Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Aoife M. Devery"'
Autor:
Rekha Wadekar, Yanyan Jiang, Anderson J. Ryan, Anika M. Weber, Aoife M. Devery, Sivan M. Bokobza
Publikováno v:
International Journal of Oncology
Vascular endothelial growth factor (VEGF) is a key stimulator of physiological and pathological angiogenesis. VEGF signals primarily through VEGF receptor 2 (VEGFR2), a receptor tyrosine kinase whose expression is found predominantly on endothelial c
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 88:947-954
Purpose To evaluate the combination of radiation and an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in preclinical models of human non-small cell lung cancer. Methods and Materials Sensitivity to an EGFR TKI (gefitinib) or
Publikováno v:
Oncotarget
Although non-small cell lung cancer (NSCLC) patients with EGFR mutation positive (EGFR M+) tumors initially respond well to EGFR tyrosine kinase inhibitor (TKI) monotherapy, the responses are usually incomplete. In this study we show that AKT inhibit
Autor:
Ornella Belvedere, Caroline Conway, Pamela Rabbitts, Lucy F. Stead, Kostas Papagiannopoulos, Henry M. Wood, Philip Egan, Catherine Daly, Stefano Berri, Aoife M. Devery, Anderson J. Ryan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 11, p e78823 (2013)
PLoS ONE, Vol 8, Iss 11, p e78823 (2013)
Squamous cell carcinoma (SCC) of the lung kills over 350,000 people annually worldwide, and is the main lung cancer histotype with no targeted treatments. High-coverage whole-genome sequencing of the other main subtypes, small-cell and adenocarcinoma
Autor:
Luiza Madia Lourenco, Fiona Cahill, Sivan M. Bokobza, Yanyan Jiang, Anika M. Weber, Nuramalina H. Mumin, Thomas M. Ashton, Aoife M. Devery, Anderson J. Ryan, Neele Drobnitzky
Publikováno v:
Molecular Cancer Therapeutics. 14:C114-C114
Lung cancer is the leading cause of cancer related death worldwide and adenocarcinoma is the most prevalent subtype. LKB1 (STK11) is the second most commonly altered tumour suppressor in adenocarcinoma and is inactivated in 17% of samples (1). LKB1 i
Autor:
Sivan M. Bokobza, Aoife M. Devery, Yanyan Jiang, Anika M. Weber, Tom Verbiest, Anderson J. Ryan
Publikováno v:
Cancer Research. 74:3785-3785
Purpose: Poly (ADP-ribose) polymerase (PARP) detects DNA single strand breaks and facilitates their repair. Recently, PARP inhibitors have been shown to potentiate radiotherapy in mouse models of human non-small-cell lung cancer (NSCLC) by compromisi
Publikováno v:
European Journal of Cancer. 50:S121
Publikováno v:
European Journal of Cancer. 50:S227
Publikováno v:
Molecular Cancer Therapeutics. 12:B91-B91
Introduction: Cancer cells frequently exhibit defects in components of the DNA-damage response (DDR) and may as a consequence become highly dependent on remaining DDR pathways to survive DNA damage. Targeting such remaining DDR pathways to confer syn
Autor:
Anika M. Weber, Sivan M. Bokobza, Yanyan Jiang, Anderson J. Ryan, Rekha Wadeka, Aoife M. Devery
Publikováno v:
Cancer Research. 73:5254-5254
Background: Vascular endothelial growth factor (VEGF) is a key stimulator of physiological and pathological angiogenesis. VEGF signals primarily through VEGF receptor 2 (VEGFR2), a receptor tyrosine kinase whose expression is generally considered to