ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein

Autor: Hanaa Mousa, Angelos Thanassoulas, Susu M. Zughaier

Publikováno v: Biochemistry and Biophysics Reports, Vol 34, Iss , Pp 101445- (2023)

Background: HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators’ release. It has been estimated that TLR4 recognizes a

Externí odkaz: https://doaj.org/article/2d72785d695e4f269141c5a422e41985

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Editorial: The Role of Sphingolipid Metabolism in the Development of Type 2 Diabetes and Obesity

Autor: Agnieszka Blachnio-Zabielska, Eric Hajduch, Hervé Le Stunff

Publikováno v: Frontiers in Endocrinology, Vol 12 (2022)

Externí odkaz: https://doaj.org/article/10c1a0cde8784f04a0c78aa1d12ae0b8

Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury

Autor: Zhen Guo, Carla Valenzuela Ripoll, Antonino Picataggi, David R. Rawnsley, Mualla Ozcan, Julio A. Chirinos, Ezhilarasi Chendamarai, Amanda Girardi, Terrence Riehl, Hosannah Evie, Ahmed Diab, Attila Kovacs, Krzysztof Hyrc, Xiucui Ma, Aarti Asnani, Swapnil V. Shewale, Marielle Scherrer-Crosbie, Lauren Ashley Cowart, John S. Parks, Lei Zhao, David Gordon, Francisco Ramirez-Valle, Kenneth B. Margulies, Thomas P. Cappola, Ankit A. Desai, Lauren N. Pederson, Carmen Bergom, Nathan O. Stitziel, Michael P. Rettig, John F. DiPersio, Stefan Hajny, Christina Christoffersen, Abhinav Diwan, Ali Javaheri

Publikováno v: JACC Basic Transl Sci
Guo, Z, Valenzuela Ripoll, C, Picataggi, A, Rawnsley, D R, Ozcan, M, Chirinos, J A, Chendamarai, E, Girardi, A, Riehl, T, Evie, H, Diab, A, Kovacs, A, Hyrc, K, Ma, X, Asnani, A, Shewale, S V, Scherrer-Crosbie, M, Cowart, L A, Parks, J S, Zhao, L, Gordon, D, Ramirez-Valle, F, Margulies, K B, Cappola, T P, Desai, A A, Pedersen, L N, Bergom, C, Stitziel, N O, Rettig, M P, DiPersio, J F, Hajny, S, Christoffersen, C, Diwan, A & Javaheri, A 2023, ' Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury ', JACC: Basic to Translational Science, vol. 8, no. 3, pp. 340-355 . https://doi.org/10.1016/j.jacbts.2022.09.010

ObjectivesDetermine the role of apolipoprotein M (ApoM) in anthracycline (Dox) cardiotoxicity.BackgroundApoM binds the cardioprotective sphingolipid sphingosine-1-phosphate (S1P). Circulating ApoM is inversely associated with mortality in human heart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0661923be6ea10183741312ef8961d2
https://doi.org/10.1016/j.jacbts.2022.09.010

Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis

Autor: Mette Mathiesen Janiurek, Rana Soylu-Kucharz, Christina Christoffersen, Krzysztof Kucharz, Martin Lauritzen

Publikováno v: eLife, Vol 8 (2019)

The blood-brain barrier (BBB) is formed by the endothelial cells lining cerebral microvessels, but how blood-borne signaling molecules influence permeability is incompletely understood. We here examined how the apolipoprotein M (apoM)-bound sphingosi

Externí odkaz: https://doaj.org/article/a69d746a561f43dab9ff992a894305d9