Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Aparna Vema"'
Autor:
Vera V. Grinkevich, Aparna Vema, Karin Fawkner, Natalia Issaeva, Virginia Andreotti, Eleanor R. Dickinson, Elisabeth Hedström, Clemens Spinnler, Alberto Inga, Lars-Gunnar Larsson, Anders Karlén, Margareta Wilhelm, Perdita E. Barran, Andrei L. Okorokov, Galina Selivanova, Joanna E. Zawacka-Pankau
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Restoration of the p53 tumor suppressor for personalised cancer therapy is a promising treatment strategy. However, several high-affinity MDM2 inhibitors have shown substantial side effects in clinical trials. Thus, elucidation of the molecular mecha
Externí odkaz:
https://doaj.org/article/6e3200658e124c519165fca58876e250
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 6, Pp 103863- (2022)
Histone deacetylases (HDACs) are key regulators of gene expression and have emerged as crucial therapeutic targets for cancer. Among the HDACs, inhibition of HDAC8 enzyme has been reported to be a novel strategy in the treatment of female-specific ca
Externí odkaz:
https://doaj.org/article/0f067d9869c04c0cbe95cdb173b846bb
Autor:
Aparna Vema, Arunasree M. Kalle
Publikováno v:
Computational Methods in Drug Discovery and Repurposing for Cancer Therapy ISBN: 9780443152801
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9714bd622a44a89bd914cf8e074e843b
https://doi.org/10.1016/b978-0-443-15280-1.00017-0
https://doi.org/10.1016/b978-0-443-15280-1.00017-0
Autor:
Vera V. Grinkevich, Aparna Vema, Karin Fawkner, Natalia Issaeva, Virginia Andreotti, Eleanor R. Dickinson, Elisabeth Hedström, Clemens Spinnler, Alberto Inga, Lars-Gunnar Larsson, Anders Karlén, Margareta Wilhelm, Perdita E. Barran, Andrei L. Okorokov, Galina Selivanova, Joanna E. Zawacka-Pankau
Restoration of the p53 tumor suppressor for personalised cancer therapy is a promising strategy. However, high-affinity MDM2 inhibitors have shown substantial side effects in clinical trials. Thus, elucidation of the molecular mechanisms of action of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc285934fd6328f7bd97b29f69441c5
https://doi.org/10.1101/2021.12.24.474003
https://doi.org/10.1101/2021.12.24.474003
Publikováno v:
Asian Journal of Chemistry. 31:1767-1773
A series of 21 O- and N-Mannich bases of 3,4-dihydropyrimidinones (2a-j and 3a-k) were synthesized by using microwave irradiation technique by multi-component reaction in two steps. All the compounds were evaluated for their free radical scavenging a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91bdfb6eddfba4a89b9fadec9bfeea7e
https://doi.org/10.14233/ajchem.2019.22008
https://doi.org/10.14233/ajchem.2019.22008
Publikováno v:
Bioorganic chemistry. 114
Two novel series of Dihydropyrimidine-hydroxamic acid hybrids (4a-4l and 5a-5l) were designed, synthesized and evaluated for in vitro Helicobacter pylori urease inhibition. In vitro enzyme inhibition screening led to the discovery of three potent ure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c19c2cc44021af639fa47809a89a94a
https://pubmed.ncbi.nlm.nih.gov/34102519
https://pubmed.ncbi.nlm.nih.gov/34102519
Autor:
Andrei L. Okorokov, Poroikov, C. Spinnler, Vera V. Grinkevich, Elisabeth Hedström, Perdita E. Barran, Joanna Zawacka-Pankau, Aparna Vema, Natalia Issaeva, Mikhail Burmakin, Alberto Inga, Eleanor R. Dickinson, Maria N. Preobrazhenskaya, Galina Selivanova, Olga Tarasova, S. N. Lavrenov, Fawkner K, Anders Karlén, Lars Larsson, Andreotti
Given the immense significance of p53 restoration for anti-cancer therapy and that p53-activating molecules are in clinical trials, elucidation of the mechanisms of action of p53-activating molecules is of the utmost importance. Here we report a disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075188e35e1d954df35a13045e3fc84a
Autor:
Galina Selivanova, S. N. Lavrenov, C. Spinnler, Vera V. Grinkevich, Natalia Issaeva, Alberto Inga, Margareta Wilhelm, Eleanor R. Dickinson, Karin Ridderstråle, Maria N. Preobrazhenskaya, Andrei L. Okorokov, Joanna Zawacka-Pankau, Olga Tarasova, Virginia Andreotti, Mikhail Burmakin, Perdita E. Barran, Aparna Vema, Anders Karlén, Elisabeth Hedström, Vladimir Poroikov, Lars-Gunnar Larsson
Publikováno v:
SSRN Electronic Journal.
Given the immense significance of p53 restoration for anti-cancer therapy, elucidation of the mechanisms of action of p53-activating molecules is of the utmost importance. Here we report a discovery of a novel allosteric modulation of p53 by small mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85e0de83907d5a6dce83b0ad1e044613
https://doi.org/10.2139/ssrn.3275278
https://doi.org/10.2139/ssrn.3275278
Akademický článek
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Autor:
Eva Åkerblom, Robert Rönn, Angelica E. Ehrenberg, Anja Sandström, Göran Dahl, Pernilla Örtqvist, Anders Karlén, U. Helena Danielson, Aparna Vema
Publikováno v:
Antiviral Therapy. 15:841-852
Background HCV infections are a serious threat to public health. An important drug target is the NS3 protease, for which several inhibitors are in clinical trials. Because of the high mutation rate of the virus, resistance against any HCV-specific dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59d7326deb9d09421b6313d55d6dc18
https://doi.org/10.3851/imp1655
https://doi.org/10.3851/imp1655