A locus conferring tolerance to Theileria infection in African cattle

Autor: Oswald Matika, Tatjana Sitt, Musa A. Hassan, Johanneke D. Hemmink, Elizabeth J. Poole, B.M. deC. Bronsvoort, Eaj Cook, Andrea Talenti, David Wragg, P. Latre de Late, Antoinette Aluoch Miyunga, W. I. Morrison, Phil Toye, James Prendergast, Timothy Connelley, Joseph E. Powell, Stephen Mwaura, M. Chepkowny, Rebecca Callaby, Gideon Ndambuki, Edith Paxton, Karen Marshall, Liam J. Morrison, R. Njeru, Harriet Auty

Publikováno v: Wragg, D, Cook, E A J, Latré de Laté, P, Sitt, T, Hemmink, H, Chepkowny, M, Njeru, M K, Poole, E J, Powell, J, Paxton, E, Callaby, R, Talenti, A, Miyunga, A A, Ndambuki, G, Mwaura, S, Auty, H, Matika, O, Hassan, M, Marshall, K, Connelley, T, Morrison, L, Bronsvoort, M, Morrison, I, Toye, P G & Prendergast, J 2022, ' A locus conferring tolerance to Theileria infection in African cattle ', PLoS Genetics, vol. 18, no. 4, e1010099 . https://doi.org/10.1371/journal.pgen.1010099

East Coast fever, a tick-borne cattle disease caused by theTheileria parvaparasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Boran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd94e9d88c46b4676539b3cac0b114a
https://doi.org/10.1371/journal.pgen.1010099

PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation

Autor: Seung-Hee Jo, Andrea Clocchiatti, G. Paolo Dotto, Dong-Eun Kim

Publikováno v: Oncotarget, vol. 7, no. 37, pp. 58717-58727
Oncotarget

// Seung-Hee Jo 1,2 , Dong Eun Kim 3 , Andrea Clocchiatti 1,2 and G. Paolo Dotto 1,3 1 Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA 2 Department of Dermatology, Harvard Medical School, Boston, MA, USA 3 Depa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea12f5aaed1cf56a0d17a8e7fc46ffdd
https://doi.org/10.18632/oncotarget.11227

Contribution of Intronic miR-338-3p and Its Hosting Gene AATK to Compensatory ß-Cell Mass Expansion

Autor: Fatima Bosch, Eduard Ayuso, Veronica Jimenez, Cécile Jacovetti, Marc Prentki, Romano Regazzi, Ross Laybutt, Marie-Line Peyot

Publikováno v: Molecular endocrinology (Baltimore Md.)
Molecular Endocrinology, vol. 29, no. 5, pp. 693-702

The elucidation of the mechanisms directing β-cell mass regeneration and maintenance is of interest, because the deficit of β-cell mass contributes to diabetes onset and progression. We previously found that the level of the microRNA (miRNA) miR-33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e6a95ac152f883055da7e02d51cd36
http://serval.unil.ch/?id=serval:BIB_912547987857

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

Autor: Carine Bonnard, Mohamed Denguezli, Ali Saad, François Malecaze, John E. Connolly, Seth L. Masters, Hazel Tye, Moez Gribaa, John A. McGrath, Kim S. Robinson, Ons Mamaï, Vincent Soler, Aristotle Lau, Reshmaa Balaji, Ildikó Szeverényi, Atsushi Otsuka, Masashi Akiyama, Pierre Fournié, Richard Hopkins, Keya Roy, Patricia J. Ahl, Sebastian Hiller, Lorenzo Sborgi, Lobna Boussofara, L. A. Jones, Roxana Ioana Nedelcu, Kenji Kabashima, Salma Samir Omar, Takuya Takeichi, E. Birgitte Lane, Franklin L. Zhong, Paul J. Baker, Bruno Reversade, Lukáš Lacina

Publikováno v: Cell
Cell, Elsevier, 2016, 167 (1), pp.187-202.e17. ⟨10.1016/j.cell.2016.09.001⟩
Cell, 167(1), 187-+. Cell Press
Cell, 2016, 167 (1), pp.187-202.e17. ⟨10.1016/j.cell.2016.09.001⟩

International audience; Inflammasome complexes function as key innate immune effectors that trigger inflammation in response to pathogen- and danger-associated signals. Here, we report that germline mutations in the inflammasome sensor NLRP1 cause tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4463444006fe6db979bfa8173593c7
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03158675

Epigenetic dysregulation of the death-associated protein kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma

Autor: Chi-Lung Choi, Raymond Liang, Chor Sang Chim, Tsz-Kin Fung, Yok-Lam Kwong

Publikováno v: Journal of Clinical Pathology. 60:664-669

Aim: To study the role of gene promoter hypermethylation of the putative tumour suppressor genes involved in the death-associated protein (DAP) kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma (MM). Method: DNAs from 55 primary MM mar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a654c2e14b27c52ac848d6635cae74eb
https://doi.org/10.1136/jcp.2006.038331