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Akademický článek

Therapeutic potential of Simvastatin in ALS: Enhanced axonal integrity and motor neuron survival through Apoa4 and Alb modulation

Autor: Song Luo, Xiaorui Wang, Bo Ma, Dongliang Liu, Li Li, Lijin Wang, Ning Ding, Liangyu Zou, Jie Wang, Jialin Pan, Daoqian Sang, Huadong Zhou, Hongdang Qu, Yi Lu, Lijuan Yang

Publikováno v: Biomolecules & Biomedicine (2024)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective death of motor neurons in the spinal cord, brainstem, and motor cortex. This study investigates the effects of simvastatin on the G93A-copper/zinc super

Externí odkaz: https://doaj.org/article/e65bcf1bf9f54400a645f70da5ade889

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Akademický článek

Single-cell RNA sequencing reveals a novel inhibitory effect of ApoA4 on NAFL mediated by liver-specific subsets of myeloid cells

Autor: Xiao-Huan Liu, Jin-Ting Zhou, Chun-xia Yan, Cheng Cheng, Jing-Na Fan, Jing Xu, Qiangsun Zheng, Qiang Bai, Zongfang Li, Shengbin Li, Xiaoming Li

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

The liver immune microenvironment is a key element in the development of hepatic inflammation in NAFLD. ApoA4 deficiency increases the hepatic lipid burden, insulin resistance, and metabolic inflammation. However, the effect of ApoA4 on liver immune

Externí odkaz: https://doaj.org/article/3748d6ce81e34f3dab0e2820ee8ca446

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Akademický článek

Quercetin Alleviates Inflammation and Energy Deficiency Induced by Lipopolysaccharide in Chicken Embryos

Autor: Jinhai Yu, Guoliang Hu, Xiaoquan Guo, Huabin Cao, Caiying Zhang

Publikováno v: Animals, Vol 13, Iss 13, p 2051 (2023)

Energy deficiency causes multiple organ dysfunctions after LPS induction. Quercetin is a phenolic compound found in herbal medicines. However, the effects of quercetin in alleviating LPS-induced energy deficiency remain unclear. In the present study,

Externí odkaz: https://doaj.org/article/956e527d9b9d4abb95f77ce27aa23372

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Akademický článek

Influence of genetic polymorphisms in homocysteine and lipid metabolism systems on antidepressant drug response

Autor: Baoyu Yuan, Xiaoyan Sun, Zhi Xu, Mengjia Pu, Yonggui Yuan, Zhijun Zhang

Publikováno v: BMC Psychiatry, Vol 20, Iss 1, Pp 1-9 (2020)

Abstract Background Variation in genes implicated in homocysteine and lipid metabolism systems may influence antidepressant response for patients with major depressive disorder (MDD). This study aimed to investigate whether association of polymorphis

Externí odkaz: https://doaj.org/article/e68aee2df1b64e2e8f717efcec9151d3

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Akademický článek

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Akademický článek

The Variants at APOA1 and APOA4 Contribute to the Susceptibility of Schizophrenia With Inhibiting mRNA Expression in Peripheral Blood Leukocytes

Autor: Yao Fan, Jun Gao, Yinghui Li, Xuefei Chen, Ting Zhang, Weiyan You, Yong Xue, Chong Shen

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

Objective: Abnormal lipid metabolism has a close link to the pathophysiology of schizophrenia (SZ). This study mainly aimed to evaluate the association of variants at apolipoprotein A1 (APOA1) and APOA4 with SZ in a Chinese Han population.Methods: Th

Externí odkaz: https://doaj.org/article/2d6ab865dd1b48bd83aff68a8f52e2ca

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