Zobrazeno 1 - 10
of 540
pro vyhledávání: '"Apostolia-Maria Tsimberidou"'
Autor:
Elena Fountzilas, Henry Hiep Vo, Peter Mueller, Razelle Kurzrock, Apostolia-Maria Tsimberidou
Publikováno v:
Data in Brief, Vol 51, Iss , Pp 109698- (2023)
We performed a literature search in PubMed to identify phase I/II clinical trials with immunotherapy drugs approved by the Food and Drug Administration (labeled, off-label, and/or combined with investigational immune checkpoint inhibitors or other tr
Externí odkaz:
https://doaj.org/article/ec2da9a982c54d7a864caa226a112f0b
Autor:
Henry Hiep Vo, Siqing Fu, David S. Hong, Daniel D. Karp, Sarina Piha-Paul, Vivek Subbiah, Filip Janku, Aung Naing, Timothy A. Yap, Jordi Rodon, Jaffer A. Ajani, Carrie Cartwright, Amber Johnson, I-Wen Song, Jennifer Beck, Michael Kahle, Graciela M. Nogueras-Gonzalez, Vincent Miller, Calvin Chao, David J. Vining, Donald A. Berry, Funda Meric-Bernstam, Apostolia-Maria Tsimberidou
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-12 (2022)
Abstract We investigated the challenges of conducting IMPACT2, an ongoing randomized study that evaluates molecular testing and targeted therapy (ClinicalTrials.gov: NCT02152254). Patients with metastatic cancer underwent tumor profiling and were ran
Externí odkaz:
https://doaj.org/article/0dcfdec9f8b24bf8a8a6b4c9cca14e08
Autor:
Apostolia-Maria Tsimberidou, Antonis Skliris, Alan Valentine, Jamie Shaw, Ursula Hering, Henry Hiep Vo, Tung On Chan, Roger S. Armen, Jeffrey R. Cottrell, Jen Q. Pan, Philip N. Tsichlis
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Background Changes in the expression and activity of the AKT oncogene play an important role in psychiatric disease. We present translational data assessing the role of AKT in psychiatric symptoms. Methods (1) We assessed the protein activit
Externí odkaz:
https://doaj.org/article/db571bc65b8444c39720d8f1d6ebe5cd
Autor:
Apostolia-Maria Tsimberidou, Jamie V. Shaw, Dejan Juric, Claire Verschraegen, Amy M. Weise, John Sarantopoulos, Gilberto Lopes, John Nemunaitis, Monica Mita, Haeseong Park, Barbara Ellers-Lenz, Hui Tian, Wenyuan Xiong, Remigiusz Kaleta, Razelle Kurzrock
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-10 (2021)
Abstract Background The PI3K/AKT/mTOR (PAM) pathway is a key regulator of tumor therapy resistance. We investigated M2698, an oral p70S6K/AKT dual inhibitor, in patients with advanced cancer who failed standard therapies. Methods M2698 was administer
Externí odkaz:
https://doaj.org/article/a4b6ff9c3cf54aeebe10a0ef9f20a8b8
Autor:
Apostolia-Maria Tsimberidou, Karlyle Van Morris, Henry Hiep Vo, Stephen Eck, Yu-Feng Lin, Jorge Mauricio Rivas, Borje S. Andersson
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-22 (2021)
Abstract T-cell receptor (TCR)-based adoptive therapy employs genetically modified lymphocytes that are directed against specific tumor markers. This therapeutic modality requires a structured and integrated process that involves patient screening (e
Externí odkaz:
https://doaj.org/article/dbd3c319b16c412d8746d232065b9d1a
Autor:
Apostolia-Maria Tsimberidou, David S. Hong, Jennifer J. Wheler, Gerald S. Falchook, Filip Janku, Aung Naing, Siqing Fu, Sarina Piha-Paul, Carrie Cartwright, Russell R. Broaddus, Graciela M. Nogueras Gonzalez, Patrick Hwu, Razelle Kurzrock
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-12 (2019)
Abstract Background In 2007, we initiated IMPACT, a precision medicine program for patients referred for participation in early-phase clinical trials. We assessed the correlation of factors, including genomically matched therapy, with overall surviva
Externí odkaz:
https://doaj.org/article/104ff192ed164bfea419fe086138f71a
Autor:
Harpreet Singh, Jason Luke, Mamta Kalra, Martin Wermke, Dejka Araujo, Ali Mohamed, Winfried Alsdorf, Apostolia-Maria Tsimberidou, Andrea Mayer-Mokler, Arun Satelli, Carsten Reinhardt, Dominik Maurer, George Jr Blumenschein, Kerstin Guenther, Manik Chatterjee, Norbert Hilf, Regina Mendrzyk, Steffen Walter, Stephen Eck, Tobias AW Holderried, Toni Weinschenk, Van Morris, Cedrik M Britten
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/bc94a9e9c64e462b8ba5414a6783526f
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Background: Patients with advanced and/or metastatic solid tumors have limited treatment options. Mutations that serve as biomarkers of carcinogenesis can be found in cell-free DNA of patients’ plasma. Analysis of circulating tumor DNA (ctDNA) was
Externí odkaz:
https://doaj.org/article/84efdbb2dfc64efc854dfa189b725138
Publikováno v:
Seminars in Cancer Biology. 84:284-292
Genomic profiling technologies have enabled the development of targeted therapies designed to target specific biomarkers and molecular pathways involved in the pathophysiology of tumor initiation, metastasis, and drug resistance. In recent years, cli
Autor:
Apostolia Maria Tsimberidou, Claire F. Verschraegen, Robert Wesolowski, Chi-Sheng Shia, Pei Hsu, Tillman E. Pearce
Publikováno v:
British Journal of Cancer.
Background Report of a Phase 1 dose-escalation study of OBI-3424 monotherapy in patients with advanced solid tumors (NCT03592264). Methods A classic 3 + 3 design was used to determine the maximum tolerated dose and recommended Phase 2 dose (RP2D) of