Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Aparna Gorthi"'
Autor:
Matthew E. Randolph, Marwa Afifi, Aparna Gorthi, Rachel Weil, Breelyn A. Wilky, Joshua Weinreb, Paul Ciero, Natalie ter Hoeve, Paul J. van Diest, Venu Raman, Alexander J.R. Bishop, David M. Loeb
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108925- (2024)
Summary: We previously demonstrated that RNA helicase DDX3X (DDX3) can be a therapeutic target in Ewing sarcoma (EWS), but its role in EWS biology remains unclear. The present work demonstrates that DDX3 plays a unique role in DNA damage repair (DDR)
Externí odkaz:
https://doaj.org/article/feee3811ebda42bda24ca7644f0ec5fe
Autor:
Steven W. Criscione, Matthew J. Martin, Derek B. Oien, Aparna Gorthi, Ricardo J. Miragaia, Jingwen Zhang, Huawei Chen, Daniel L. Karl, Kerrin Mendler, Aleksandra Markovets, Sladjana Gagrica, Oona Delpuech, Jonathan R. Dry, Michael Grondine, Maureen M. Hattersley, Jelena Urosevic, Nicolas Floc’h, Lisa Drew, Yi Yao, Paul D. Smith
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-13 (2022)
Abstract Third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs), including osimertinib, an irreversible EGFR-TKI, are important treatments for non-small cell lung cancer with EGFR-TKI sensitizing or EGFR T790M resistance mutations. While patien
Externí odkaz:
https://doaj.org/article/d7852854a3ba43459578c3fb424140e2
Autor:
Yu-Chiao Chiu, Hung-I Harry Chen, Tinghe Zhang, Songyao Zhang, Aparna Gorthi, Li-Ju Wang, Yufei Huang, Yidong Chen
Publikováno v:
BMC Medical Genomics, Vol 12, Iss S1, Pp 143-155 (2019)
Abstract Background The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insights into the oncogenic features modulating drug response. A recent study screened for the response of a thousand human
Externí odkaz:
https://doaj.org/article/431965f3a55c42008775e01409ca85e1
Autor:
Henry E. Miller, Aparna Gorthi, Nicklas Bassani, Liesl A. Lawrence, Brian S. Iskra, Alexander J. R. Bishop
Publikováno v:
Cancers, Vol 12, Iss 4, p 948 (2020)
Ewing sarcoma is an aggressive pediatric cancer of enigmatic cellular origins typically resulting from a single translocation event t (11; 22) (q24; q12). The resulting fusion gene, EWSR1-FLI1, is toxic or unstable in most primary tissues. Consequent
Externí odkaz:
https://doaj.org/article/4f8985b546884b24b496935f57ab64cf
Autor:
Aparna Gorthi, Alexander J. R. Bishop
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
Externí odkaz:
https://doaj.org/article/efa58b22390640ec85b09a764f255502
Autor:
Yu-Chiao Chiu, Hung-I Harry Chen, Tinghe Zhang, Songyao Zhang, Aparna Gorthi, Li-Ju Wang, Yufei Huang, Yidong Chen
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-1 (2019)
Following publication of the original article [1], the authors provided an updated funding statement to the article. The updated statement is as follows:
Externí odkaz:
https://doaj.org/article/06db076439754cb4bb748897f7775fd7
Autor:
Adam D Brown, Brian W Sager, Aparna Gorthi, Sonal S Tonapi, Eric J Brown, Alexander J R Bishop
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91222 (2014)
DNA replication fork stalling or collapse that arises from endogenous damage poses a serious threat to genome stability, but cells invoke an intricate signaling cascade referred to as the DNA damage response (DDR) to prevent such damage. The gene pro
Externí odkaz:
https://doaj.org/article/8b467f06cfef4ff69970e31aa3123155
Autor:
Alexander J.R. Bishop, Yidong Chen, José C.F. Moreira, Rosângela Mayer Gonçalves, Xavier Bernard, Aparna Gorthi, Sonal S. Tonapi, Eva Loranc, V. Pragathi Masamsetti, Alfeu Zanotto-Filho
Descriptive panel of hot-spot mutations in NFE2L2 and KEAP1 genes across lung and head and neck carcinoma samples available in the TCGA database (Provisional datasets) as obtained from the "Mutations" tool available in the TCGA cBioportal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136aabe2c760bfae4a4789aa38c4e1b7
https://doi.org/10.1158/1535-7163.22508418.v1
https://doi.org/10.1158/1535-7163.22508418.v1
Autor:
Alexander J.R. Bishop, Yidong Chen, José C.F. Moreira, Rosângela Mayer Gonçalves, Xavier Bernard, Aparna Gorthi, Sonal S. Tonapi, Eva Loranc, V. Pragathi Masamsetti, Alfeu Zanotto-Filho
Supplementary figure legends for figures S1 to S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdae1ffdfa8269c7fd669ece0fe5a483
https://doi.org/10.1158/1535-7163.22508415
https://doi.org/10.1158/1535-7163.22508415
Autor:
Manjeet K. Rao, Jack L. Arbiser, Alexander J. Bishop, Yidong Chen, Ratna K. Vadlamudi, Martha A. Hanes, Dmitri Ivanov, Dmytro Kovalskyy, Benjamin Onyeagucha, Santosh Timilsina, Aparna Gorthi, Subbarayalu Panneerdoss, Subapriya Rajamanickam
Supplementary Fig. 1. IB inhibits the growth of breast cancer cells in a dose and time dependent manner. Supplementary Fig. 2. IB inhibits migration and invasion of breast cancer cells. Supplementary Fig. 3. IB treatment inhibits in vivo growth and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2725a96b211db403a5ae9b651db57f2d
https://doi.org/10.1158/1078-0432.22457699
https://doi.org/10.1158/1078-0432.22457699