Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Apolipoprotein E ε4"'
Autor:
Xiaoli Yang, Yan Liu
Publikováno v:
Electronic Research Archive, Vol 32, Iss 1, Pp 1-16 (2024)
As is well known, the Apolipoprotein E (APOE) ε4 allele is the most pertinent genetic hazardous element for Alzheimer's disease (AD). Mild cognitive impairment (MCI) is considered a prodromal stage of AD. How the APOE ε4 allele modulates functional
Externí odkaz:
https://doaj.org/article/85a79b9fbe014eb0a26fa59d886067ba
Autor:
Louise N. Pivac, Belinda M. Brown, Kelsey R. Sewell, James D. Doecke, Victor L. Villemagne, Vincent Doré, Michael Weinborn, Hamid R. Sohrabi, Samantha L. Gardener, Romola S. Bucks, Simon M. Laws, Kevin Taddei, Paul Maruff, Colin L. Masters, Christopher Rowe, Ralph N. Martins, Stephanie R. Rainey‐Smith
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION This study investigated whether self‐reported sleep quality is associated with brain amyloid beta (Aβ) accumulation. METHODS Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (
Externí odkaz:
https://doaj.org/article/752e0f9b15914192953cf6940c065a99
Autor:
Hao Wang, Lin Shi, Shimei Luo, Yishan Luo, Chunyan Xu, Guozhen Qiu, Qiwen Guo, Chunchun Chen, Taikun Lu, Kangding Liu, Feiqi Zhu
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionThe ε4 allele of the apolipoprotein E gene (APOE4) is expressed abundantly in both the brain and peripheral circulation as a genetic risk factor for Alzheimer’s disease (AD). Cerebral blood flow (CBF) dysfunction is an essential featur
Externí odkaz:
https://doaj.org/article/03efc1a0e13c4c54bc84abc20211ea8a
Autor:
Nis Borbye‐Lorenzen, Yacila I. Deza‐Lougovski, Solveig Holmgaard, Luzia M. Weiss, Marie Bækvad‐Hansen, Kristin Skogstrand, Anna Rieckmann, Axel Börsch‐Supan, Martina Börsch‐Supan
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION The apolipoprotein E (APOE) ε4 allele is associated with high risk for Alzheimer's disease. It is unclear whether individual levels of the circulating apoE4 protein in ε4 carriers confer additional risk. Measuring apoE4 protei
Externí odkaz:
https://doaj.org/article/2160031580a64271b9a011fc6d14d47f
Autor:
Hyug‐Gi Kim, Yunan Tian, Sue Min Jung, Soonchan Park, Hak Young Rhee, Chang‐Woo Ryu, Geon‐Ho Jahng
Publikováno v:
Brain and Behavior, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Background Apolipoprotein E (ApoE) ε4 carriers have a higher risk of developing Alzheimer's disease (AD) and show brain atrophy and cognitive decline even before diagnosis. Objective To predict ApoE ε4 status using gray matter volume (GMV)
Externí odkaz:
https://doaj.org/article/c0ef4de38462425da6a69a0f1a13a2fc
Autor:
Bašić Jelena, Milošević Vuk, Đorđević Branka, Stefanović Nikola, Cvetković Marija, Jevtović-Stoimenov Tatjana, Stojanović Ivana
Publikováno v:
Archives of Biological Sciences, Vol 75, Iss 3, Pp 319-325 (2023)
Although single nucleotide polymorphisms rs429358 and rs7412 in the apolipoprotein E gene (APOE) are widely investigated to analyze APOE alleles, there are no data on their association with Alzheimer’s disease (AD) dementia in a Serbian population.
Externí odkaz:
https://doaj.org/article/4bb32cfb75fd40cfb1afab78634d4e31
Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status
Autor:
Maryam Ghahremani, Eric E. Smith, Hung‐Yu Chen, Byron Creese, Zahra Goodarzi, Zahinoor Ismail
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract Introduction Despite the association of vitamin D deficiency with incident dementia, the role of supplementation is unclear. We prospectively explored associations between vitamin D supplementation and incident dementia in 12,388 dementia‐
Externí odkaz:
https://doaj.org/article/133983d9e22e4d01b49555499a049cb5
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Cassandra C. Soo, Meagan T. Farrell, Stephen Tollman, Lisa Berkman, Almut Nebel, Michèle Ramsay
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/286cc16d662f4269bab6f65783b86292
Autor:
Bodil Weidung, Eva‐Stina Hemmingsson, Jan Olsson, Torbjörn Sundström, Kaj Blennow, Henrik Zetterberg, Martin Ingelsson, Fredrik Elgh, Hugo Lövheim
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Herpes simplex virus (HSV) may be involved in Alzheimer's disease (AD) pathophysiology. The antiviral valacyclovir inhibits HSV replication. Methods This phase‐II pilot trial involved valacyclovir administration (thrice daily,
Externí odkaz:
https://doaj.org/article/b5f15eb9bef14738b1679a567726d11e