Výsledky vyhledávání - "Aojula, Harmesh S"

N-tert-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00691d

Autor: Offerman, Shaun C., Kadirvel, Manikandan, Abusara, Osama H., Bryant, Jennifer L., Telfer, Brian A., Brown, Gavin, Freeman, Sally, White, Anne, Williams, Kaye J., Aojula, Harmesh S.

Publikováno v: MedChemComm

Prenylated sequences unlocks the development of new therapeutics as demonstrated for an anticancer agent.
Natural prenylated indoles have been proposed as potential anticancer agents. To exploit this discovery for developing new peptide therapeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::895e59b35565f92fd7f628deda352ee0
http://europepmc.org/articles/PMC6072501

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Sequence-Specific Detection of Unlabeled Nucleic Acid Biomarkers Using a 'One-Pot' 3D Molecular Sensor

Autor: Yousaf, Sameen, King, Patrick J. S., Miller, Aline F., Saiani, Alberto, Clarke, David J., Trivoluzzi, Linda T., Aojula, Harmesh S., Bichenkova, Elena V.

Publikováno v: Yousaf, S, King, P J S, Miller, A F, Saiani, A, Clarke, D J, Trivoluzzi, L T, Aojula, H S & Bichenkova, E V 2019, ' Sequence-Specific Detection of Unlabeled Nucleic Acid Biomarkers Using a “One-Pot” 3D Molecular Sensor ', Analytical Chemistry, vol. 91, no. 15, pp. 10016–10025 . https://doi.org/10.1021/acs.analchem.9b01841

DNA and RNA biomarkers have not progressed beyond the automated specialized clinic due to failure in the reproducibility necessary to standardize robust and rapid nucleic acid detection at the point of care, where health outcomes can be most improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::6c0ecbf453b72c07245e32ecea7d8c12
https://research.manchester.ac.uk/en/publications/a1ef826f-6cd4-4d11-8370-fa1bbcdad042