Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Aparna H Kesarwala"'
Autor:
Caroline S. Jansen, Meghana S. Pagadala, Maria A. Cardenas, Roshan S. Prabhu, Subir Goyal, Chengjing Zhou, Prasanthi Chappa, BaoHan T. Vo, Chengyu Ye, Benjamin Hopkins, Jim Zhong, Adam Klie, Taylor Daniels, Maedot Admassu, India Green, Neil T. Pfister, Stewart G. Neill, Jeffrey M. Switchenko, Nataliya Prokhnevska, Kimberly B. Hoang, Mylin A. Torres, Suzanna Logan, Jeffrey J. Olson, Edjah K. Nduom, Luke del Balzo, Kirtesh Patel, Stuart H. Burri, Anthony L. Asher, Scott Wilkinson, Ross Lake, Aparna H. Kesarwala, Kristin A. Higgins, Pretesh Patel, Vishal Dhere, Adam G. Sowalsky, Hannah Carter, Mohammad K. Khan, Haydn Kissick, Zachary S. Buchwald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Enhancing the efficacy of immunotherapy in brain metastases (BrM) requires an improved understanding of the immune composition of BrM and how this is affected by radiation and dexamethasone. Our two-arm pilot study (NCT04895592) allocated 26
Externí odkaz:
https://doaj.org/article/f2e15d60d8c7479ea6d0d2f87a5326a2
Autor:
Zafer Gurel, Michael S. Luy, Qianyun Luo, Nicholas L. Arp, Amy K. Erbe, Aparna H. Kesarwala, Jing Fan, Randall J. Kimple
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionLactate is a pivotal molecule with diverse functions in the metabolic reprogramming of cancer cells. Beyond its role in metabolism, lactate exerts a modulatory effect within the tumor microenvironment; it is utilized by stromal cells and
Externí odkaz:
https://doaj.org/article/e11c06729ad144b8b224cd5c1aa245f1
Autor:
Yoichi Takakusagi, Shingo Matsumoto, Keita Saito, Masayuki Matsuo, Shun Kishimoto, Jonathan W Wojtkowiak, William DeGraff, Aparna H Kesarwala, Rajani Choudhuri, Nallathamby Devasahayam, Sankaran Subramanian, Jeeva P Munasinghe, Robert J Gillies, James B Mitchell, Charles P Hart, Murali C Krishna
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107995 (2014)
TH-302 is a hypoxia-activated prodrug (HAP) of bromo isophosphoramide mustard that is selectively activated within hypoxic regions in solid tumors. Our recent study showed that intravenously administered bolus pyruvate can transiently induce hypoxia
Externí odkaz:
https://doaj.org/article/0938aa4f3d55486b8f95bb9b28022c2c
Autor:
James R. Janopaul-Naylor, Yichun Cao, Neal S. McCall, Jeffrey M. Switchenko, Sibo Tian, Haijian Chen, William A. Stokes, Aparna H. Kesarwala, Mark W. McDonald, Joseph W. Shelton, Jeffrey D. Bradley, Kristin A. Higgins
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
IntroductionAs immunotherapy has improved distant metastasis-free survival (DMFS) in Non-Small Cell Lung Cancer (NSCLC), isolated locoregional recurrences have increased. However, management of locoregional recurrences can be challenging. We report o
Externí odkaz:
https://doaj.org/article/d091abf36c46469abda19b81c829b0db
Autor:
Aizea Morales-Kastresana, Thomas A. Musich, Joshua A. Welsh, William Telford, Thorsten Demberg, James C. S. Wood, Marty Bigos, Carley D. Ross, Aliaksander Kachynski, Alan Dean, Edward J. Felton, Jonathan Van Dyke, John Tigges, Vasilis Toxavidis, David R. Parks, W. Roy Overton, Aparna H. Kesarwala, Gordon J. Freeman, Ariel Rosner, Stephen P. Perfetto, Lise Pasquet, Masaki Terabe, Katherine McKinnon, Veena Kapoor, Jane B. Trepel, Anu Puri, Hisataka Kobayashi, Bryant Yung, Xiaoyuan Chen, Peter Guion, Peter Choyke, Susan J. Knox, Ionita Ghiran, Marjorie Robert-Guroff, Jay A. Berzofsky, Jennifer C. Jones
Publikováno v:
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
Biological nanoparticles, including viruses and extracellular vesicles (EVs), are of interest to many fields of medicine as biomarkers and mediators of or treatments for disease. However, exosomes and small viruses fall below the detection limits of
Externí odkaz:
https://doaj.org/article/35b24a5cb7a045568c0b5774e0dc12d8
Autor:
Nolan E. Hertel, Steven R. Biegalski, Victoria I. Nelson, William A. Nelson, Sharmistha Mukhopadhyay, Zitong Su, Alexis M. Chan, Aparna H. Kesarwala, William S. Dynan
Publikováno v:
Life Sciences in Space Research. 35:163-169
Implementation of a systematic program for galactic cosmic radiation (GCR) countermeasure discovery will require convenient access to ground-based space radiation analogs. The current gold standard approach for GCR simulation is to use a particle acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f24c31eab0be5b5ed372212876dfb8
https://doi.org/10.1016/j.lssr.2022.10.002
https://doi.org/10.1016/j.lssr.2022.10.002
Autor:
Yang, Lei, Tonghe, Wang, Jiwoong J, Jeong, James, Janopaul-Naylor, Aparna H, Kesarwala, Justin, Roper, Sibo, Tian, Jeffrey D, Bradley, Tian, Liu, Kristin, Higgins, Xiaofeng, Yang
Publikováno v:
Medical Physics. 50:274-283
Multimodality positron emission tomography/computed tomography (PET/CT) imaging combines the anatomical information of CT with the functional information of PET. In the diagnosis and treatment of many cancers, such as non-small cell lung cancer (NSCL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0ad0de2ae7b40438f7143a51e914d7
https://doi.org/10.1002/mp.16001
https://doi.org/10.1002/mp.16001
Autor:
Neal S. McCall, Hamilton S. McGinnis, James R. Janopaul-Naylor, Aparna H. Kesarwala, Sibo Tian, William A. Stokes, Joseph W. Shelton, Conor E. Steuer, Jennifer W. Carlisle, Ticiana Leal, Suresh S. Ramalingam, Jeffrey D. Bradley, Kristin A. Higgins
Publikováno v:
Radiotherapy and Oncology. 174:133-140
Higher estimated radiation doses to immune cells (EDIC) have correlated with worse overall survival (OS) in patients with locally-advanced non-small cell lung cancer (NSCLC) prior to the PACIFIC trial, which established consolidative durvalumab as st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a32211184d7930da6bea87a9068085
https://doi.org/10.1016/j.radonc.2022.07.015
https://doi.org/10.1016/j.radonc.2022.07.015
Autor:
David A. Wink, Robert H. Wiltrout, Giorgio Trinchieri, James B. Mitchell, Howard A. Young, David D. Roberts, Aparna H. Kesarwala, Angela Thetford, Anastasia L. Sowers, William DeGraff, C. Andrew Stewart, Julie L. Heinecke, Debashree Basudhar, David R. Soto-Pantoja, Sukhbir Kaur, Jonathan M. Weiss, Robert Y.S. Cheng, Lisa A. Ridnour
Supplementary Table 1. Th1 vs. Th2 Cytokine Trend. Supplementary Table 2. Effect of L-NAME on Radiation-induced Cytokine Expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524788bc8eff323eab7b75740197301a
https://doi.org/10.1158/0008-5472.22406027.v1
https://doi.org/10.1158/0008-5472.22406027.v1
Autor:
Yang Lei, Zhen Tian, Tonghe Wang, Justin Roper, Huiqiao Xie, Aparna H. Kesarwala, Kristin Higgins, Jeffrey D. Bradley, Tian Liu, Xiaofeng Yang
Publikováno v:
Medical Physics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::813979ede290024ff0a0bd7eaf1ad016
https://doi.org/10.1002/mp.16377
https://doi.org/10.1002/mp.16377