Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aoibhinn McDonnell"'
Autor:
Charlie W. Lees, Joana Torres, Yvette Leung, Séverine Vermeire, Marc Fellmann, Irene Modesto, Aoibhinn McDonnell, Krisztina Lazin, Michael Keating, Martina Goetsch, Joseph Wu, Edward V. Loftus
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 17 (2024)
Background: Etrasimod is an oral, once-daily (QD), selective sphingosine 1-phosphate (S1P) 1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). It is known that non-serious treatment-emergent adverse ev
Externí odkaz:
https://doaj.org/article/bd61ea0a00f144c2bda7fa6aa6b05c68
Autor:
Pieter Siebenga, Guido vanAmerongen, Justin L. Hay, Aoibhinn McDonnell, Donal Gorman, Richard Butt, Geert Jan Groeneveld
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 318-324 (2020)
Sodium channel blockers are used for the treatment of pain, but this is limited by the lack of selectivity for different sodium channel subtypes, which can result in central nervous system and cardiovascular side effects. As such, there is special in
Externí odkaz:
https://doaj.org/article/00db826e397843549f2242867246cc5a
Autor:
Geert Jan Groeneveld, Guido van Amerongen, Pieter S. Siebenga, Richard P. Butt, Justin L. Hay, Aoibhinn McDonnell, Donal Gorman
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 318-324 (2020)
Clinical and Translational Science
Clinical and Translational Science
Sodium channel blockers are used for the treatment of pain, but this is limited by the lack of selectivity for different sodium channel subtypes, which can result in central nervous system and cardiovascular side effects. As such, there is special in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27398e43859e792191b0fe0cdc7418db
https://doaj.org/article/00db826e397843549f2242867246cc5a
https://doaj.org/article/00db826e397843549f2242867246cc5a
Autor:
Laura Iavarone, Raulin Surujbally, Simon Kirby, Zahid Ali, Richard P. Butt, Aoibhinn McDonnell, Susie Collins
Publikováno v:
Pain. 159(8)
The effect of PF-05089771, a selective, peripherally restricted Nav1.7 sodium channel blocker on pain due to diabetic peripheral neuropathy was investigated in a randomised, placebo and active-controlled parallel group clinical trial (NCT02215252). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c0f1b5b78b7ee0f98fa19fe7928b72
https://pubmed.ncbi.nlm.nih.gov/29578944
https://pubmed.ncbi.nlm.nih.gov/29578944
Autor:
Adam R. Brown, Aoibhinn McDonnell, Lishuang Cao, Paul Whiting, Malgorzata A. Mis, Alexandre J.C. Loucif, Aristos J. Alexandrou, Pierre-Philippe Saintot, Edward B. Stevens, Zahid Ali, James Bilsland, Stephen G. Waxman, Andrew D. Randall, Simon Kirby, Ruth M. McKernan, Richard P. Butt, Phil Stanley, Alex Gutteridge, Anja Nitzsche, Sanela Tarabar, Gareth T. Young
Publikováno v:
Science translational medicine. 8(335)
In common with other chronic pain conditions, there is an unmet clinical need in the treatment of inherited erythromelalgia (IEM). TheSCN9Agene encoding the sodium channel Nav1.7 expressed in the peripheral nervous system plays a critical role in IEM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af51cd5dc1b3771cfbcafe795b3b9207
https://pubmed.ncbi.nlm.nih.gov/27099175
https://pubmed.ncbi.nlm.nih.gov/27099175
Autor:
Jan Vollert, Aoibhinn McDonnell, Sulayman D. Dib-Hajj, Fiona Brock, Sonia Cobain, Zahid Ali, Sanela Tarabar, Stephen G. Waxman, Tina Mainka, Betsy R. Schulman
Publikováno v:
Brain : a journal of neurology. 139(Pt 4)
Inherited erythromelalgia, the first human pain syndrome linked to voltage-gated sodium channels, is widely regarded as a genetic model of human pain. Because inherited erythromelalgia was linked to gain-of-function changes of sodium channel Nav1.7 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d081afb45c06d67d6f66517cb4b65a1f
https://pubmed.ncbi.nlm.nih.gov/26920677
https://pubmed.ncbi.nlm.nih.gov/26920677
Autor:
Alison Kerr, Hilary Cass, David J. Bunyan, Gun Peggy Knudsen, Veronica Mash, Hayley Archer, Jacqueline Perry, Sharon D. Whatley, Aoibhinn McDonnell, Mary T. Gardiner, Tony Charman, Sheena Reilly, Angus John Clarke, Karen Helene Ørstavik, Rebecca H. Mount, Mark E.S. Bailey, Richard P. Hastings, Maj Hultén, Kirstine Ravn, Tracey C. S. Neilson
Publikováno v:
European Journal of Human Genetics. 13:1121-1130
We aimed to improve the understanding of genotype-phenotype correlations in Rett syndrome (RS) by adopting a novel approach to categorising phenotypic dimensions - separating typicality of presentation, outcome severity and age of onset - and by clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dada6b9677205a93c1082f91fcf8b4d
https://doi.org/10.1038/sj.ejhg.5201471
https://doi.org/10.1038/sj.ejhg.5201471
Autor:
Aoibhinn McDonnell
Publikováno v:
Veterinary Record. 169:i-i
After qualifying, Aoibhinn McDonnell gained a Masters and a PhD. She has worked in research, small animal practice and industry. She now works in early stage drug development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::008b9c902ce7101dc3b4889fac63dc6c
https://doi.org/10.1136/vr.g7153
https://doi.org/10.1136/vr.g7153