Výsledky vyhledávání - "Apoptosis/immunology"

Akademický článek

Apoptosis and in vivo models to study the molecules related to this phenomenon

Publikováno v: Einstein (São Paulo), Vol 8, Iss 4, Pp 495-497 (2010)

ABSTRACT Apoptosis or programmed cell death is a physiological process, essential for eliminating cells in excess or that are no longer necessary to the organism, acting on tissue homeostasis, although the phenomenon is also involved in pathological

Externí odkaz: https://doaj.org/article/a1dbf89563fe4f6a9644ff8d98b7bd2b

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CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Publikováno v: Nature immunology, vol. 21, no. 3, pp. 298-308
Nature Immunology, Vol. 21, No 3 (2020) pp. 298-308
Nature Immunology

Depleting regulatory T cells (T-reg cells) to counteract immunosuppressive features of the tumor microenvironment (TME) is an attractive strategy for cancer treatment; however, autoimmunity due to systemic impairment of their suppressive function lim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0890f7d204d5ad48cba3ed61051edb49
https://pubmed.ncbi.nlm.nih.gov/32066948

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Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity

Autor: Niek de Vries, Anja ten Brinke, Felix M. Wensveen, Niels A. W. Lemmermann, Erik Slinger, Eric Eldering, Doron Merkler, Inga Kavazović, Jan Koster, Hongya Han, Bojan Polić, Stipan Jonjić, Giulia Balzaretti, Yenan T. Bryceson, Paul L. Klarenbeek

Publikováno v: PLoS Biology
PLOS Biology, Vol. 18, No 3 (2020) P. e3000648
PLoS Biology, Vol 18, Iss 3, p e3000648 (2020)
PLoS biology, 18(3):e3000648. Public Library of Science
PLOS Biology
Volume 18
Issue 3

The memory CD8 T-cell pool must select for clones that bind immunodominant epitopes with high affinity to efficiently counter reinfection. At the same time, it must retain a level of clonal diversity to allow recognition of pathogens with mutated epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5afbb8abf6253d4434b39b4e66cf7be
https://pubmed.ncbi.nlm.nih.gov/32182234

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Comment on 'Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death'

Autor: Abdel Aouacheria, Ted Powers, J. Marie Hardwick, Zdena Palková, Kyle W. Cunningham, Fedor F. Severin, Libuše Váchová

Publikováno v: Science
Science, American Association for the Advancement of Science, 2018, 360 (6395), pp.eaar6910. ⟨10.1126/science.aar6910⟩
Science, 2018, 360 (6395), pp.eaar6910. ⟨10.1126/science.aar6910⟩

Shlezinger et al . (Reports, 8 September 2017, p. 1037) report that the common fungus Aspergillus fumigatus , a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fde7e2def3b8c1b4168c8f9a3ccc62
https://doi.org/10.1126/science.aar6910

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Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4? T cells

Autor: Hepworth, Matthew R, Fung, Thomas C, Masur, Samuel H, Kelsen, Judith R, McConnell, Fiona M, Dubrot Armendariz, Juan, Withers, David R, Hugues, Stéphanie, Farrar, Michael A, Reith, Walter, Eberl, Gérard, Baldassano, Robert N, Laufer, Terri M, Elson, Charles O, Sonnenberg, Gregory F

Publikováno v: Science (New York N.Y.)
Science, Vol. 348, No 6238 (2015) pp. 1031-1035

Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a7be6cd5e8a449f63d8e7709568737a3

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An essential protective role of IL-10 in the immunological mechanism underlying resistance vs susceptibility to lupus induction by dendritic cells and dying cells

Autor: HT Cook, Marina Botto, Guang Sheng Ling, Yu-Lung Lau, Fang-Ping Huang

Publikováno v: Rheumatology (Oxford, England)

Objective: To define the role of IL-10 in lupus pathogenesis, and to understand the immunological mechanisms underlying resistance vs susceptibility to lupus disease induction by dendritic cells (DCs) and dying cells. Methods: Groups of IL-10-deficie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d86c5da75d0a33bef509f362f819112
http://europepmc.org/articles/PMC3176714

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Histone Acetyltransferase Cofactor Trrap Is Essential for Maintaining the Hematopoietic Stem/Progenitor Cell Pool

Autor: Andreas Trumpp, Carla Sawan, Rabih Murr, Zhao-Qi Wang, Zdenko Herceg, Gabriela M. Oser, Joanna I. Loizou, Vivek Shukla

Publikováno v: Journal of Immunology, Vol. 183, No 10 (2009) pp. 6422-31

The pool of hematopoietic stem/progenitor cells, which provide life-long reconstitution of all hematopoietic lineages, is tightly controlled and regulated by self-renewal and apoptosis. Histone modifiers and chromatin states are believed to govern es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382c6d693083645a966552013f39b655
https://doi.org/10.4049/jimmunol.0901969

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Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus

Autor: Karl Tryggvason, Annika Scheynius, Shozo Izui, Fredrik Wermeling, Ola Winqvist, Yunying Chen, Mikael C. I. Karlsson, Timo Pikkarainen, Jeffrey V. Ravetch

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, Vol. 204, No 10 (2007) pp. 2259-2265

Apoptotic cells are considered to be a major source for autoantigens in autoimmune diseases such as systemic lupus erythematosus (SLE). In agreement with this, defective clearance of apoptotic cells has been shown to increase disease susceptibility.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5e2d43286fab503728990942ce3e1c
https://doi.org/10.1084/jem.20070600

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Influence of heat stress on human monocyte-derived dendritic cell functions with immunotherapeutic potential for antitumor vaccines

Autor: Pierre Formstecher, Thierry Velu, Audrey Lasek, Anne Sophie Hatzfeld-Charbonnier, Laurent Mortier, Laurent Castera, Philippe Gosset, Philippe Marchetti

Publikováno v: Journal of Leukocyte Biology
Journal of Leukocyte Biology, Society for Leukocyte Biology, 2007, 81 (5), pp.1179-1187. ⟨10.1189/jlb.0506347⟩
Journal of Leukocyte Biology, 2007, 81 (5), pp.1179-1187. ⟨10.1189/jlb.0506347⟩

Mild heat stress can modulate the activities of immune cells, including dendritic cells (DC) and theoretically, would constitute an innovative approach capable of enhancing the antitumor functions of DC. Therefore, we tested the effects of mild heat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801e0ec17255c9aa9e798911417a2ecf
https://doi.org/10.1189/jlb.0506347

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