Výsledky vyhledávání - "Aoife Quinlan"

PEGylated cyclodextrins as novel siRNA nanosystems: Correlations between polyethylene glycol length and nanoparticle stability

Autor: Bruno M.D.C. Godinho, Julien Ogier, Caitriona M. O'Driscoll, Aoife Quinlan, Raphael Darcy, Brendan T. Griffin, John F. Cryan

Publikováno v: International Journal of Pharmaceutics. 473:105-112

Silencing disease-related genes in the central nervous system (CNS) using short interfering RNA (siRNA) holds great promise for treating neurological disorders. Yet, delivery of RNAi therapeutics to the brain poses major challenges to non-viral syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40b1deaa95aedf16b97df03243a1146
https://doi.org/10.1016/j.ijpharm.2014.06.054

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In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery

Autor: Marc Devocelle, Caitriona M. O'Driscoll, Aoife Quinlan, Raphael Darcy, Stephane Desgranges, Aoife M. O'Mahony, Julien Ogier, John F. Cryan

Publikováno v: Pharmaceutical Research. 30:1086-1098

Purpose: Development of RNA interference based therapeutics for neurological and neurodegenerative diseases is hindered by a lack of non-viral vectors with suitable properties for systemic administration. Amphiphilic and cationic cyclodextrins (CD) o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d196c6bc19a073d3e9d1535db2e304aa
https://doi.org/10.1007/s11095-012-0945-8

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The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium

Autor: Lindsay J. Hall, Silvia Melgar, Fergus Shanahan, John MacSharry, Kenneth Nally, Aoife Quinlan, Grainne Hurley, Carola T. Murphy

Publikováno v: Infection and Immunity. 80:2712-2723

The sphingosine-1-phosphate (S1P) analogue FTY720 is therapeutically efficacious in multiple sclerosis and in the prevention of transplant rejection. It prevents the migration of lymphocytes to sites of pathology by trapping them within the periphera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b48fcfa584d1a6322093851449f0abb
https://doi.org/10.1128/iai.06319-11

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Technical Advance: Function and efficacy of an α4-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis

Autor: Aoife Quinlan, John MacSharry, Peter G. McLean, Andrea C. Haynes, Gerard M. Moloney, Kenneth Nally, Fergus Shanahan, Kevin Lee, Silvia Melgar, Carola T. Murphy, Emilie Faivre, Liam O'Mahony

Publikováno v: Journal of Leukocyte Biology. 88:1271-1278

Method for in vivo bioluminescence imaging as a valuable strategy for pre-clinical evaluation of leukocyte trafficking as shown here for small molecule α4-integrin antagonists as a promising therapeutic for IBD. Leukocyte trafficking is a therapeuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb20cc2e932d2b9f78a72689b6d9b26
https://doi.org/10.1189/jlb.0909627

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Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for rna interference in the central nervous system

Autor: Bruno M.D.C. Godinho, John F. Cryan, Aoife Quinlan, Cristina Torres-Fuentes, Julien Ogier, Raphael Darcy, Joanna McCarthy, David J. McCarthy, Caitriona M. O'Driscoll, Caroll J. Beltrán

Publikováno v: BIOMATERIALS
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Progression of RNA interference-based gene silencing technologies for the treatment of disorders of the central nervous system (CNS) depends on the availability of efficient non-toxic nanocarriers. Despite advances in the field of nanotechnology unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c23e48d474b1e8188b4df4e44336d8e

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Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

Autor: Ruaidhri Jackson, Shuo Yang, Fergus Shanahan, Aoife Quinlan, Barry Hall, Gabriella Aviello, Padraic G. Fallon, Silvia Melgar, Ronan Bergin, Fiachra Humphries, Marc E. Healy, Paul N. Moynagh, Bingwei Wang, Deirdre McNamara, Trevor Darby

Publikováno v: Nature immunology. 14(9)

Mutations that result in loss of function of Nod2, an intracellular receptor for bacterial peptidoglycan, are associated with Crohn’s disease. Here we found that the E3 ubiquitin ligase Pellino3 was an important mediator in the Nod2 signaling pathw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78710e83133c107d4e99c23b4673e51b
https://pubmed.ncbi.nlm.nih.gov/23892723

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Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kBp50

Autor: Finbarr O'Sullivan, Mary Canavan, Trevor Darby, Paul N. Moynagh, Aoife Quinlan, Jennifer K. Dowling, John MacSharry, Laura E. Collins, Hiroyuki Kagechika, Silvia Melgar, Ciara McCarthy, Nadia Ben Larbi, Grainne Hurley, Carola T. Murphy, Gerry Moloney, Christine E. Loscher

Publikováno v: Canavan, M, McCarthy, C, Larbi, N B, Dowling, J K, Collins, L, O'Sullivan, F, Hurley, G, Murphy, C, Quinlan, A, Moloney, G, Darby, T, MacSharry, J, Kagechika, H, Moynagh, P, Melgar, S & Loscher, C E 2014, ' Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-κBp50 ', Innate Immunity, vol. 20, no. 7, pp. 675-87 . https://doi.org/10.1177/1753425913501915

There is now convincing evidence that liver X receptor (LXR) is an important modulator of the inflammatory response; however, its mechanism of action remains unclear. This study aimed to examine the effect of LXR on the IL-12 family of cytokines and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288c63fe11801a81f03900a69f996489

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Natural killer cells protect against mucosal and systemic infection with the enteric pathogen Citrobacter rodentium

Autor: Silvia Melgar, Fergus Shanahan, Aoife Quinlan, Kenneth Nally, Lindsay J. Hall, Carola T. Murphy, Grainne Hurley

Publikováno v: Infection and immunity. 81(2)

Natural killer (NK) cells are traditionally considered in the context of tumor surveillance and viral defense, but their role in bacterial infections, particularly those caused by enteric pathogens, is less clear. C57BL/6 mice were orally gavaged wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dacb7ec59039ae4721e19a08cb430b8
https://pubmed.ncbi.nlm.nih.gov/23208605

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Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system

Autor: Grainne Hurley, Aoife Quinlan, Joanna McCarthy, Ludovic Bourre, David P. Walsh, Silvia Melgar, Julien Ogier, Caitriona M. O'Driscoll, Raphael Darcy, Fergus Shanahan, Martin J. O’Neill

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 168(1)

Inflammatory bowel disease (IBD) is a chronic relapsing inflammation of the gastrointestinal tract. The cytokine TNF-alpha (TNF-α) plays a pivotal role in mediating this inflammatory response. RNA interference (RNAi) holds great promise for the spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d1af8d5ee793052318a14ee43a5669
https://pubmed.ncbi.nlm.nih.gov/23500058

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Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis

Autor: Aoife Quinlan, Lindsay J. Hall, Pat G. Casey, Silvia Melgar, Emilie Faivre, Fergus Shanahan, Carola T. Murphy, Gerard M. Moloney, Kenneth Nally

Summary Inflammatory bowel disease (IBD) is associated with neutrophil infiltration into the mucosa and crypt abscesses. The chemokine interleukin (IL)-8 [murine homologues (KC) and macrophage inflammatory protein (MIP)-2] and its receptor CXCR2 are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7a257b36b97c6df11e6a9dbbf2632c
https://hdl.handle.net/10468/640

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