Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Aoli Xiong"'
Autor:
Aoli Xiong, Simran Kaushal, Ian Junjie Tay, Bevin P. Engelward, Jongyoon Han, Peter R. Preiser
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100797- (2021)
Summary: Comet assay is a standard approach for studying DNA damage in malaria, but high-throughput options are not available. The CometChip was previously developed using mammalian cells as a high-throughput version of the comet assay. It is based o
Externí odkaz:
https://doaj.org/article/0a6b0d38982740a2bba334d1bd35f6eb
Autor:
Aoli Xiong, Prem Prakash, Xiaohong Gao, Marvin Chew, Ian Jun Jie Tay, Charles J. Woodrow, Bevin P. Engelward, Jongyoon Han, Peter R. Preiser
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107996- (2020)
Summary: Southeast Asia has been the hotbed for the development of drug-resistant malaria parasites, including those with resistance to artemisinin combination therapy. While mutations in the kelch propeller domain (K13 mutations) are associated with
Externí odkaz:
https://doaj.org/article/23a3e6e5cd1d4f26a0513b7038e8eb83
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Upon Plasmodium falciparum infection of the red blood cells (RBCs), the parasite replicates and consumes haemoglobin resulting in the release of free heme which is rapidly converted to hemozoin crystallites. The bulk magnetic susceptibility of infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c292c53f9b36389b23a30531e48cc0c0
http://link.springer.com/article/10.1038/s41598-019-38805-2
http://link.springer.com/article/10.1038/s41598-019-38805-2
Autor:
Jongyoon Han, Prem Prakash, Bevin P. Engelward, Xiaohong Gao, Ian Jun Jie Tay, Charles J. Woodrow, Peter R. Preiser, Marvin Chew, Aoli Xiong
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107996-(2020)
Cell Reports
Cell Reports
Summary Southeast Asia has been the hotbed for the development of drug-resistant malaria parasites, including those with resistance to artemisinin combination therapy. While mutations in the kelch propeller domain (K13 mutations) are associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8583dc3d4e140ea11bd2364041661b12
http://www.sciencedirect.com/science/article/pii/S2211124720309815
http://www.sciencedirect.com/science/article/pii/S2211124720309815
Autor:
Rajesh Chandramohanadas, Gowtham Subramanian, Meenakshi A. Belekar, Alok Tanala Patra, Tejashri Hingamire, Peter R. Preiser, Zbynek Bozdech, Dhanasekaran Shanmugam, Aoli Xiong
Publikováno v:
Antimicrobial agents and chemotherapy, vol 64, iss 5
We report a systematic, cellular phenotype-based antimalarial screening of the Medicines for Malaria Venture Pathogen Box collection, which facilitated the identification of specific blockers of late-stage intraerythrocytic development of Plasmodium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6a0ea45f56fb368158470f345931a2
https://doi.org/10.1128/aac.01802-19
https://doi.org/10.1128/aac.01802-19
Autor:
Aoli Xiong, Alok Tanala Patra, Peter R. Preiser, Tejashri Hingamire, Zbynek Bozdech, Meenakshi A. Belekar, Dhanasekaran Shanmugam, Gowtham Subramanian, Rajesh Chandramohanadas
We report a systematic, cellular phenotype-based antimalarial screening of the MMV Pathogen Box collection, which facilitated the identification of specific blockers of late stage intraerythrocytic Plasmodium falciparum maturation. First, from standa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f888c951f9401b864d05096eb2e297a9
https://doi.org/10.1101/772434
https://doi.org/10.1101/772434
Autor:
Aoli Xiong
Artemisinin-based combination therapies (ACT), the first-line anti-malarial treatments recommended by World Health Organization (WHO), have achieved great success globally since their introduction. However, emerging artemisinin resistance in Southeas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91ce2011fa52fc994684f2dff453ae1
https://doi.org/10.32657/10220/49591
https://doi.org/10.32657/10220/49591
Autor:
Alok Tanala, Patra, Tejashri, Hingamire, Meenakshi A, Belekar, Aoli, Xiong, Gowtham, Subramanian, Zbynek, Bozdech, Peter, Preiser, Dhanasekaran, Shanmugam, Rajesh, Chandramohanadas
Publikováno v:
Antimicrob Agents Chemother
We report a systematic, cellular phenotype-based antimalarial screening of the Medicines for Malaria Venture Pathogen Box collection, which facilitated the identification of specific blockers of late-stage intraerythrocytic development of Plasmodium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ff35fb5e79c05fb9b0f99f29235a8e6
https://pubmed.ncbi.nlm.nih.gov/32071059
https://pubmed.ncbi.nlm.nih.gov/32071059
Publikováno v:
IEEE Journal of Selected Topics in Quantum Electronics. 22:179-187
Malaria is a global disease that desires early diagnosis in the field, for which one way is to detect hemozoin (a unique biomarker of malaria infection) at low concentrations. Moreover, many anti-malarial drugs inhibit the formation of hemozoin and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7da411d5e04f041e2ea7fd77fcdc8fb
https://doi.org/10.1109/jstqe.2016.2518959
https://doi.org/10.1109/jstqe.2016.2518959
Autor:
Leona D. Samson, John Winters, Carol D. Swartz, Aoli Xiong, Norah A. Owiti, Jongyoon Han, Jing Ge, Le P. Ngo, Yang Su, Leslie Recio, Bevin P. Engelward
Publikováno v:
Nucleic Acids Research
Genotoxicity testing is critical for predicting adverse effects of pharmaceutical, industrial, and environmental chemicals. The alkaline comet assay is an established method for detecting DNA strand breaks, however, the assay does not detect potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724ad2eda4b52af72cb481769e39dc06
http://europepmc.org/articles/PMC7026589
http://europepmc.org/articles/PMC7026589