Výsledky vyhledávání - "Aoi Wakabayashi"

Akademický článek

Direct Comparison of Mononucleated and Binucleated Cardiomyocytes Reveals Molecular Mechanisms Underlying Distinct Proliferative Competencies

Autor: Rebecca Windmueller, John P. Leach, Apoorva Babu, Su Zhou, Michael P. Morley, Aoi Wakabayashi, Nataliya B. Petrenko, Patrick Viatour, Edward E. Morrisey

Publikováno v: Cell Reports, Vol 30, Iss 9, Pp 3105-3116.e4 (2020)

Summary: The mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury. Several reports have demonstrated that mononucleated cardiomyocytes are more r

Externí odkaz: https://doaj.org/article/4cc9d514ae934b469d3b2fc8c7e2809f

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Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression

Autor: Aoi Wakabayashi, Maryanne Kihiu, Malini Sharma, A. Josephine Thrasher, Megan S. Saari, Mathieu Quesnel-Vallières, Osheiza Abdulmalik, Scott A. Peslak, Eugene Khandros, Cheryl A. Keller, Belinda M. Giardine, Yoseph Barash, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Publikováno v: Blood advances. 6(23)

The fetal-to-adult hemoglobin transition is clinically relevant because reactivation of fetal hemoglobin (HbF) significantly reduces morbidity and mortality associated with sickle cell disease (SCD) and β-thalassemia. Most studies on the development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28be025594677320dfead8f98b4f5ac6
https://pubmed.ncbi.nlm.nih.gov/35622975

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Direct Comparison of Mononucleated and Binucleated Cardiomyocytes Reveals Molecular Mechanisms Underlying Distinct Proliferative Competencies

Autor: John Leach, Michael Morley, Aoi Wakabayashi, Rebecca Windmueller, Apoorva Babu, Edward E. Morrisey, Nataliya B. Petrenko, Su Zhou, Patrick Viatour

Publikováno v: Cell Reports, Vol 30, Iss 9, Pp 3105-3116.e4 (2020)
Cell reports

SUMMARY The mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury. Several reports have demonstrated that mononucleated cardiomyocytes are more re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d668c09b8d8648e5daa9fb2f31cc674b
http://www.sciencedirect.com/science/article/pii/S2211124720301959

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ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency

Publikováno v: Molecular cell. 81(17)

Summary The transformed state in acute leukemia requires gene regulatory programs involving transcription factors and chromatin modulators. Here, we uncover an IRF8-MEF2D transcriptional circuit as an acute myeloid leukemia (AML)-biased dependency. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fc0852da74c6aa88d177038e2045f5
https://pubmed.ncbi.nlm.nih.gov/34478652

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Interrogating Post-Transcriptional Mechanisms of Fetal Hemoglobin Regulation

Autor: Mathieu Quesnel-Vallières, Belinda Giardine, Gerd A. Blobel, Malini Sharma, Scott A. Peslak, Ross C. Hardison, Junwei Shi, Osheiza Abdulmalik, Aoi Wakabayashi, Maryanne Kihiu, Cheryl A. Keller

Publikováno v: Blood. 138:3079-3079

Elevated levels of fetal hemoglobin (HbF) significantly ameliorate clinical outcomes for patients with beta-hemoglobinopathies, such as sickle cell disease (SCD). The only FDA-approved drug for treating SCD through inducing HbF is hydroxyurea, howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09a357b0105123762f3a234f09af151a
https://doi.org/10.1182/blood-2021-151488

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Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders

Autor: Vijay G. Sankaran, Leif S. Ludwig, Claudia Fiorini, Patrick McDonel, Makiko Yasuda, Aoi Wakabayashi, Avik Choudhuri, Jacob C. Ulirsch, Leonard I. Zon

Publikováno v: Proceedings of the National Academy of Sciences. 113:4434-4439

Whole-exome sequencing has been incredibly successful in identifying causal genetic variants and has revealed a number of novel genes associated with blood and other diseases. One limitation of this approach is that it overlooks mutations in noncodin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1c976ec61c6a169d8a2a85c8433b80
https://doi.org/10.1073/pnas.1521754113

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X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation

Autor: Leif S. Ludwig, Jacob C. Ulirsch, Rafael Bejar, R. Coleman Lindsley, Vijay G. Sankaran, Senkottuvelan Kadirvel, Vassili Tchaikovskii, Jiahai Shi, Aoi Wakabayashi, David P. Steensma, David F. Bishop, Scott B. Lovitch

Publikováno v: Journal of Clinical Investigation. 130:552-552

Macrocytic anemia with abnormal erythropoiesis is a common feature of megaloblastic anemias, congenital dyserythropoietic anemias, and myelodysplastic syndromes. Here, we characterized a family with multiple female individuals who have macrocytic ane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de185c8462e63f310581bb673e769784
https://doi.org/10.1172/jci132538

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Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis

Autor: Harvey F. Lodish, Mark D. Fleming, Jennifer C. Eng, Leif S. Ludwig, Jacob C. Ulirsch, Vijay G. Sankaran, Hyunjii Cho, Aoi Wakabayashi

Publikováno v: American Journal of Hematology. 90:386-391

Genome-wide association studies (GWAS) hold tremendous promise to improve our understanding of human biology. Recent GWAS have revealed over 75 loci associated with erythroid traits, including the 4q27 locus that is associated with red blood cell siz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e829c727988e57bacfaf18c12cafae4a
https://doi.org/10.1002/ajh.23952

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Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells

Publikováno v: Cell Stem Cell
Cell stem cell, vol 18, iss 1

Multipotent and pluripotent stem cells are potential sources for cell and tissue replacement therapies. For example, stem cell-derived red blood cells (RBCs) are a potential alternative to donated blood, but yield and quality remain a challenge. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b0e632797eccca20d30117c5137bd3

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