Zobrazeno 1 - 10
of 2 204
pro vyhledávání: '"Apicomplexan"'
Publikováno v:
mSphere, Vol 9, Iss 11 (2024)
ABSTRACT The Tyrosine Kinase-Like (TKL) family of proteins are a set of poorly studied kinases that have garnered attention in recent years for their role in Toxoplasma biology. The Toxoplasma genome contains eight TKL kinases, of which six have been
Externí odkaz:
https://doaj.org/article/7a5b5b0802364d5f9ddaf6beb6ce8913
Autor:
Avnish Patel, Aline Fréville, Joshua A. Rey, Helen R. Flynn, Konstantinos Koussis, Mark J. Skehel, Michael J. Blackman, David A. Baker
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT We previously reported that the Plasmodium falciparum putative serine/threonine protein phosphatase 7 (PP7) is a high-confidence substrate of the cAMP-dependent protein kinase (PKA). Here we explore the function of PP7 in asexual P. falcipar
Externí odkaz:
https://doaj.org/article/8e1daffe95784ff5ad6aba222b2a6941
Autor:
Rebecca R. Pasquarelli, Justin J. Quan, Emily S. Cheng, Vivian Yang, Timmie A. Britton, Jihui Sha, James A. Wohlschlegel, Peter J. Bradley
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT Toxoplasma gondii possesses a highly polarized secretory pathway that contains both broadly conserved eukaryotic organelles and unique apicomplexan organelles, which play essential roles in the parasite’s lytic cycle. As in other eukaryote
Externí odkaz:
https://doaj.org/article/bd70e26450dd4669976e1a1d2699ae14
Publikováno v:
Open Biology, Vol 14, Iss 11 (2024)
Toxoplasma gondii is an obligate intracellular parasite that can infect humans and diverse animals. Fatty acids are critical for the growth and proliferation of T. gondii, which has at least two pathways to synthesize fatty acids, including the type
Externí odkaz:
https://doaj.org/article/ad9817c9d81d4eb2a44fa12142ea6c80
Publikováno v:
mSphere, Vol 9, Iss 9 (2024)
ABSTRACT Expansion microscopy (ExM) is an innovative approach to achieve super-resolution images without using super-resolution microscopes, based on the physical expansion of the sample. The advent of ExM has unlocked the detail of super-resolution
Externí odkaz:
https://doaj.org/article/e6eb544e7ffe465f923706e5a6aace94
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Infection with the apicomplexan parasite Cryptosporidium is a leading cause of diarrheal disease. Cryptosporidiosis is of particular importance in infants and shows a strong association with malnutrition, both as a risk factor and as a conse
Externí odkaz:
https://doaj.org/article/9590de29d671445582465bc47250772a
Autor:
Diego Huet, Victoria Jeffers
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Intracellular infection by a pathogen induces significant rewiring of host cell signaling and biological processes. Understanding how an intracellular pathogen such as Toxoplasma gondii modulates host cell metabolism with single-cell resolut
Externí odkaz:
https://doaj.org/article/8cbc2eefcb20484392d2836642cdbcf0
Autor:
Sriveny Dangoudoubiyam, Jamie K. Norris, Sivaranjani Namasivayam, Rodrigo de Paula Baptista, Naila Cannes do Nascimento, Joseph Camp, Christopher L. Schardl, Jessica C. Kissinger, Daniel K. Howe
Publikováno v:
mSphere, Vol 9, Iss 6 (2024)
ABSTRACT Asexual replication in the apicomplexan Sarcocystis neurona involves two main developmental stages: the motile extracellular merozoite and the sessile intracellular schizont. Merozoites invade host cells and transform into schizonts that und
Externí odkaz:
https://doaj.org/article/4edbd293425b453f873a368b39735e63
Autor:
Bruno Martorelli Di Genova
Publikováno v:
mSphere, Vol 9, Iss 4 (2024)
ABSTRACTBruno Martorelli Di Genova works in parasitology, focusing on Toxoplasma gondii metabolism. In this mSphere of Influence article, he reflects on how the articles “Metabolic Reprogramming during Purine Stress in the Protozoan Pathogen Leishm
Externí odkaz:
https://doaj.org/article/f0fcf0e93f3f4f7083c26594910aaa2a