Zobrazeno 1 - 10
of 774
pro vyhledávání: '"Apolipoprotein E (APOE)"'
Autor:
Hui Wang, Timothy S. Chang, Beth A. Dombroski, Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C. Van Swieten, Elise Dopper, Bernardino F. Ghetti, Kathy L. Newell, Claire Troakes, Justo G. de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G. Beach, Geidy E. Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A. Ross, Douglas Galasko, Adam L. Boxer, Bruce L. Miller, Willian W. Seeley, Vivanna M. Van Deerlin, Edward B. Lee, Charles L. White, Huw Morris, Rohan de Silva, John F. Crary, Alison M. Goate, Jeffrey S. Friedman, Yuk Yee Leung, Giovanni Coppola, Adam C. Naj, Li-San Wang, P. S. P. genetics study group, Clifton Dalgard, Dennis W. Dickson, Günter U. Höglinger, Gerard D. Schellenberg, Daniel H. Geschwind, Wan-Ping Lee
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. Previous genome-wide association studies for PSP w
Externí odkaz:
https://doaj.org/article/855cdef1a9b046af9ac1a7a118950c99
Autor:
Shilna Azhuvalappil, Raghav Prasad, Pravin Sahadevan, Priya Chatterjee, Hitesh Pradhan, Pooja Rai, Anant Gupta, Reddy Peera Kommaddi, Thomas G. Issac, Jonas S. Sundarakumar
Publikováno v:
Metabolism Open, Vol 23, Iss , Pp 100301- (2024)
Background: This study examines the association between apolipoprotein E (APOE) genotypes and metabolic syndrome (MetS) in an older urban population in South India, as part of the Tata Longitudinal Study on Aging. Methods: A total of 618 participants
Externí odkaz:
https://doaj.org/article/5398d9a8e1b146818707ab6e42ffb53e
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Human apolipoprotein E (ApoE) was first identified as a polymorphic gene in the 1970s; however, the genetic association of ApoE genotypes with late-onset sporadic Alzheimer’s disease (sAD) was only discovered 20 years later. Since then, intensive r
Externí odkaz:
https://doaj.org/article/483c99e64a824cccb8a3744b4a707193
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Fibroblast growth factor 21 (FGF21) is a peptide hormone that is primarily expressed and secreted by the liver. The hormone is crucial for regulation of glucose homeostasis, lipid metabolism, and energy balance. Compared with natural FGF21, FGF21 ana
Externí odkaz:
https://doaj.org/article/2315fd082b4149058ac1b9fdbaddff48
Autor:
Yulin Zhang, Ziwei Cheng, Liyu Hong, Jia Liu, Xinyue Ma, Wenjing Wang, Ran Pan, Wenjie Lu, Qichao Luo, Shan Gao, Qin Kong
Publikováno v:
Molecular Biomedicine, Vol 4, Iss 1, Pp 1-14 (2023)
Abstract Obesity is a metabolic disorder characterized by the hypertrophy expansion of adipose tissue, resulting in dysregulated energy metabolism, and accompanied by chronic low-grade inflammation. Adipose tissue macrophages (ATMs), a principal comp
Externí odkaz:
https://doaj.org/article/8d50385a51044303ae61f399a1cd42ed
Autor:
Aurore Nkiliza, Claire J.C. Huguenard, Gregory J. Aldrich, Scott Ferguson, Adam Cseresznye, Teresa Darcey, James E. Evans, Michael Dretsch, Michael Mullan, Fiona Crawford, Laila Abdullah
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 643-654 (2023)
Currently approved blood biomarkers detect intracranial lesions in adult patients with mild to moderate traumatic brain injury (TBI) acutely post-injury. However, blood biomarkers are still needed to help with a differential diagnosis of mild TBI (mT
Externí odkaz:
https://doaj.org/article/4d85eaf625a849fcbefcf0a7982e7839
Autor:
Vanessa Budny, Yannic Knöpfli, Debora Meier, Kathrin Zürcher, Chantal Bodenmann, Siri L. Peter, Terry Müller, Marie Tardy, Cedric Cortijo, Christian Tackenberg
Publikováno v:
Cells, Vol 13, Iss 14, p 1207 (2024)
The apolipoprotein E4 (APOE4) allele represents the major genetic risk factor for Alzheimer’s disease (AD). In contrast, APOE2 is known to lower the AD risk, while APOE3 is defined as risk neutral. APOE plays a prominent role in the bioenergetic ho
Externí odkaz:
https://doaj.org/article/baa10b6ded114f279653a3b6948e1156
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