 (2), pp. 305-326.e27. Date of Electronic Publication: 2023 Jan 12.