Utility-based optimization of phase II / phase III clinical development

Autor: Aouni, Jihane

Le développement majeur de la thèse a été consacré au problème d’optimisation du choix de dose dans les essais de recherche de dose, en phase II. Nous avons considéré ce problème sous l’angle des fonctions d’utilité. Nous avons allou�

Externí odkaz: http://www.theses.fr/2019MONTS032/document

Design optimization for dose-finding trials: a review.

Autor: Aouni, Jihane^1,2 (AUTHOR) jihane9@hotmail.com, Bacro, Jean Noel² (AUTHOR), Toulemonde, Gwladys^2,3 (AUTHOR), Colin, Pierre¹ (AUTHOR), Darchy, Loic¹ (AUTHOR), Sebastien, Bernard¹ (AUTHOR)

Publikováno v: Journal of Biopharmaceutical Statistics. 2020, Vol. 30 Issue 4, p662-673. 12p. 1 Chart.

On the use of utility functions for optimizing phase II/phase III seamless trial designs

Autor: Aouni, Jihane, Bacro, Jean, Toulemonde, Gwladys, Colin, Pierre, Darchy, Loic, Sébastien, Bernard

Publikováno v: Journal of clinical trials
Journal of clinical trials, 2021, 10 (415), ⟨10.35248/2167-0870.20.10.415⟩
Journal of clinical trials, longdom publishing, 2021, 10 (415), ⟨10.35248/2167-0870.20.10.415⟩

International audience; Background: For several years adaptive designs became more and more popular in the pharmaceutical industry and in particular much attention was brought on adaptive seamless designs. Those designs combine the phase II dose find

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6ddf8c280825ebc5a610efec4891c6c8
https://inria.hal.science/hal-02491531/file/Aouni_etal_sub1_2019.pdf

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Utility-Based Dose-Finding in Practice: Some Empirical Contributions and Recommendations

Autor: Aouni, Jihane, Bacro, Jean-Nöel, Toulemonde, Gwladys, Sébastien, Bernard

Publikováno v: Annals of Biostatistics & Biometric Applications
Annals of Biostatistics & Biometric Applications, Iris Publishers, LLC, 2019, 3 (3), ⟨10.33552/ABBA.2019.03.000552⟩
Annals of Biostatistics & Biometric Applications, 2019, 3 (3), ⟨10.33552/ABBA.2019.03.000552⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72db7c184c6a13edf76c72fec09823d6
https://hal.inria.fr/hal-03500437