BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis

Autor: Logan Banadyga, Michael R. Knittler, Julia Holzerland, Julia E. Hölper, Allison Groseth, Lucie Fénéant

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 10, p e1008948 (2020)

Pathogenicity often differs dramatically among even closely related arenavirus species. For instance, Junín virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), is closely related to Tacaribe virus (TCRV), which is normally avirul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3f61cac50654c855cde2fe84f3dae6
http://europepmc.org/articles/PMC7598930

Retraction: Novel Insights into the Synergistic Interaction of a Thioredoxin Reductase Inhibitor and TRAIL: The Activation of the ASK1-ERK-Sp1 Pathway

Publikováno v: PLoS ONE

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces cell death in various types of cancer cells but has little or no effects on normal cells. Unfortunately, not all cancer cells respond to TRAIL; therefore, TRAIL sensitizing agent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4dd8f18fcf1702fa96bfbe04710e821e
https://pubmed.ncbi.nlm.nih.gov/23696862

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform

Autor: Michael Fichtner, Katherine McAllister, Christopher McCann, Jochen H. M. Prehn, Marc Sturrock, Daniel B. Longley, Anna Matveeva

Publikováno v: PLoS Computational Biology, Vol 15, Iss 9, p e1007374 (2019)
PLoS Computational Biology
Matveeva, A, Fichtner, M, McAllister, K, McCann, C, Sturrock, M, Longley, D B & Prehn, J H M 2019, ' Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform ', PLoS Computational Biology, vol. 15, no. 9, e1007374 . https://doi.org/10.1371/journal.pcbi.1007374

Ligand binding to death receptors activates apoptosis in cancer cells. Stimulation of death receptors results in the formation of intracellular multiprotein platforms that either activate the apoptotic initiator Caspase-8 to trigger cell death, or si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56392664045bd98e1cdeeeef8629cada
https://doaj.org/article/5d6098cfa19c4c0da6f939d03bc61d75

High rates of apoptosis visualized in the symbiont-bearing gills of deep-sea Bathymodiolus mussels

Autor: Ann C. Andersen, François H. Lallier, Sébastien Duperron, Bérénice Piquet, Bruce Shillito

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2019, 14 (2), pp.e0211499. ⟨10.1371/journal.pone.0211499⟩
PLoS ONE, 2019, 14 (2), pp.e0211499. ⟨10.1371/journal.pone.0211499⟩
Plos One (1932-6203) (Public Library Science), 2019-02, Vol. 14, N. 2, P. e0211499 (21p.)
PLoS ONE, Vol 14, Iss 2, p e0211499 (2019)

Symbiosis between Bathymodiolus and Gammaproteobacteria enables these deep-sea mussels to live in toxic environments like hydrothermal vents and cold seeps. The quantity of endosymbionts within the gill-bacteriocytes appears to vary according to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e68158966488189d48dadde1f5dd71b
https://hal.sorbonne-universite.fr/hal-02042415

Bcl-2-mediated control of TRAIL-induced apoptotic response in the non-small lung cancer cell line NCI-H460 is effective at late caspase processing steps

Autor: Danish, Lubna, Imig, Dirke, Allgöwer, Frank, Scheurich, Peter, Pollak, Nadine

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0198203 (2018)
PLoS ONE

Dysregulation of the mitochondrial signaling pathway of apoptosis induction represents a major hurdle in tumor therapy. The objective of the presented work was to investigate the role of the intrinsic (mitochondrial) apoptotic pathway in the non-smal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f68558f109bb484d53b189472d2fa5d