Application of Liquid Chromatography combined with Mass-Spectrometry (LC-MS) to establish identity and purity of PET-radiopharmaceuticals

Autor: J. Medema, Cm Jeronismusshalingh, Ejf Franssen, Gert Luurtsema, Gm Visser, Ap Bruins, Willem Vaalburg

Publikováno v: Applied Radiation and Isotopes. 45:937-940

This article describes the application of liquid chromatography combined with mass-spectrometry (LC-MS) as a new quality control tool for PET-radiopharmaceuticals. The final step in the production of 2-[ 18 F]fluoro-2-deoxy- d -glucose ( 18 F-FDG) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d608f093f637b9b818dc3b1725c6e150
https://doi.org/10.1016/0969-8043(94)90231-3

LOW-MOLECULAR-WEIGHT PROTEINS AS CARRIERS FOR RENAL DRUG TARGETING - PREPARATION OF DRUG PROTEIN CONJUGATES AND DRUG SPACER DERIVATIVES AND THEIR CATABOLISM IN RENAL-CORTEX HOMOGENATES AND LYSOSOMAL LYSATES

Autor: EJF FRANSSEN, Koiter, J., CAM KUIPERS, AP BRUINS, Moolenaar, F., Dick de Zeeuw, WH KRUIZINGA, RM KELLOGG, Dirk Meijer

Publikováno v: Journal of Medicinal Chemistry, 35(7), 1246-1259. AMER CHEMICAL SOC
University of Groningen

Low molecular weight proteins (LMWPs) are known to be reabsorbed and catabolized primarily by the proximal tubular cells of the kidneys. As such, LMWPs might serve as drug carriers that release drugs site-specifically in the kidney. We tested this co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0870e57fd1731627ef095a0d09d58521
https://research.rug.nl/en/publications/3d2dde0c-ed1b-449d-b07e-ea062b7f8e40

Isolation of 3,4-dihydroxyphenylacetic acid produced from p-hydroxyphenylacetic acid by immobilized plant cells of Mucuna pruriens and its identification by liquid chromatography/mass spectrometry

Autor: Niesko Pras, Ap Bruins

Publikováno v: Analytica Chimica Acta, 163(SEP), 91-100. ELSEVIER SCIENCE BV

A cell suspension culture originating from a Mucuna pruriens (L.) DC f. utilis (Wall ex Wight) Back cultivar was immobilized in calcium alginate. Biotransformation of p- hydroxyphenylacetic acid to 3,4-dihydroxyphenylacetic acid was done in a bubble-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abccec96b8ffb7198d0b56b28aa8de4
https://hdl.handle.net/11370/7d535c64-3f00-4d49-a3d0-d5c03056b624

Are clusters important in understanding the mechanisms in atmospheric pressure ionization? Part 1: Reagent ion generation and chemical control of ion populations.

Autor: Klee S; Institute for Pure and Applied Mass Spectrometry, Physical and Theoretical Chemistry, University of Wuppertal, 42119, Wuppertal, Germany, s.klee@uni-wuppertal.de., Derpmann V, Wißdorf W, Klopotowski S, Kersten H, Brockmann KJ, Benter T, Albrecht S, Bruins AP, Dousty F, Kauppila TJ, Kostiainen R, O'Brien R, Robb DB, Syage JA

Publikováno v: Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2014 Aug; Vol. 25 (8), pp. 1310-21. Date of Electronic Publication: 2014 May 22.

Chemical labeling of electrochemically cleaved peptides.

Autor: Roeser J; Analytical Biochemistry and Mass Spectrometry Core Facility, Department of Pharmacy, University of Groningen, Groningen, The Netherlands., Alting NF, Permentier HP, Bruins AP, Bischoff RP

Publikováno v: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2013 Feb 28; Vol. 27 (4), pp. 546-52.