Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression

Autor: Sirkis, Daniel W, Bonham, Luke W, Aparicio, Renan E, Geier, Ethan G, Ramos, Eliana Marisa, Wang, Qing, Karydas, Anna, Miller, Zachary A, Miller, Bruce L, Coppola, Giovanni, Yokoyama, Jennifer S

Publikováno v: Sirkis, DW; Bonham, LW; Aparicio, RE; Geier, EG; Ramos, EM; Wang, Q; et al.(2016). Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression. ACTA NEUROPATHOLOGICA COMMUNICATIONS, 4, 98. doi: 10.1186/s40478-016-0367-7. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9rk6d6m3
Acta neuropathologica communications, vol 4, iss 1

Rare variation in TREM2 has been associated with greater risk for Alzheimer's disease (AD). TREM2 encodes a cell surface receptor expressed on microglia and related cells, and the R47H variant associated with AD appears to affect the ability of TREM2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f5a2c53af46543fd61a07396432b2fe8
http://www.escholarship.org/uc/item/9rk6d6m3

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BIOCHEMICAL ANALYSIS OF TREM2 DISEASE MUTATIONS

Autor: Sirkis, Daniel W., Aparicio, Renan E., Schekman, Randy

Publikováno v: In Alzheimer's & Dementia: The Journal of the Alzheimer's Association July 2016 12(7) Supplement:P1149-P1150