Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Aparna Suvrathan"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract The amygdala nuclei modulate distributed neural circuits that most likely evolved to respond to environmental threats and opportunities. So far, the specific role of unique amygdala nuclei in the context processing of salient environmental c
Externí odkaz:
https://doaj.org/article/bd1ee842518043e0951a0edb5fdf8508
Autor:
Sriram Jayabal, Brandon J. Bhasin, Aparna Suvrathan, Jennifer DiSanto, Mark S. Goldman, Jennifer L. Raymond
A key function of the brain is to learn about the statistical relationships between events in the world. A mechanism of this learning is associative neural plasticity, controlled by the timing between neural events. Here, we show that experience can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9cb3b81698ed2b62bb1abe34f012517
https://doi.org/10.1101/2022.11.28.518128
https://doi.org/10.1101/2022.11.28.518128
Autor:
Aparna Suvrathan
Publikováno v:
Current Opinion in Neurobiology. 54:12-19
Synaptic plasticity, induced by the close temporal association of two neural signals, supports associative forms of learning. However, the millisecond timescales for association often do not match the much longer delays for behaviorally relevant sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712b62890b666acd3d3d5c16ac8c1350
https://doi.org/10.1016/j.conb.2018.06.011
https://doi.org/10.1016/j.conb.2018.06.011
Autor:
Aparna Suvrathan, Jennifer L. Raymond
Publikováno v:
The Cerebellum. 17:747-755
Climbing fiber-driven long-term depression (LTD) of parallel fiber synapses onto cerebellar Purkinje cells has long been investigated as a putative mechanism of motor learning. We recently discovered that the rules governing the induction of LTD at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f688298858394eeb5f9300afef8993
https://doi.org/10.1007/s12311-018-0968-8
https://doi.org/10.1007/s12311-018-0968-8
Autor:
Soroush Tahmasebi, Aparna Suvrathan, Vinh Tai Truong, Arkady Khoutorsky, Christos G. Gkogkas, Riya Elizabeth Thomas, Alanna J. Watt, Ilse Gantois, Patricia Roque, Mehdi Hooshmandi, Nahum Sonenberg, Vijendra Sharma, Masha Prager-Khoutorsky, Calvin Wong, Kleanthi Chalkiadaki, Eviatar Fields, Anindyo Chakraborty, Neil Wu
Publikováno v:
Cell Reports. 35:109036
Summary Recent studies have demonstrated that selective activation of mammalian target of rapamycin complex 1 (mTORC1) in the cerebellum by deletion of the mTORC1 upstream repressors TSC1 or phosphatase and tensin homolog (PTEN) in Purkinje cells (PC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5678cbe0debdf4bb694cd445907c1c0c
https://doi.org/10.1016/j.celrep.2021.109036
https://doi.org/10.1016/j.celrep.2021.109036
It is widely assumed that the complexity of neural circuits enables them to implement diverse learning tasks using just a few, generic forms of synaptic plasticity. In contrast, we report that synaptic plasticity can itself be precisely tuned to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f30910758d616de823f71bacfbaad6b
https://europepmc.org/articles/PMC5165237/
https://europepmc.org/articles/PMC5165237/
Publikováno v:
Stress. 13:533-540
Stress and depression may share common neural plasticity mechanisms. Importantly, the development and reversal of stress-induced plasticity requires time. These temporal aspects, however, are not captured fully in the forced-swim test (FST), a behavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09c5ea9eb6a1136654901d0413abc60
https://doi.org/10.3109/10253890.2010.489978
https://doi.org/10.3109/10253890.2010.489978
Publikováno v:
Proceedings of the National Academy of Sciences. 107:11591-11596
Fragile X syndrome (FXS), a common inherited form of mental impairment and autism, is caused by transcriptional silencing of the fragile X mental retardation 1 ( FMR1 ) gene. Earlier studies have identified a role for aberrant synaptic plasticity med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03040dd72ef2eb5b10b7c9d7b9d01ab2
https://doi.org/10.1073/pnas.1002262107
https://doi.org/10.1073/pnas.1002262107
Autor:
Sharath Bennur, Shobha Anilkumar, Sumantra Chattarji, Aparna Suvrathan, Anupratap Tomar, Supriya Ghosh
Publikováno v:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 369(1633)
Prolonged and severe stress leads to cognitive deficits, but facilitates emotional behaviour. Little is known about the synaptic basis for this contrast. Here, we report that in rats subjected to chronic immobilization stress, long-term potentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9c6802ee2ff3e48cceb13a24a2f64d
https://pubmed.ncbi.nlm.nih.gov/24298153
https://pubmed.ncbi.nlm.nih.gov/24298153
Autor:
Aparna Suvrathan, Sumantra Chattarji
Publikováno v:
Current opinion in neurobiology. 21(3)
Fragile X syndrome (FXS) is the most commonly inherited form of mental impairment and autism. Current understanding of the molecular and cellular mechanisms underlying FXS symptoms is derived mainly from studies on the hippocampus and cortex. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07776c20ff6b4c7808ae55074020dc7e
https://pubmed.ncbi.nlm.nih.gov/21555214
https://pubmed.ncbi.nlm.nih.gov/21555214