Zobrazeno 1 - 10
of 1 335
pro vyhledávání: '"ApoE −/− mice"'
Autor:
Xin Zhang, Jian-Li Ge, Kun Su, Jian-Ming He, Min-Mei Zhang, Jing Zhang, Yun-Long Ma, Yun-Chao Sun, Xin-Qiang Chu
Publikováno v:
World Journal of Traditional Chinese Medicine, Vol 10, Iss 3, Pp 363-369 (2024)
Objective: The objective of the study was to explore the regulatory mechanism of the Xiaozheng Tongluo method on lipid metabolism in liver tissue based on the sterol regulatory element-binding protein-2/(SREBP2)/3-hydroxy-3-methylglutaryl coenzyme A
Externí odkaz:
https://doaj.org/article/1c83edf64432443f96ac7a68fa142884
Publikováno v:
Guoji Yanke Zazhi, Vol 24, Iss 7, Pp 1027-1031 (2024)
AIM: To investigate the protective effect and mechanism of Danlou tablet on retinal ischemia-reperfusion injury(RIRI)in mice.METHODS: A total of 40 ApoE-/- mice were fed with high fat diet for 6 wk, and the RIRI model was established by anterior cham
Externí odkaz:
https://doaj.org/article/662693a730f9421e918ce9928c282e88
Publikováno v:
Zhongguo quanke yixue, Vol 27, Iss 05, Pp 557-562 (2024)
Background Atherosclerosis (AS) causes cardiovascular diseases such as myocardial infarction and myocardial fibrosis. Incidence of the population gradually increases with the aging of the global population. The inflammatory response is a key factor i
Externí odkaz:
https://doaj.org/article/e0e2be62f53e4cafb647e69f368e98a8
Autor:
Jing Luo, Ming Chen, Hongwu Ji, Jiayi Chen, Wenkui Song, Di Zhang, Weiming Su, Shucheng Liu, Julieth Joram Majura
Publikováno v:
Journal of Functional Foods, Vol 118, Iss , Pp 106280- (2024)
To explore the mechanism of carnosine in improving atherosclerosis, ApoE-/- mice fed a high-fat diet (HFD) were orally administered different doses of carnosine for 16 weeks. Carnosine intervention significantly reduced the arterial plaque area and e
Externí odkaz:
https://doaj.org/article/98a2a177a33446d794712051cbc588a1
Autor:
Li-Hui Meng, Shi-Yu Cheng, He Chen, Yue-Lin Wang, Wen-Fei Zhang, Huan Chen, Xin-Yu Zhao, You-Xin Chen
Publikováno v:
International Journal of Ophthalmology, Vol 17, Iss 1, Pp 16-24 (2024)
AIM: To investigate the impacts of angiotensin II (Ang II) on retinal artery changes in apolipoprotein E deficient (apoE -/-) mice. METHODS: ApoE -/- male mice were infused by minipumps with Ang II at 1000 ng/kg·min (Ang II group) or saline (control
Externí odkaz:
https://doaj.org/article/1f4db4069aca4172a3cf7d90e5e2fb0e
Autor:
Jianjie Rong, Chuanyong Li, Qiang Zhang, Guangfeng Zheng, Weijian Fan, Zhichang Pan, Shuming Shi
Publikováno v:
Pharmaceutical Biology, Vol 61, Iss 1, Pp 404-415 (2023)
AbstractContext Ferroptosis may play an essential role in lipid peroxidation and endothelial dysfunction of aortic endothelial cells (ECs) in type 2 diabetes mellitus (T2DM) with atherosclerosis (AS). Hydroxysafflor yellow A (HSYA) has shown substant
Externí odkaz:
https://doaj.org/article/b11451fede5b4e5eb8d82d271345b53a
Publikováno v:
Bioengineering, Vol 11, Iss 10, p 1033 (2024)
Atherosclerosis, as the main root cause, makes cardiovascular diseases (CVDs) a substantial worldwide health concern. Inflammation and disrupted cholesterol metabolism are the primary clinical risk elements contributing to the onset of atherosclerosi
Externí odkaz:
https://doaj.org/article/e5915f061b2c453988bfa0d1df084082
Publikováno v:
陆军军医大学学报, Vol 45, Iss 10, Pp 1010-1019 (2023)
Objective To explore the anti-atherogenic activity and mechanism involved of ginsenoside derivative CK201 by ApoE-/- mouse and human umbilical vein endothelial cells (HUVECs). Methods In vivo experiment: 6-week-old male ApoE-/- mice(n=30) were random
Externí odkaz:
https://doaj.org/article/794c7a867a6d4e95856ff71ebb623128
Autor:
Arianna Casciati, Emanuela Pasquali, Ilaria De Stefano, Ignacia Braga-Tanaka, Satoshi Tanaka, Mariateresa Mancuso, Francesca Antonelli, Simonetta Pazzaglia
Publikováno v:
Cells, Vol 13, Iss 11, p 899 (2024)
Apolipoprotein E (ApoE) is a lipid carrier in both the peripheral and the central nervous systems (CNSs). Lipid-loaded ApoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and brain injury repair. In the b
Externí odkaz:
https://doaj.org/article/09e729b4410240cc859a05d19e6b809d
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 643 (2024)
Atherosclerosis is the main pathological basis of cardiovascular diseases (CVDs). Fufang Danshen Tablet (FDT) is a traditional Chinese medicine that has been clinically used to treat CVDs for more than 40 years. Nevertheless, owing to the complexity
Externí odkaz:
https://doaj.org/article/ba7f17e38edc4c64835a209388971355