Zobrazeno 1 - 10
of 1 334
pro vyhledávání: '"ApoE−/− mice"'
Autor:
Xin Zhang, Jian-Li Ge, Kun Su, Jian-Ming He, Min-Mei Zhang, Jing Zhang, Yun-Long Ma, Yun-Chao Sun, Xin-Qiang Chu
Publikováno v:
World Journal of Traditional Chinese Medicine, Vol 10, Iss 3, Pp 363-369 (2024)
Objective: The objective of the study was to explore the regulatory mechanism of the Xiaozheng Tongluo method on lipid metabolism in liver tissue based on the sterol regulatory element-binding protein-2/(SREBP2)/3-hydroxy-3-methylglutaryl coenzyme A
Externí odkaz:
https://doaj.org/article/1c83edf64432443f96ac7a68fa142884
Publikováno v:
Guoji Yanke Zazhi, Vol 24, Iss 7, Pp 1027-1031 (2024)
AIM: To investigate the protective effect and mechanism of Danlou tablet on retinal ischemia-reperfusion injury(RIRI)in mice.METHODS: A total of 40 ApoE-/- mice were fed with high fat diet for 6 wk, and the RIRI model was established by anterior cham
Externí odkaz:
https://doaj.org/article/662693a730f9421e918ce9928c282e88
Autor:
Lu Liu, Jingjing Xu, Xiaochen Huang, Ying Wang, Xiaojun Ma, Xixiang Wang, Yu Liu, Xiuwen Ren, Jiahao Li, Yueyong Wang, Shaobo Zhou, Linhong Yuan
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117088- (2024)
Background: Changes in protein and lipid levels may occur in the Alzheimer’s disease brain, and DHA can have beneficial effects on it. To investigate the impact of DHA dietary intervention on brain protein and lipid profile in ApoE-/- mice and C57
Externí odkaz:
https://doaj.org/article/0adadd0cdbbb43178f35ea106bda896d
Publikováno v:
Zhongguo quanke yixue, Vol 27, Iss 05, Pp 557-562 (2024)
Background Atherosclerosis (AS) causes cardiovascular diseases such as myocardial infarction and myocardial fibrosis. Incidence of the population gradually increases with the aging of the global population. The inflammatory response is a key factor i
Externí odkaz:
https://doaj.org/article/e0e2be62f53e4cafb647e69f368e98a8
Autor:
Jing Luo, Ming Chen, Hongwu Ji, Jiayi Chen, Wenkui Song, Di Zhang, Weiming Su, Shucheng Liu, Julieth Joram Majura
Publikováno v:
Journal of Functional Foods, Vol 118, Iss , Pp 106280- (2024)
To explore the mechanism of carnosine in improving atherosclerosis, ApoE-/- mice fed a high-fat diet (HFD) were orally administered different doses of carnosine for 16 weeks. Carnosine intervention significantly reduced the arterial plaque area and e
Externí odkaz:
https://doaj.org/article/98a2a177a33446d794712051cbc588a1
Autor:
Li-Hui Meng, Shi-Yu Cheng, He Chen, Yue-Lin Wang, Wen-Fei Zhang, Huan Chen, Xin-Yu Zhao, You-Xin Chen
Publikováno v:
International Journal of Ophthalmology, Vol 17, Iss 1, Pp 16-24 (2024)
AIM: To investigate the impacts of angiotensin II (Ang II) on retinal artery changes in apolipoprotein E deficient (apoE -/-) mice. METHODS: ApoE -/- male mice were infused by minipumps with Ang II at 1000 ng/kg·min (Ang II group) or saline (control
Externí odkaz:
https://doaj.org/article/1f4db4069aca4172a3cf7d90e5e2fb0e
Autor:
Jianjie Rong, Chuanyong Li, Qiang Zhang, Guangfeng Zheng, Weijian Fan, Zhichang Pan, Shuming Shi
Publikováno v:
Pharmaceutical Biology, Vol 61, Iss 1, Pp 404-415 (2023)
AbstractContext Ferroptosis may play an essential role in lipid peroxidation and endothelial dysfunction of aortic endothelial cells (ECs) in type 2 diabetes mellitus (T2DM) with atherosclerosis (AS). Hydroxysafflor yellow A (HSYA) has shown substant
Externí odkaz:
https://doaj.org/article/b11451fede5b4e5eb8d82d271345b53a
Autor:
Xiao-Rong Lu, Qi Tao, Zhe Qin, Xi-Wang Liu, Shi-Hong Li, Li-Xia Bai, Wen-Bo Ge, Ya-Xian Liu, Jian-Yong Li, Ya-Jun Yang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116400- (2024)
Hyperlipidemia caused by abnormal lipid metabolism has reached epidemic proportions. This phenomenon is also common in companion animals. Previous studies showed that AEE significantly improves abnormal blood lipids in hyperlipidemia rats and mice, b
Externí odkaz:
https://doaj.org/article/6606594cd28340a797e33b1e6164e445
Autor:
Arianna Casciati, Emanuela Pasquali, Ilaria De Stefano, Ignacia Braga-Tanaka, Satoshi Tanaka, Mariateresa Mancuso, Francesca Antonelli, Simonetta Pazzaglia
Publikováno v:
Cells, Vol 13, Iss 11, p 899 (2024)
Apolipoprotein E (ApoE) is a lipid carrier in both the peripheral and the central nervous systems (CNSs). Lipid-loaded ApoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and brain injury repair. In the b
Externí odkaz:
https://doaj.org/article/09e729b4410240cc859a05d19e6b809d
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 643 (2024)
Atherosclerosis is the main pathological basis of cardiovascular diseases (CVDs). Fufang Danshen Tablet (FDT) is a traditional Chinese medicine that has been clinically used to treat CVDs for more than 40 years. Nevertheless, owing to the complexity
Externí odkaz:
https://doaj.org/article/ba7f17e38edc4c64835a209388971355