Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Apoptosis/ drug effects"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol. 11, No 1 (2021) P. 18137
Scientific Reports
Scientific Reports, Vol. 11, No 1 (2021) P. 18137
Scientific Reports
Despite Paraquat (PQ) being banned in several countries, it is still one of the most commonly used herbicides in agriculture. This compound is known to induce damaging effects on human and animal brain cells by generating Reactive Oxygen Species (ROS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f726193cd36deafe615910a48ce44729
https://doaj.org/article/084e55285876488aafdac7ec4a55a5eb
https://doaj.org/article/084e55285876488aafdac7ec4a55a5eb
Autor:
Thomas L. Bonneaud, Chloé C. Lefebvre, Lisa Nocquet, Agnes Basseville, Julie Roul, Hugo Weber, Mario Campone, Philippe P. Juin, Frédérique Souazé
Publikováno v:
Cell Death and Disease
Cell Death and Disease, 2022, 13 (9), pp.787. ⟨10.1038/s41419-022-05214-9⟩
Cell Death and Disease, 2022, 13 (9), pp.787. ⟨10.1038/s41419-022-05214-9⟩
Cancer-associated fibroblasts (CAF) are a major cellular component of epithelial tumors. In breast cancers in particular these stromal cells have numerous tumorigenic effects in part due to their acquisition of a myofibroblastic phenotype. Breast CAF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6972279a29a9e26fdcde278f2df69c7
https://doi.org/10.1038/s41419-022-05214-9
https://doi.org/10.1038/s41419-022-05214-9
Autor:
Biancamaria Farina, Carsten Culmsee, Amalia Mihaela Dolga, Luigi Russo, Menotti Ruvo, Nunzianna Doti, Roberto Fattorusso, Fabiola Mascanzoni, Alessandra Monti, Andrea Caporale
Publikováno v:
Journal of Medicinal Chemistry, 64(15), 11445-11459. AMER CHEMICAL SOC
Blocking the interaction between the apoptosis-inducing factor (AIF) and cyclophilin A (CypA) by the AIF fragment AIF(370-394) is protective against glutamate-induced neuronal cell death and brain injury in mice. Starting from AIF(370-394), we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8753f90236e54cb76eea53ccd197d5e8
https://research.rug.nl/en/publications/04f3e107-9064-406a-8ac0-abfc6105b17f
https://research.rug.nl/en/publications/04f3e107-9064-406a-8ac0-abfc6105b17f
Autor:
Mas-Orea, Xavier, Sebert, Morgane, Benamar, Mehdi, Petitfils, Camille, Blanpied, Catherine, Saoudi, Abdelhadi, Deraison, Céline, Barreau, Frederick, Cenac, Nicolas, Dietrich, Gilles
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (14), 14 p. ⟨10.3390/ijms22147387⟩
International Journal of Molecular Sciences, 2021, 22 (14), pp.7387. ⟨10.3390/ijms22147387⟩
International Journal of Molecular Sciences, Vol 22, Iss 7387, p 7387 (2021)
Volume 22
Issue 14
International Journal of Molecular Sciences, MDPI, 2021, 22 (14), 14 p. ⟨10.3390/ijms22147387⟩
International Journal of Molecular Sciences, 2021, 22 (14), pp.7387. ⟨10.3390/ijms22147387⟩
International Journal of Molecular Sciences, Vol 22, Iss 7387, p 7387 (2021)
Volume 22
Issue 14
Mucosal CD4+ T lymphocytes display a potent opioid-mediated analgesic activity in interleukin (IL)-10 knockout mouse model of inflammatory bowel diseases (IBD). Considering that endogenous opioids may also exhibit anti-inflammatory activities in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bb134bb86675ea8d3653c20775f79e70
https://hal.inrae.fr/hal-03330200/document
https://hal.inrae.fr/hal-03330200/document
Autor:
Matteo Ferrari, Christian Krapp, Michela Muscolini, Angela Santoni, Martin R. Jakobsen, Alessandra Zevini, Alessandra Zingoni, David Olagnier, John Hiscott, Enrico Palermo, Giovanna Peruzzi, Luciano Castiello, Elisabetta Vulpis
Publikováno v:
Castiello, L, Zevini, A, Vulpis, E, Muscolini, M, Ferrari, M, Palermo, E, Peruzzi, G, Krapp, C, Jakobsen, M, Olagnier, D, Zingoni, A, Santoni, A & Hiscott, J 2019, ' An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation ', Cancer Immunology, Immunotherapy, vol. 68, no. 9, pp. 1479-1492 . https://doi.org/10.1007/s00262-019-02380-2
RIG-I is a cytosolic RNA sensor that recognizes short 5 ' triphosphate RNA, commonly generated during virus infection. Upon activation, RIG-I initiates antiviral immunity, and in some circumstances, induces cell death. Because of this dual capacity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a021b4cf5bcdbe0488874886620a2142
https://doi.org/10.1007/s00262-019-02380-2
https://doi.org/10.1007/s00262-019-02380-2
Autor:
William C. Cho, Vahideh Tarhriz, Kamran Hosseini, Parina Asgharian, Javad Sharifi-Rad, Saiedeh Razi Soofiyani, Haleh Forouhandeh, Željko Reiner, Tohid Ghasemnejad
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Lymphoma is a name for malignant diseases of the lymphatic system including Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Although several approaches are used for the treatment of these diseases, some of them are not successful and have serious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b91e03dab772a4ce7e253b92128d3c
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Antimitotic drugs arrest cells in mitosis through chronic activation of the spindle assembly checkpoint (SAC), leading to cell death. However, drug-treated cancer cells can escape death by undergoing mitotic slippage, due to premature mitotic exit. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65669c7d34d09c189b5e66595f1fe50
https://pubmed.ncbi.nlm.nih.gov/33603057
https://pubmed.ncbi.nlm.nih.gov/33603057
Autor:
Dan Ploug Christensen, Jakob Bondo Hansen, Thomas Mandrup-Poulsen, Seyed Mojtaba Ghiasi, Björn Tyrberg
Publikováno v:
International Journal of Molecular Sciences
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International journal of molecular sciences, vol. 21, no. 12 . https://doi.org/10.3390/ijms21124311
International Journal of Molecular Sciences, Vol 21, Iss 4311, p 4311 (2020)
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International Journal of Molecular Sciences (Online), vol. 21, no. 12, 4311 . https://doi.org/10.3390/ijms21124311
Volume 21
Issue 12
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International journal of molecular sciences, vol. 21, no. 12 . https://doi.org/10.3390/ijms21124311
International Journal of Molecular Sciences, Vol 21, Iss 4311, p 4311 (2020)
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International Journal of Molecular Sciences (Online), vol. 21, no. 12, 4311 . https://doi.org/10.3390/ijms21124311
Volume 21
Issue 12
Background: Intercellular communication mediated by cationic fluxes through the Connexin family of gap junctions regulates glucose-stimulated insulin secretion and beta cell defense against inflammatory stress. Rotigaptide (RG, ZP123) is a peptide an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6abcd30245c0405a97103ff0148386
http://europepmc.org/articles/PMC7352593
http://europepmc.org/articles/PMC7352593
Autor:
Cecilia Carubbi, Elena Masselli, Riccardo R.C. Bonadonna, Giuliana Gobbi, Anna Solini, Alessandra Dei Cas, Giulia Pozzi, Valentina Spigoni, Federica Fantuzzi
Publikováno v:
Cardiovascular Diabetology
Cardiovascular diabetology, 19 (1
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-15 (2020)
Cardiovascular diabetology, 19 (1
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-15 (2020)
The clear evidence of cardiovascular benefits in cardiovascular outcome trials of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in type 2 diabetes might suggest an effect on atherosclerotic plaque vulnerability and/or thrombosis, in which myeloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1d2ff06039e7052bef6fbb6960c97d
http://europepmc.org/articles/PMC7140327
http://europepmc.org/articles/PMC7140327
Autor:
Potočnjak, Iva
Osim antioksidacijskog djelovanja, fitokemikalije pokazuju i druge farmakološke učinke, uključujući modulaciju aktivacije različitih signalnih putova uključenih u oštećenje tkiva. Cisplatin (CP) je protutumorski lijek koji, pored željenog u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f3c9a779593e2061004ae80e96ed351a
https://www.bib.irb.hr/1054278
https://www.bib.irb.hr/1054278