Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Apolipoprotein Genes"'
Autor:
James R. Pancoast, Jennifer Hollister-Lock, Douglas A. Melton, Ahmed I. Mahmoud, Catherine MacGillivray, Francisco X Galdos, Richard T. Lee, Inbal Rachmin, Mark P. Jedrychowski, Gordon C. Weir, Steven P. Gygi, Samuel C. K. Lee, Ana Vujic, Katherine A Dinan, Jeffrey C. Davis, Christian Shigley
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204595 (2018)
PLoS ONE
PLoS ONE
The in vivo microenvironment of tissues provides myriad unique signals to cells. Thus, following isolation, many cell types change in culture, often preserving some but not all of their in vivo characteristics in culture. At least some of the in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f8a8528f5753c09b5ab65c97cc67d8
Autor:
Francesca Favaretto, Roberto Vettor, Marco Carraro, Anna Belligoli, Francesco Reggiani, Silvio C. E. Tosatto, Chiara Dal Pra, Carlo Ferrari, Marta Sanna
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0227191 (2020)
PLoS ONE
PLoS ONE
In this work we present a framework for blood cholesterol levels prediction from genotype data. The predictor is based on an algorithm for cholesterol metabolism simulation available in literature, implemented and optimized by our group in R language
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e71418fc82ab8c9f169072e09f51f7
http://hdl.handle.net/11577/3340188
http://hdl.handle.net/11577/3340188
Autor:
Luhua Qiao, Guangxiang George Luo
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 8, p e1007874 (2019)
PLoS Pathogens, Vol 15, Iss 8, p e1007874 (2019)
Hepatitis B virus (HBV) is a common cause of liver diseases, including chronic hepatitis, steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). HBV chronically infects about 240 million people worldwide, posing a major global health pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f524c6ef20575e2b88d0399ebeb826
http://europepmc.org/articles/PMC6687101
http://europepmc.org/articles/PMC6687101
Autor:
Sudha Seshadri, John Hardy, Wolfgang Maier, Janet C Harwood, Emily Baker, Carol Brayne, Julie Williams, Lesley Jones, Gerard D. Schellenberg, Reinhard Heun, Frank Jessen, Valentina Escott-Price, Matthew Hill, Oliver Peters, John Powell, Dobril Ivanov, Peter Passmore, Martin Dichgans, Lutz Frölich, Alfredo Ramirez, Aura Frizzati, Alison Goate, Kevin Morgan, Paul Morgan, Carlos Cruchaga, Ganna Leonenko, Gianfranco Spalletta, Paola Bossù, Michael Gill, Clive Holmes, Simon Mead, Detelina Grozeva, Peter Holmans, Philippe Amouyel, Rebecca Sims, Nicholas D. Allen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0218111 (2019)
PLOS ONE 14(7), e0218111 (2019). doi:10.1371/journal.pone.0218111
PLoS ONE, Vol 14, Iss 7, p e0218111 (2019)
PLOS ONE 14(7), e0218111 (2019). doi:10.1371/journal.pone.0218111
A novel POLARIS gene-based analysis approach was employed to compute gene-based polygenic risk score (PRS) for all individuals in the latest HRC imputed GERAD (N cases=3,332 and N controls=9,832) data using the International Genomics of Alzheimer’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caad960b1629d3f30b5bbfa303783204
http://europepmc.org/articles/PMC6613773
http://europepmc.org/articles/PMC6613773
Autor:
Aysegul Ekmekcioglu, Daniela T. Soltys, Ugur Sezerman, Asli Semerci, Nadja C. de Souza-Pinto, Meltem Muftuoglu, Mehmet Oguz Gok, Tugce Ertuzun, Mehmet Emin Cakir
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221362 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE
Base excision repair (BER) defects and concomitant oxidative DNA damage accumulation play a role in the etiology and progression of late-onset Alzheimer's disease (LOAD). However, it is not known whether genetic variant(s) of specific BER genes contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac6f2eb374172b24109c8ac82dafc93
https://doaj.org/article/a7561a199f124c228f6349c4fa4d47d8
https://doaj.org/article/a7561a199f124c228f6349c4fa4d47d8
Autor:
Lesley Leong, Steve Millard, Kaitlin Todd, Jessica Tulloch, Andrew Shutes-David, Martin Darvas, Brian C. Kraemer, Aleen D. Saxton, Eun Gyung Lee, Chang En Yu, C. Dirk Keene, Sunny Chen
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227667 (2020)
PLoS ONE
PLoS ONE
The apolipoprotein E gene (APOE) is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), yet the expression of APOE is not clearly understood. For example, it is unclear whether AD patients have elevated or decreased APOE expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7d80a0d7279791909386bb2ba4568b
https://doi.org/10.1371/journal.pone.0227667
https://doi.org/10.1371/journal.pone.0227667
Autor:
Qiong Yang, M. Arfan Ikram, Joshua C. Bis, Ramachandran S. Vasan, Lenore J. Launer, Nuno R. Zilhão, Tamara B. Harris, Bruce M. Psaty, Mary L. Biggs, Shuo Li, Daniel S. Evans, Frank J. Wolters, Vilmundur Gudnason, Sudha Seshadri, Mohsen Ghanbari, Johanna Jakobsdottir, Alexander M. Kulminski, Gregory J. Tranah
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0219668 (2019)
PLoS One (print), 14(7):e0219668. Public Library of Science
PLoS ONE, Vol 14, Iss 7, p e0219668 (2019)
PLoS One (print), 14(7):e0219668. Public Library of Science
BackgroundApolipoprotein E is a glycoprotein best known as a mediator and regulator of lipid transport and uptake. The APOE-ε4 allele has long been associated with increased risks of Alzheimer's disease and mortality, but the effect of the less prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d69f2f0c40b83ffb9d8e40b788b35d
https://pubmed.ncbi.nlm.nih.gov/31356640
https://pubmed.ncbi.nlm.nih.gov/31356640
Autor:
Alexander M. Kulminski, Amisha V. Barochia, Anatoliy I. Yashin, Konstantin G. Arbeev, Kaare Christensen, Mary K. Wojczynski, Bharat Thyagarajan, Nalini Raghavachari, Yury Loika, Badri N. Vardarajan, Stewart J. Levine
Publikováno v:
PLoS ONE
Kulminski, A M, Barochia, A V, Loika, Y, Raghavachari, N, Arbeev, K G, Wojczynski, M K, Thyagarajan, B, Vardarajan, B N, Christensen, K, Yashin, A I & Levine, S J 2018, ' The APOE ε4 allele is associated with a reduction in FEV1/FVC in women : A cross-sectional analysis of the long life family study ', PLOS ONE, vol. 13, no. 11, e0206873 . https://doi.org/10.1371/journal.pone.0206873
PLoS ONE, Vol 13, Iss 11, p e0206873 (2018)
Kulminski, A M, Barochia, A V, Loika, Y, Raghavachari, N, Arbeev, K G, Wojczynski, M K, Thyagarajan, B, Vardarajan, B N, Christensen, K, Yashin, A I & Levine, S J 2018, ' The APOE ε4 allele is associated with a reduction in FEV1/FVC in women : A cross-sectional analysis of the long life family study ', PLOS ONE, vol. 13, no. 11, e0206873 . https://doi.org/10.1371/journal.pone.0206873
PLoS ONE, Vol 13, Iss 11, p e0206873 (2018)
Introduction Murine studies have shown that apolipoprotein E modulates pulmonary function during development, aging, and allergen-induced airway disease. It is not known whether the polymorphic human APOE gene influences pulmonary function. Objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2618c45edcd1007c12850b34b42d4dc
https://pubmed.ncbi.nlm.nih.gov/30412599
https://pubmed.ncbi.nlm.nih.gov/30412599
Autor:
Grace Byfield, Farid Rajabli, Katrina Celis, Brian W. Kunkle, Jonathan L. Haines, Heriberto Acosta, Alejandra Rodriguez, Jeffery M. Vance, Vanessa C. Rodriguez, Kara L. Hamilton-Nelson, Goldie S. Byrd, Patrice L. Whitehead, Angel Chinea, Clara P. Manrique, Gary W. Beecham, Badri N. Vardarajan, Jacob L. McCauley, Margaret A. Pericak-Vance, Carolina B. Sierra Lopez, Gerard D. Schellenberg, Lindsay A. Farrer, Takiyah D. Starks, Parker Bussies, Michael L. Cuccaro, Eden R. Martin, Larry D. Adams, Briseida E. Feliciano, Christiane Reitz
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 12, p e1007791 (2018)
PLoS Genetics, Vol 14, Iss 12, p e1007791 (2018)
The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The risk conferred by ε4, however, differs across populations, with populations of African ancestry showing lower ε4 risk compared to those of Europea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c2024d0ea4f0433073ddea9b14414f
https://pubmed.ncbi.nlm.nih.gov/30517106
https://pubmed.ncbi.nlm.nih.gov/30517106
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 8, p e0201140 (2018)
PloS one, vol 13, iss 8
PLoS ONE, Vol 13, Iss 8, p e0201140 (2018)
PloS one, vol 13, iss 8
Case-control Genome-Wide Association Studies (GWAS) provide a rich resource for studying the genetic architecture of complex diseases. A key is to elucidate how the genetic effects vary by the environment, what is traditionally defined by Gene-Enviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e18a74b533d63b3832ee4b836de8f8
https://pubmed.ncbi.nlm.nih.gov/30133451
https://pubmed.ncbi.nlm.nih.gov/30133451