Výsledky vyhledávání - "Aparna V. Sarthy"

Data from Influence of Bcl-2 Family Members on the Cellular Response of Small-Cell Lung Cancer Cell Lines to ABT-737

Autor: Christin Tse, Saul H. Rosenberg, Steve W. Elmore, Stephen W. Fesik, Shi-Chung Ng, Robert B. Warner, Jun Chen, Aparna V. Sarthy, Susan E. Morgan-Lappe, Mark G. Anderson, Xiufen Yang, Stephen K. Tahir

ABT-737 is a novel and potent Bcl-2 antagonist with single-agent activity against small-cell lung cancer (SCLC) cell lines. Here, we evaluated the contribution of Bcl-2 family members to the in vitro cellular response of several SCLC cell lines to AB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886e68cc395eb08b7ca494cd35ebebce
https://doi.org/10.1158/0008-5472.c.6495347

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Species Specificity of Amidine-Based Urokinase Inhibitors

Autor: Richard S. Smith, Xumiao Zhao, Aparna V. Sarthy, Vicki L. Nienaber, Kent D. Stewart, Moshe Weitzberg, K. I. Hulkower, Christopher C Butler, Vered Klinghofer, Vincent L. Giranda, Todd W. Rockway, Paul G. Richardson, Sarah A. Dorwin, Michael D. Wendt, Tom Mcgonigal

Publikováno v: Biochemistry. 40:9125-9131

Inhibition of the proteolytic activity of urokinase has been shown to inhibit the progression of tumors in rodent models and is being investigated for use in human disease. Understanding the rodent/human species-specificity of urokinase inhibitors is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb2d632f905cfcfefc8eca0912cc0c5
https://doi.org/10.1021/bi010186u

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Antifungal rapamycin analogues with reduced immunosuppressive activity

Autor: Aparna V. Sarthy, Darlene J. Balli, James M. Trevillyan, L. Seif, Hong Ding, Robert C. Goldman, Morey L. Smith, Stephen J. Ballaron, Daniel A. Dickman, Ki H. Kim, Qun Li, Angela M. Nilius, Jacob J. Plattner, Youssef L. Bennani

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:1405-1408

Several 1,2,3,4-tetrahydro- and 7-N-hydroxycarbamate derivatives of the natural product rapamycin were prepared and assayed for their immunosuppressive and antifungal profiles. Substitutions at the 7-position indicate the possibility of a differentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcedd0ca3f58dba80109bd506c1b8d5
https://doi.org/10.1016/s0960-894x(00)00184-0

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Domain structure analysis of elongation factor-3 fromsaccharomyces cerevisiaeby limited proteolysis and differential scanning calorimetry

Autor: Robert C. Goldman, Seth W. Snyder, Tom Mcgonigal, Karl A. Walter, Uri S. Ladror, John O. Capobianco, Sarah A. Dorwin, Rohinton Edalji, David A. Egan, Thomas F. Holzman, Robert W. Johnson, Aparna V. Sarthy

Publikováno v: Protein Science. 7:2595-2601

Elongation-factor-3 (EF-3) is an essential factor of the fungal protein synthesis machinery. In this communication the structure of EF-3 from Saccharomyces cerevisiae is characterized by differential scanning calorimetry (DSC), ultracentrifugation, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7c059e34682363bfa73fa29b741180
https://doi.org/10.1002/pro.5560071213

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Identification and kinetic analysis of a functional homolog of elongation factor 3,YEF3 inSaccharomyces cerevisiae

Autor: Aparna V. Sarthy, Tom Mcgonigal, Robert C. Goldman, Charles M. Moehle, Simon R. Green, John O. Capobianco, Michael Schmidt

Publikováno v: Yeast. 14:239-253

Yeast and other fungi contain a soluble elongation factor 3 (EF-3) which is required for growth and protein synthesis. EF-3 contains two ABC cassettes, and binds and hydrolyses ATP. We identified a homolog of the YEF3 gene in the Saccharomyces cerevi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11655f26dc45b74fa210533d232b79e3
https://doi.org/10.1002/(sici)1097-0061(199802)14:3<239::aid-yea219>3.0.co

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Phenotype in Candida albicans of a disruption of the BGL2 gene encoding a 1,3-β-glucosyltransferase

Autor: Robert C. Goldman, Jonathan A. Meulbroek, Thomas McGonigal, Michael L. Coen, Aparna V. Sarthy, David Frost

Publikováno v: Microbiology. 143:367-376

The BGL2 gene encodes a unique 1,3-β-glucosyltransferase (BgI2p) present in the cell wall of Candida albicans and other fungi. Although believed to be involved in cell wall assembly, disruption of the gene in Saccharomyces cerevisiae showed no appar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa7b02fdf280b49002bff57278da179
https://doi.org/10.1099/00221287-143-2-367

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Identification of the gene encoding DNA topoisomerase I fromCandida albicans

Autor: Jennifer Fostel, Alison Taylor, Aparna V. Sarthy, Kellie Giles, Tom Mcgonigal

Publikováno v: FEMS Microbiology Letters. 138:113-121

A gene encoding a type I topoisomerase (TOP1) was isolated from Candida albicans, sequenced, and expressed in Saccharomyces cerevisiae. The TOP1 gene was identified from a C. albicans genomic library by hybridization with the product of a polymerase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953086dd08dcbf315cdfaed06b744421
https://doi.org/10.1111/j.1574-6968.1996.tb08143.x

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Cloning and sequence determination of the gene encoding sorbitol dehydrogenase from Saccharomyces cerevisiae

Autor: Kenneth B. Idler, Cynthia W. Schopp, Aparna V. Sarthy

Publikováno v: Gene. 140(1)

The identification of a sorbitol-induced sorbitol dehydrogenase (SDH) activity from Saccharomyces cerevisiae is described. The SDH1 structural gene was isolated from a λgt11 yeast genomic library using an antibody to a 40-kDa protein induced in yeas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d0940a776d439356482bf0fe9a7e04
https://pubmed.ncbi.nlm.nih.gov/8125328

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