Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Apolipoproteins A/genetics"'
Autor:
Belloy, Michael E, Eger, Sarah J, de Rojas, Itziar, Parveen, Kayenat, Sleegers, Kristel, Ingelsson, Martin, Hiltunen, Mikko, Amin, Najaf, Andreassen, Ole A, Sánchez-Juan, Pascual, Kehoe, Patrick Gavin, Amouyel, Philippe, Le Guen, Yann, Sims, Rebecca, Frikke-Schmidt, Ruth, van der Flier, Wiesje M, Lambert, Jean-Charles, BioBank, European Alzheimer & Dementia, He, Zihuai, Han, Summer S, Napolioni, Valerio, Greicius, Michael D, Damotte, Vincent, Ahmad, Shahzad, Ikram, M Arfan, Ramirez, Alfredo, Tsolaki, Anthoula C, Rossi, Giacomina, Jansen, Iris
Publikováno v:
Alzheimer's Research & Therapy, 14(1):22. BioMed Central
Alzheimer's Research & Therapy
Alzheimer's research & therapy
Belloy, M E, Eger, S J, Le Guen, Y, Damotte, V, Ahmad, S, Ikram, M A, Ramirez, A, Tsolaki, A C, Rossi, G, Jansen, I E, de Rojas, I, Parveen, K, Sleegers, K, Ingelsson, M, Hiltunen, M, Amin, N, Andreassen, O, Sánchez-Juan, P, Kehoe, P, Amouyel, P, Sims, R, Frikke-Schmidt, R, van der Flier, W M, Lambert, J C, He, Z, Han, S S, Napolioni, V, Greicius, M D & European Alzheimer & Dementia BioBank (EADB) 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's research & therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Belloy, M E, Eger, S J, le Guen, Y, Damotte, V, Ahmad, S, Ikram, M A, Ramirez, A, Tsolaki, A C, Rossi, G, Jansen, I E, de Rojas, I, Parveen, K, Sleegers, K, Ingelsson, M, Hiltunen, M, Amin, N, Andreassen, O, Sánchez-Juan, P, Kehoe, P, Amouyel, P, Sims, R, Frikke-Schmidt, R, van der Flier, W M, Lambert, J-C, He, Z, Han, S S, European Alzheimer & Dementia BioBank (EADB), Napolioni, V & Greicius, M D 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research & Therapy, vol. 14, no. 1, 22, pp. 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's research & therapy, 14(1):22. BioMed Central Ltd.
for the European Alzheimer & Dementia BioBank (EADB) 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research and Therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's research & therapy 14(1), 22 (2022). doi:10.1186/s13195-022-00962-4
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2022)
2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research & Therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's Research and Therapy, 14(1):22. BioMed Central
Alzheimer's Research & Therapy
Alzheimer's research & therapy
Belloy, M E, Eger, S J, Le Guen, Y, Damotte, V, Ahmad, S, Ikram, M A, Ramirez, A, Tsolaki, A C, Rossi, G, Jansen, I E, de Rojas, I, Parveen, K, Sleegers, K, Ingelsson, M, Hiltunen, M, Amin, N, Andreassen, O, Sánchez-Juan, P, Kehoe, P, Amouyel, P, Sims, R, Frikke-Schmidt, R, van der Flier, W M, Lambert, J C, He, Z, Han, S S, Napolioni, V, Greicius, M D & European Alzheimer & Dementia BioBank (EADB) 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's research & therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Belloy, M E, Eger, S J, le Guen, Y, Damotte, V, Ahmad, S, Ikram, M A, Ramirez, A, Tsolaki, A C, Rossi, G, Jansen, I E, de Rojas, I, Parveen, K, Sleegers, K, Ingelsson, M, Hiltunen, M, Amin, N, Andreassen, O, Sánchez-Juan, P, Kehoe, P, Amouyel, P, Sims, R, Frikke-Schmidt, R, van der Flier, W M, Lambert, J-C, He, Z, Han, S S, European Alzheimer & Dementia BioBank (EADB), Napolioni, V & Greicius, M D 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research & Therapy, vol. 14, no. 1, 22, pp. 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's research & therapy, 14(1):22. BioMed Central Ltd.
for the European Alzheimer & Dementia BioBank (EADB) 2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research and Therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's research & therapy 14(1), 22 (2022). doi:10.1186/s13195-022-00962-4
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2022)
2022, ' Challenges at the APOE locus : a robust quality control approach for accurate APOE genotyping ', Alzheimer's Research & Therapy, vol. 14, no. 1, 22 . https://doi.org/10.1186/s13195-022-00962-4
Alzheimer's Research and Therapy, 14(1):22. BioMed Central
Background Genetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE*2/3/4 genotypes. Identifying such variants and mechanisms would importantly advance our understanding of APOE pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a0c24c1a766cc73a83686215b99c5f
https://research.vumc.nl/en/publications/6828c379-3698-4b23-83ed-db73135922c1
https://research.vumc.nl/en/publications/6828c379-3698-4b23-83ed-db73135922c1
Autor:
Helgadottir, Anna, Thorleifsson, Gudmar, Snaebjarnarson, Audunn, Stefansdottir, Lilja, Sveinbjornsson, Gardar, Tragante, Vinicius, Björnsson, Eyþór, Steinthorsdottir, Valgerdur, Gretarsdottir, Solveig, Helgason, Hannes, Saemundsdottir, Jona, Olafsson, Isleifur, Thune, Jens Jakob, Axelsson Raja, Anna, Ghouse, Jonas, Olesen, Morten Salling, Christensen, Alex, Jacobsen, Rikke Louise, Dowsett, Joseph, Bruun, Mie Topholm, Nielsen, Kaspar, Knowlton, Kirk, Nadauld, Lincoln, Benediktsson, Rafn, Erikstrup, Christian, Pedersen, Ole B., Banasik, Karina, Brunak, Søren, Bundgaard, Henning, Ostrowski, Sisse R., Sulem, Patrick, Arnar, David O., Thorgeirsson, Gudmundur, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Stefansson, Kari, Holm, Hilma, Nyegaard, Mette
Publikováno v:
Helgadottir, A, Thorleifsson, G, Snaebjarnarson, A, Stefansdottir, L, Sveinbjornsson, G, Tragante, V, Björnsson, E, Steinthorsdottir, V, Gretarsdottir, S, Helgason, H, Saemundsdottir, J, Olafsson, I, Thune, J J, Axelsson Raja, A, Ghouse, J, Olesen, M S, Christensen, A, Jacobsen, R L, Dowsett, J, Bruun, M T, Nielsen, K, Knowlton, K, Nadauld, L, Benediktsson, R, Erikstrup, C, Pedersen, O B, Banasik, K, Brunak, S, Bundgaard, H, Ostrowski, S R, Sulem, P, Arnar, D O, Thorgeirsson, G, Thorsteinsdottir, U, Gudbjartsson, D F, Stefansson, K, Holm, H & DBDS Genomic Consortium 2022, ' Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles : A Mendelian randomization analysis ', European Journal of Preventive Cardiology, vol. 29, no. 18, pp. 2374-2385 . https://doi.org/10.1093/eurjpc/zwac219
Helgadottir, A, Thorleifsson, G, Snaebjarnarson, A, Stefansdottir, L, Sveinbjornsson, G, Tragante, V, Björnsson, E, Steinthorsdottir, V, Gretarsdottir, S, Helgason, H, Saemundsdottir, J, Olafsson, I, Thune, J J, Axelsson Raja, A, Ghouse, J, Olesen, M S, Christensen, A, Jacobsen, R L, Dowsett, J, Bruun, M T, Nielsen, K, Knowlton, K, Nadauld, L, Benediktsson, R, Erikstrup, C, Pedersen, O B, Banasik, K, Brunak, S, DBDS Genomic Consortium, Bundgaard, H, Ostrowski, S R, Sulem, P, Arnar, D O, Thorgeirsson, G, Thorsteinsdottir, U, Gudbjartsson, D F, Stefansson, K, Holm, H & Nyegaard, M 2022, ' Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles-A Mendelian randomization analysis ', European Journal of Preventive Cardiology, vol. 29, no. 18, zwac219, pp. 2374-2385 . https://doi.org/10.1093/eurjpc/zwac219
Helgadottir, A, Thorleifsson, G, Snaebjarnarson, A, Stefansdottir, L, Sveinbjornsson, G, Tragante, V, Björnsson, E, Steinthorsdottir, V, Gretarsdottir, S, Helgason, H, Saemundsdottir, J, Olafsson, I, Thune, J J, Axelsson Raja, A, Ghouse, J, Olesen, M S, Christensen, A, Jacobsen, R L, Dowsett, J, Bruun, M T, Nielsen, K, Knowlton, K, Nadauld, L, Benediktsson, R, Erikstrup, C, Pedersen, O B, Banasik, K, Brunak, S, Bundgaard, H, Ostrowski, S R, Sulem, P, Arnar, D O, Thorgeirsson, G, Thorsteinsdottir, U, Gudbjartsson, D F, Stefansson, K, Holm, H & DBDS Genomic Consortium 2022, ' Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles-A Mendelian randomization analysis ', European Journal of Preventive Cardiology, vol. 29, no. 18, pp. 2374–2385 . https://doi.org/10.1093/eurjpc/zwac219
Helgadottir, A, Thorleifsson, G, Snaebjarnarson, A, Stefansdottir, L, Sveinbjornsson, G, Tragante, V, Björnsson, E, Steinthorsdottir, V, Gretarsdottir, S, Helgason, H, Saemundsdottir, J, Olafsson, I, Thune, J J, Axelsson Raja, A, Ghouse, J, Olesen, M S, Christensen, A, Jacobsen, R L, Dowsett, J, Bruun, M T, Nielsen, K, Knowlton, K, Nadauld, L, Benediktsson, R, Erikstrup, C, Pedersen, O B, Banasik, K, Brunak, S, DBDS Genomic Consortium, Bundgaard, H, Ostrowski, S R, Sulem, P, Arnar, D O, Thorgeirsson, G, Thorsteinsdottir, U, Gudbjartsson, D F, Stefansson, K, Holm, H & Nyegaard, M 2022, ' Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles-A Mendelian randomization analysis ', European Journal of Preventive Cardiology, vol. 29, no. 18, zwac219, pp. 2374-2385 . https://doi.org/10.1093/eurjpc/zwac219
Helgadottir, A, Thorleifsson, G, Snaebjarnarson, A, Stefansdottir, L, Sveinbjornsson, G, Tragante, V, Björnsson, E, Steinthorsdottir, V, Gretarsdottir, S, Helgason, H, Saemundsdottir, J, Olafsson, I, Thune, J J, Axelsson Raja, A, Ghouse, J, Olesen, M S, Christensen, A, Jacobsen, R L, Dowsett, J, Bruun, M T, Nielsen, K, Knowlton, K, Nadauld, L, Benediktsson, R, Erikstrup, C, Pedersen, O B, Banasik, K, Brunak, S, Bundgaard, H, Ostrowski, S R, Sulem, P, Arnar, D O, Thorgeirsson, G, Thorsteinsdottir, U, Gudbjartsson, D F, Stefansson, K, Holm, H & DBDS Genomic Consortium 2022, ' Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles-A Mendelian randomization analysis ', European Journal of Preventive Cardiology, vol. 29, no. 18, pp. 2374–2385 . https://doi.org/10.1093/eurjpc/zwac219
Background and aims:The causal contribution of apolipoprotein B (apoB) particles to coronary artery disease (CAD) is established. We examined whether this atherogenic contribution is better reflected by non-high-density lipoprotein cholesterol (non-H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5f7c1eecea2efbebbb8764d66f63fd
https://pure.au.dk/portal/da/publications/cholesterol-not-particle-concentration-mediates-the-atherogenic-risk-conferred-by-apolipoprotein-b-particles(6ba7ddb1-b4a5-423c-9f98-107bd8082294).html
https://pure.au.dk/portal/da/publications/cholesterol-not-particle-concentration-mediates-the-atherogenic-risk-conferred-by-apolipoprotein-b-particles(6ba7ddb1-b4a5-423c-9f98-107bd8082294).html
Autor:
Tomassen, Jori, den Braber, Anouk, van der Lee, Sven J., Reus, Lianne M., Konijnenberg, Elles, Carter, Stephen F., Yaqub, Maqsood, van Berckel, Bart N.M., Collij, Lyduine E., Boomsma, Dorret I., de Geus, Eco J.C., Scheltens, Philip, Herholz, Karl, Tijms, Betty M., Visser, Pieter Jelle
Publikováno v:
BMC Neurology, 22(1):484. BioMed Central
BMC Neurology, 22(1):484. BioMed Central Ltd
Tomassen, J, den Braber, A, van der Lee, S J, Reus, L M, Konijnenberg, E, Carter, S F, Yaqub, M, van Berckel, B N M, Collij, L E, Boomsma, D I, de Geus, E J C, Scheltens, P, Herholz, K, Tijms, B M & Visser, P J 2022, ' Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer’s disease polygenic risk score ', BMC Neurology, vol. 22, no. 1, 484 . https://doi.org/10.1186/s12883-022-02925-6
BMC Neurology, 22(1):484. BioMed Central Ltd
Tomassen, J, den Braber, A, van der Lee, S J, Reus, L M, Konijnenberg, E, Carter, S F, Yaqub, M, van Berckel, B N M, Collij, L E, Boomsma, D I, de Geus, E J C, Scheltens, P, Herholz, K, Tijms, B M & Visser, P J 2022, ' Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer’s disease polygenic risk score ', BMC Neurology, vol. 22, no. 1, 484 . https://doi.org/10.1186/s12883-022-02925-6
Background: What combination of risk factors for Alzheimer’s disease (AD) are most predictive of cognitive decline in cognitively unimpaired individuals remains largely unclear. We studied associations between APOE genotype, AD-Polygenic Risk Score
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b192533d44bcbedde7a1c9c1ae8243
https://pubmed.ncbi.nlm.nih.gov/36522743
https://pubmed.ncbi.nlm.nih.gov/36522743
Publikováno v:
Alzheimer's Research & Therapy. 14(1)
BACKGROUND: Many families with clinical early-onset Alzheimer's disease (EOAD) remain genetically unexplained. A combination of genetic factors is not standardly investigated. In addition to monogenic causes, we evaluated the possible polygenic archi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::94e6520a02194573961fab0b4e6f27b0
https://doi.org/10.1186/s13195-022-01018-3
https://doi.org/10.1186/s13195-022-01018-3
Autor:
Mol, Merel O, van der Lee, Sven J, Hulsman, Marc, Pijnenburg, Yolande A L, Scheltens, Phillip, Seelaar, Harro, van Swieten, John C, Kaat, Laura Donker, Holstege, Henne, van Rooij, Jeroen G J
Publikováno v:
Alzheimer's Research & Therapy, 14(1). BioMed Central
BACKGROUND: Many families with clinical early-onset Alzheimer's disease (EOAD) remain genetically unexplained. A combination of genetic factors is not standardly investigated. In addition to monogenic causes, we evaluated the possible polygenic archi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::64aada2bcb467045ee00c94920f100ea
https://pure.knaw.nl/portal/en/publications/102fce40-6ae3-4c99-ae66-c238b09fd088
https://pure.knaw.nl/portal/en/publications/102fce40-6ae3-4c99-ae66-c238b09fd088
Autor:
Sabine Baumgartner, Anja Kerksiek, Ronald P. Mensink, Jogchum Plat, Dieter Lütjohann, Constanze Husche, Albert K. Groen
Publikováno v:
Journal of steroid biochemistry and molecular biology, 216:106039. PERGAMON-ELSEVIER SCIENCE LTD
Journal of Steroid Biochemistry and Molecular Biology, 216:106039. Elsevier Science
Journal of steroid biochemistry and molecular biology, 216:106039. Elsevier Limited
Journal of Steroid Biochemistry and Molecular Biology, 216:106039. Elsevier Science
Journal of steroid biochemistry and molecular biology, 216:106039. Elsevier Limited
We evaluated oxyphytosterol (OPS) concentrations in plasma and various tissues of two genetically modified mouse models with either increased cholesterol (apoE KO mice) or increased cholesterol and plant sterol (PS) concentrations (apoExABCG8 dKO mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e1918abc2b4c27d1fa518cb96dab28
http://www.scopus.com/inward/record.url?scp=85120897645&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85120897645&partnerID=8YFLogxK
Autor:
Cecilie R. Buskbjerg, S. M. Hadi Hosseini, Ali Amidi, Simon Buus, Robert Zachariae, Claus Højbjerg Gravholt
Publikováno v:
Buskbjerg, C R, Amidi, A, Buus, S, Gravholt, C H, Hadi Hosseini, S M & Zachariae, R 2022, ' Androgen deprivation therapy and cognitive decline-associations with brain connectomes, endocrine status, and risk genotypes ', Prostate Cancer and Prostatic Diseases, vol. 25, no. 2, pp. 208-218 . https://doi.org/10.1038/s41391-021-00398-1
BACKGROUND: Evidence suggests that prostate cancer (PC) patients undergoing androgen deprivation therapy (ADT) are at risk for cognitive decline (CD), but the underlying mechanisms are less clear. In the present study, changes in cognitive performanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de82d824a199d2bc90ac1aac63e4514
https://pure.au.dk/portal/da/publications/androgen-deprivation-therapy-and-cognitive-declineassociations-with-brain-connectomes-endocrine-status-and-risk-genotypes(f3034a45-54c4-4544-b8a0-54693c935228).html
https://pure.au.dk/portal/da/publications/androgen-deprivation-therapy-and-cognitive-declineassociations-with-brain-connectomes-endocrine-status-and-risk-genotypes(f3034a45-54c4-4544-b8a0-54693c935228).html
Publikováno v:
Saunders, T S, Jenkins, N, Blennow, K, Ritchie, C & Muniz-Terrera, G 2022, ' Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS) ', EBioMedicine, vol. 83, 104241 . https://doi.org/10.1016/j.ebiom.2022.104241
BACKGROUND: Alzheimer's Disease, the leading cause of dementia, is over-represented in females. The apolipoprotein E (APOE)ε4 allele is the strongest genetic risk factor for late-onset AD and is associated with aberrant cerebrospinal fluid levels (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a02117831259a9608c3c6b23734dcfb
https://doi.org/10.1016/j.ebiom.2022.104241
https://doi.org/10.1016/j.ebiom.2022.104241
Autor:
Federica Agosta, Stefania Orini, Flavio Nobili, Marina Boccardi, Cristina Festari, Alexander Drzezga, Javier Arbizu, Karl Herholz, Giovanni B. Frisoni, Peter J. Nestor, Zuzana Walker, Femke H. Bouwman, Daniele Altomare
Publikováno v:
European journal of nuclear medicine and molecular imaging 45(9), 1487-1496 (2018). doi:10.1007/s00259-018-4032-1
European Journal of Nuclear Medicine and Molecular Imaging, Vol. 45, No 9 (2018) pp. 1487-1496
EANM-EAN Task Force for the Prescription of FDG-PET for Dementing Neurodegenerative Disorders 2018, ' Diagnostic utility of 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) in asymptomatic subjects at increased risk for Alzheimer’s disease ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 45, no. 9, pp. 1487-1496 . https://doi.org/10.1007/s00259-018-4032-1
European Journal of Nuclear Medicine and Molecular Imaging, Vol. 45, No 9 (2018) pp. 1487-1496
EANM-EAN Task Force for the Prescription of FDG-PET for Dementing Neurodegenerative Disorders 2018, ' Diagnostic utility of 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) in asymptomatic subjects at increased risk for Alzheimer’s disease ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 45, no. 9, pp. 1487-1496 . https://doi.org/10.1007/s00259-018-4032-1
Purpose: To assess the clinical utility of 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) for detection of early signs of neurodegeneration in conditions of increased risk for Alzheimer’s disease (AD) as defined by: subjective cognit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c093ee8f8f89002a48f1f6aac265d96d
https://doi.org/10.1007/s00259-018-4032-1
https://doi.org/10.1007/s00259-018-4032-1
Publikováno v:
Nutrition Reviews
Nutrition Reviews, Oxford University Press (OUP), 2017, 75 (2), pp.134-145. ⟨10.1093/nutrit/nuw059⟩
Nutrition Reviews, 2017, 75 (2), pp.134-145. ⟨10.1093/nutrit/nuw059⟩
Nutrition Reviews, Oxford University Press (OUP), 2017, 75 (2), pp.134-145. ⟨10.1093/nutrit/nuw059⟩
Nutrition Reviews, 2017, 75 (2), pp.134-145. ⟨10.1093/nutrit/nuw059⟩
International audience; Low-density lipoprotein cholesterol (LDL-C) plays a causal role in atherosclerosis. One way to reduce LDL-C levels is to inhibit cholesterol absorption. Plant sterols and stanols compete with cholesterol for absorption in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7399a11f3b28041bb5609336f79bd336
https://doi.org/10.1093/nutrit/nuw059
https://doi.org/10.1093/nutrit/nuw059