Association of Triglyceride-Lowering LPL Variants and LDL-C–Lowering LDLR Variants With Risk of Coronary Heart Disease

Autor: Adam S. Butterworth, Deepak L. Bhatt, Alberico L. Catapano, Angela M. Wood, Chris J. Packard, Ulrich Laufs, Marc S. Sabatine, Stephen J. Nicholls, John J.P. Kastelein, Clare Oliver-Williams, John Danesh, Kausik K. Ray, Brian A. Ference, Henry N. Ginsberg, M. John Chapman, Emanuele Di Angelantonio

Publikováno v: JAMA, 321(4), 364-373. American Medical Association
Ference, B A, Kastelein, J J P, Ray, K K, Ginsberg, H N, Chapman, M J, Packard, C J, Laufs, U, Oliver-Williams, C, Wood, A M, Butterworth, A S, Di Angelantonio, E, Danesh, J, Nicholls, S J, Bhatt, D L, Sabatine, M S & Catapano, A L 2019, ' Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants with Risk of Coronary Heart Disease ', JAMA-Journal of the American Medical Association, vol. 321, no. 4, pp. 364-373 . https://doi.org/10.1001/jama.2018.20045

Importance: Triglycerides and cholesterol are both carried in plasma by apolipoprotein B (ApoB)-containing lipoprotein particles. It is unknown whether lowering plasma triglyceride levels reduces the risk of cardiovascular events to the same extent a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c250d644c00330364b70d0c9bb0eb94
https://europepmc.org/articles/PMC6439767/

Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice

Autor: Qizhi Wang, Chien-Ping Liang, Alan R. Tall, Marit Westerterp, Michihiro Matsumoto, Domenico Accili, Carrie L. Welch, Takafumi Senokuchi, Seongah Han

Publikováno v: The Journal of Clinical Investigation, 119(4), 1029-1041. AMER SOC CLINICAL INVESTIGATION INC

Type 2 diabetes is associated with accelerated atherogenesis, which may result from a combination of factors, including dyslipidemia characterized by increased VLDL secretion, and insulin resistance. To assess the hypothesis that both hepatic and per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d776dcc399c9bfef259d802f6374a4
https://doi.org/10.1172/jci36523

Increased Systemic and Plaque Inflammation in ABCA1 Mutation Carriers With Attenuation by Statins

Autor: Fleur M. van der Valk, Sonia Tolani, Erik S.G. Stroes, Andrea E. Bochem, Marit Westerterp, Alan R. Tall

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 35(7), 1663-1669. Lippincott Williams and Wilkins
Arteriosclerosis, thrombosis, and vascular biology, 35(7), 1663-1669. LIPPINCOTT WILLIAMS & WILKINS

Objective— We previously demonstrated that subjects with functional ATP-binding cassette ( ABC ) A1 mutations have increased atherosclerosis, which has been attributed to the role of ABCA1 in reverse cholesterol transport. More recently, a proinfla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e612adaab53664a8381c7d9454b09b07
https://pure.amc.nl/en/publications/increased-systemic-and-plaque-inflammation-in-abca1-mutation-carriers-with-attenuation-by-statins(a71535c6-35d8-40f6-a297-c10db913198f).html

Prospective associations between serum biomarkers of lipid metabolism and overall, breast and prostate cancer risk

Autor: Pilar Galan, Mathilde Touvier, Camille Pouchieu, Mathilde His, Mélanie Deschasaux, Serge Hercberg, Paule Latino-Martel, Jacques Blacher, Laurent Zelek, Emmanuelle Kesse-Guyot

Publikováno v: European Journal of Epidemiology
European Journal of Epidemiology, Springer Verlag, 2014, 29 (2), pp.119-132. ⟨10.1007/s10654-014-9884-5⟩

International audience; Experimental studies provided evidence about mechanisms by which cholesterol, especially high density lipoprotein cholesterol (HDL-C), could influence carcinogenesis, notably through antioxidant and anti-inflammatory propertie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76705224b7d147cc315524953bdf5251
https://hal.archives-ouvertes.fr/hal-02438528

An Immune Response Network Associated with Blood Lipid Levels

Autor: Michael Inouye, Gert-Jan B. van Ommen, Leena Peltonen, Samuli Ripatti, Pekka Jousilahti, Kennet Harald, Kaisa Silander, Satu Männistö, Johan G. Eriksson, Aarno Palotie, Markus Perola, Eija Hämäläinen, Veikko Salomaa, Janna Saarela, Marja-Riitta Taskinen, Emmanouil T. Dermitzakis

Publikováno v: PLoS Genetics
PLoS
PLOS Genetics, Vol. 6, No 9 (2010)
PLoS Genetics, Vol 6, Iss 9, p e1001113 (2010)
PLoS Genetics, 6(9)

While recent scans for genetic variation associated with human disease have been immensely successful in uncovering large numbers of loci, far fewer studies have focused on the underlying pathways of disease pathogenesis. Many loci which are associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deedf0a698aac361bacd2c7a68bac244
http://europepmc.org/articles/PMC2936545