Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aparna Kareddula"'
Autor:
Aparna Kareddula, Daniel J. Medina, Whitney Petrosky, Sonia Dolfi, Irina Tereshchenko, Kelly Walton, Hana Aviv, Evita Sadimin, Alexandra L. Tabakin, Eric A. Singer, Kim M. Hirshfield
Publikováno v:
Therapeutic Advances in Urology, Vol 13 (2021)
Background: Prostate cancer (PCa) phenotypes vary from indolent to aggressive. Molecular subtyping may be useful in predicting aggressive cancers and directing therapy. One such subtype involving deletions of chromodomain helicase DNA binding protein
Externí odkaz:
https://doaj.org/article/ca950f5f2b464ee8b0c531557af922af
Autor:
Mark N. Stein, Jyoti Malhotra, Rohinton S. Tarapore, Usha Malhotra, Ann W. Silk, Nancy Chan, Lorna Rodriguez, Joseph Aisner, Robert D. Aiken, Tina Mayer, Bruce G. Haffty, Jenna H. Newman, Salvatore M. Aspromonte, Praveen K. Bommareddy, Ricardo Estupinian, Charles B. Chesson, Evita T. Sadimin, Shengguo Li, Daniel J. Medina, Tracie Saunders, Melissa Frankel, Aparna Kareddula, Sherrie Damare, Elayne Wesolowsky, Christian Gabel, Wafik S. El-Deiry, Varun V. Prabhu, Joshua E. Allen, Martin Stogniew, Wolfgang Oster, Joseph R. Bertino, Steven K. Libutti, Janice M. Mehnert, Andrew Zloza
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Background ONC201 is a small molecule antagonist of DRD2, a G protein-coupled receptor overexpressed in several malignancies, that has prolonged antitumor efficacy and immunomodulatory properties in preclinical models. The first-in-human tri
Externí odkaz:
https://doaj.org/article/cc2e3e6b70b34104941a2588a1bfa557
Autor:
Kelly Walton, Sonia C. Dolfi, Aparna Kareddula, Eric A. Singer, Hana Aviv, Evita Sadimin, Irina V. Tereshchenko, Kim M Hirshfield, Daniel J. Medina, Whitney Petrosky, Alexandra L. Tabakin
Publikováno v:
Therapeutic Advances in Urology, Vol 13 (2021)
Therapeutic Advances in Urology
Therapeutic Advances in Urology
Background: Prostate cancer (PCa) phenotypes vary from indolent to aggressive. Molecular subtyping may be useful in predicting aggressive cancers and directing therapy. One such subtype involving deletions of chromodomain helicase DNA binding protein
Autor:
Praveen K. Bommareddy, Wafik S. El-Deiry, Tracie Saunders, Salvatore M. Aspromonte, Lorna Rodriguez, Rohinton Tarapore, Janice M. Mehnert, Steven K. Libutti, Nancy Chan, Ann W. Silk, Jenna H. Newman, Charles B. Chesson, Elayne Wesolowsky, Daniel J. Medina, Christian Gabel, Martin Stogniew, Shengguo Li, Joseph R. Bertino, Joshua E. Allen, Mark N. Stein, Evita Sadimin, Aparna Kareddula, Joseph Aisner, Sherrie Damare, Jyoti Malhotra, Wolfgang Oster, Varun V. Prabhu, Bruce G. Haffty, Andrew Zloza, Ricardo Estupinian, Tina M. Mayer, Melissa Frankel, Robert Aiken, Usha Malhotra
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Background ONC201 is a small molecule antagonist of DRD2, a G protein-coupled receptor overexpressed in several malignancies, that has prolonged antitumor efficacy and immunomodulatory properties in preclinical models. The first-in-human trial of ONC
Autor:
Sonia C. Dolfi, Aparna Kareddula, Suzie Chen, Kim M. Hirshfield, Alexei Vazquez, Bhavna S. Paratala, Ashley Rose, Jatinder Dhami, Shridar Ganesan, Gillian M. Mackay, Daniel J. Medina
Publikováno v:
Oncotarget
Recent evidence suggests that glutamate signaling plays an important role in cancer. Riluzole is a glutamate release inhibitor and FDA-approved drug for the treatment of amyotrophic lateral sclerosis. It has been investigated as an inhibitor of cance
Autor:
Michael Reiss, Hilde H. Nienhuis, Whitney Banach-Petrosky, Vidya Ganapathy, Gregory D. Miles, Aparna Kareddula, Wen Xie
Publikováno v:
Clinical & Experimental Metastasis, 29(5), 493-509. SPRINGER
Luminal breast cancer is the most frequently encountered type of human breast cancer and accounts for half of all breast cancer deaths due to metastatic disease. We have developed new in vivo models of disseminated human luminal breast cancer that cl
Autor:
Nancy Chan, Lorna Rodriguez-Rodriguez, Robert Aiken, Jyoti Malhotra, Usha Malhotra, Aparna Kareddula, Joseph Aisner, Tracie Saunders, Janice M. Mehnert, Evita Sadimin, Andrew Zloza, Jenna H. Newman, Steven K. Libutti, Wafik S. El-Deiry, Melissa Frankel, Joseph R. Bertino, Joshua E. Allen, Mark N. Stein, Rohinton Tarapore, Ann W. Silk
Publikováno v:
Journal of Clinical Oncology. 36:2595-2595
2595Background: ONC201 is a small molecule antagonist of DRD2, a G protein-coupled receptor overexpressed in several malignancies, that has prolonged antitumor efficacy in preclinical cancer models...
Autor:
Irina V. Tereshchenko, Kim M. Hirshfield, Hana Aviv, Daniel Medina, Aparna Kareddula, Eric Singer, Robert S. DiPaola, Whitney Petrosky
Publikováno v:
Cancer Research. 77:5883-5883
Prostate cancer (PCa) develops into lethal disease in about 10% of men diagnosed with this malignancy. Common genomic changes are seen in PCa such as alterations in CDKN1B, RB1, TP53, PTEN, NKX3-1, MYC and androgen receptor. Oncogenic fusions involvi